Injectable macroporous microparticles for soft tissue augmentation

Macroporous polymeric microparticles have been fabricated using a combination of particulate leaching and gas foaming techniques. Controlling the concentration of ammonium bicarbonate particles and the spin speed of the microemulsion in poly (ε-caprolactone) (PCL) yields a range of macroporous microparticles with interconnected pores (10-50μm) that may promote cell and tissue ingrowth in vivo when implanted subcutaneously. This fabrication technique introduces a novel template which can be modified to meet a diverse set of material and biological specifications.

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