Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening.

[1]  M. Donia,et al.  Peptide Super-Agonist Enhances T-Cell Responses to Melanoma , 2019, Front. Immunol..

[2]  D. Speiser,et al.  T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus , 2017, European journal of immunology.

[3]  Cory M. Ayres,et al.  Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings , 2017, Front. Immunol..

[4]  D. Speiser,et al.  TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency. , 2017, JCI insight.

[5]  A. Sewell,et al.  Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy. , 2017, Bio-protocol.

[6]  A. Sewell,et al.  Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens , 2017, Journal of visualized experiments : JoVE.

[7]  Ben M. Webb,et al.  Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in bioinformatics.

[8]  Berk Hess,et al.  GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .

[9]  D. Speiser,et al.  Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence , 2015, The Journal of Immunology.

[10]  F. Wong,et al.  Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide* , 2015, The Journal of Biological Chemistry.

[11]  J. E. Brewer,et al.  T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells , 2015, Clinical and experimental immunology.

[12]  M. Delorenzi,et al.  Long-lasting stem cell–like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination , 2015, Science Translational Medicine.

[13]  D. Speiser,et al.  Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells. , 2015, Cancer research.

[14]  A. Sewell,et al.  Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides , 2014, European journal of immunology.

[15]  David M. Kranz,et al.  Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies , 2013, Front. Immunol..

[16]  M. Neuenhahn,et al.  TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer , 2013, Science Translational Medicine.

[17]  P. Guillaume,et al.  Analysis, Isolation, and Activation of Antigen-Specific CD4+ and CD8+ T Cells by Soluble MHC-Peptide Complexes , 2013, Front. Immunol..

[18]  S. Rosenberg,et al.  T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy , 2013, Proceedings of the National Academy of Sciences.

[19]  J. K. Sandberg,et al.  Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response , 2013, The Journal of Immunology.

[20]  A. Sewell,et al.  Peptide length determines the outcome of TCR/peptide-MHCI engagement. , 2013, Blood.

[21]  J. Sidney,et al.  T-Cell Memory Responses Elicited by Yellow Fever Vaccine are Targeted to Overlapping Epitopes Containing Multiple HLA-I and -II Binding Motifs , 2013, PLoS neglected tropical diseases.

[22]  D. Price,et al.  A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides* , 2011, The Journal of Biological Chemistry.

[23]  D. Speiser,et al.  Reversible Major Histocompatibility Complex I-Peptide Multimers Containing Ni2+-Nitrilotriacetic Acid Peptides and Histidine Tags Improve Analysis and Sorting of CD8+ T Cells* , 2011, The Journal of Biological Chemistry.

[24]  T. Schumacher,et al.  Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function , 2010, The Journal of Immunology.

[25]  E. Lindahl,et al.  Implementation of the CHARMM Force Field in GROMACS: Analysis of Protein Stability Effects from Correction Maps, Virtual Interaction Sites, and Water Models. , 2010, Journal of chemical theory and computation.

[26]  C. Rice,et al.  The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD 8 T Cell Response 1 , 2009 .

[27]  G. Gao,et al.  Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor* , 2009, The Journal of Biological Chemistry.

[28]  D. Price,et al.  Tricks with tetramers: how to get the most from multimeric peptide–MHC , 2009, Immunology.

[29]  D. Speiser,et al.  Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen , 2008, Proceedings of the National Academy of Sciences.

[30]  Carsten Kutzner,et al.  GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. , 2008, Journal of chemical theory and computation.

[31]  Robert Maile,et al.  CD8+ T Cell Activation Is Governed by TCR-Peptide/MHC Affinity, Not Dissociation Rate1 , 2007, The Journal of Immunology.

[32]  Andrew K. Sewell,et al.  Human TCR-Binding Affinity is Governed by MHC Class Restriction1 , 2007, The Journal of Immunology.

[33]  M. Parrinello,et al.  Canonical sampling through velocity rescaling. , 2007, The Journal of chemical physics.

[34]  P. Doherty,et al.  A correlation between function and selected measures of T cell avidity in influenza virus‐specific CD8+ T cell responses , 2006, European journal of immunology.

[35]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[36]  Robert C. Edgar,et al.  MUSCLE: multiple sequence alignment with high accuracy and high throughput. , 2004, Nucleic acids research.

[37]  Roland L. Dunbrack.  Rotamer libraries in the 21st century. , 2002, Current opinion in structural biology.

[38]  D. Kranz,et al.  Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation , 2001, The Journal of experimental medicine.

[39]  D. Speiser,et al.  Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity. , 2001, Cancer research.

[40]  Alexander D. MacKerell,et al.  All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.

[41]  T. Darden,et al.  A smooth particle mesh Ewald method , 1995 .

[42]  M. Davis,et al.  Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[43]  T. Blundell,et al.  Comparative protein modelling by satisfaction of spatial restraints. , 1993, Journal of molecular biology.

[44]  Z Reich,et al.  Ligand recognition by alpha beta T cell receptors. , 1998, Annual review of immunology.