The Value of Computed Tomography-Guided Percutaneous Lung Biopsy Combined With Rapid On-Site Evaluation in Diagnosis of Peripheral Pulmonary Nodules

Objective: To investigate the value of computed tomography-guided percutaneous lung biopsy (CT-PLB) combined with rapid on-site evaluation (ROSE) in the diagnosis of peripheral pulmonary lesions (PPLs). Methods: A total of 108 patients who diagnosed with PPLs by chest CT examination were prospectively collected and randomly divided into ROSE group (n = 56) and No-ROSE group (n = 52). Both groups received CT-PLB and pathological examination. The smear submitted for ROSE was stained using Diff Quik dye. The accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), number of punctures, puncture time and incidence of complications were compared between the two groups. Results: The accuracy, sensitivity, specificity, PPV, and NPV of the ROSE group were 89.29%, 87.50%, 91.67%, 93.33%, and 84.62%, respectively. The number of punctures in the ROSE group was significantly lower than that in the No-ROSE group (P < .05). The incidence of pneumothorax and hemoptysis in the ROSE group were lower than those in the No-ROSE group, but there was no statistical difference between the two groups (P > .05). ROSE has good concordance with routine pathological examination in the diagnosis of unidentified PPLs (Kappa = 0.786, P < .01). Conclusions: CT-PLB combined with ROSE is a safe and effective method for the diagnosis of PPLs.

[1]  Yan Wang,et al.  Improved diagnostic yield of transbronchial lung biopsy in peripheral pulmonary lesions using a combination of endobronchial ultrasound and rapid on-site evaluation , 2021, The Journal of international medical research.

[2]  Wei Liu,et al.  Diagnostic value of endobronchial ultrasound combined with rapid on‐site evaluation of transbronchial lung biopsy for peripheral pulmonary lesions , 2021, Diagnostic cytopathology.

[3]  À. Jaén,et al.  Concordance Between Rapid On-Site Evaluation and Final Cytologic Diagnosis in Patients Undergoing Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Non-Small Cell Lung Cancer Staging. , 2019, American journal of clinical pathology.

[4]  Siyu Sun,et al.  Rapid on-site evaluation (ROSE) with EUS-FNA: The ROSE looks beautiful , 2019, Endoscopic ultrasound.

[5]  N. Nayak,et al.  Role of Rapid On-site Evaluation in CT-guided Fine Needle Aspiration Cytology of Lung Nodules , 2018, Journal of cytology.

[6]  L. Layfield,et al.  Cost‐effectiveness of rapid on‐site evaluation of the adequacy of FNA cytology samples performed by nonpathologists , 2018, Cancer cytopathology.

[7]  L. Layfield,et al.  Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment , 2018, Acta Cytologica.

[8]  A. Aggarwal,et al.  Impact of Rapid On‐Site Cytological Evaluation (ROSE) on the Diagnostic Yield of Transbronchial Needle Aspiration During Mediastinal Lymph Node Sampling: Systematic Review and Meta‐Analysis , 2017, Chest.

[9]  M. Mino‐Kenudson,et al.  Rapid On-Site Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspirations for the Diagnosis of Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society. , 2017, Archives of pathology & laboratory medicine.

[10]  R. Wu,et al.  Cytology and histology: Complementary diagnostic modalities during endoscopic ultrasound-guided tissue acquisition , 2017 .

[11]  I. Porfyridis,et al.  Rapid on‐site evaluation with the Hemacolor rapid staining method of medical thoracoscopy biopsy specimens for the management of pleural disease , 2016, Respirology.

[12]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[13]  M. Bruno,et al.  Mapping international practice patterns in EUS-guided tissue sampling: outcome of a global survey , 2016, Endoscopy International Open.

[14]  F. Herth,et al.  The Solitary Pulmonary Nodule , 2015, Respiration.

[15]  Daniel P Steinfort,et al.  Diagnostic utility and accuracy of rapid on-site evaluation of bronchoscopic brushings , 2014, European Respiratory Journal.

[16]  S. Gasparini,et al.  The role of the pulmonologist in rapid on-site cytologic evaluation of transbronchial needle aspiration: a prospective study. , 2014, Chest.

[17]  K. Kiura,et al.  Rapid on-site evaluation with BIOEVALUATOR® during endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing pulmonary and mediastinal diseases , 2014, Annals of thoracic medicine.

[18]  M. Giovagnoli,et al.  Efficacy and cost effectiveness of rapid on site examination (ROSE) in management of patients with mediastinal lymphadenopathies. , 2013, European review for medical and pharmacological sciences.

[19]  M. Fassan,et al.  Role and accuracy of rapid on‐site evaluation of CT‐guided fine needle aspiration cytology of lung nodules , 2011, Cytopathology : official journal of the British Society for Clinical Cytology.

[20]  S. Mukherjee,et al.  Computed tomography-guided fine needle aspiration cytology of solitary pulmonary nodules suspected to be bronchogenic carcinoma: Experience of a general hospital , 2010, Journal of cytology.

[21]  P. Mitra,et al.  CT guided fine needle aspiration cytology of thoracic mass lesions: a prospective study of immediate cytological evaluation. , 2007, Indian journal of pathology & microbiology.