Photoacoustic tomography imaging system based on digital B-mode ultrasound diagnosis equipment.

A photoacoustic tomography imaging system with B-mode digital ultrasound diagnosis equipment was designed, fabricated, and tested for biomedical imaging. The system for biomedical diagnostics was designed with four parts consisting of an irradiating source, digital B-mode ultrasound diagnostic equipment with a liner transducer array, data acquisition and transmission system, and rotation devices for imaging scanning. Multielement phase-controlled focus technique was applied to reduce the data-acquisition time and enhance signal-to-noise ratio. Under the self-designed working sequence, data-acquisition time of an image can be reduced to 12 s. A series of experiments were performed to estimate the imaging quality of the system. The lateral and elevational resolutions of the system were detected to be 0.25 and 1.4 mm, respectively. The results show that the system has the feasibility to be used as a medical imaging method, and it may provide a new rapid and noninvasive imaging modality for clinical applications.

[1]  Da Xing,et al.  Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor. , 2007, Journal of biomedical optics.

[2]  Da Xing,et al.  Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography. , 2007, Medical physics.

[3]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[4]  Lihong V. Wang,et al.  In vivo volumetric imaging of subcutaneous microvasculature by photoacoustic microscopy. , 2006, Optics express.

[5]  Alexander A. Oraevsky,et al.  Two-dimensional optoacoustic tomography: transducer array and image reconstruction algorithm , 1999, Photonics West - Biomedical Optics.

[6]  Da Xing,et al.  Fast full-view photoacoustic imaging by combined scanning with a linear transducer array. , 2007, Optics express.

[7]  Da Xing,et al.  Photoacoustic imaging with deconvolution algorithm. , 2004, Physics in medicine and biology.

[8]  Da Xing,et al.  Fast photoacoustic imaging system based on 320-element linear transducer array. , 2004, Physics in medicine and biology.

[9]  Alexander A. Oraevsky,et al.  Laser optoacoustic imaging of the breast: detection of cancer angiogenesis , 1999, Photonics West - Biomedical Optics.

[10]  Hao Zhang,et al.  Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy , 2007 .

[11]  Lihong V. Wang,et al.  Photoacoustic imaging of lacZ gene expression in vivo. , 2007, Journal of biomedical optics.

[12]  Quan Zhou,et al.  Detection of foreign body using fast thermoacoustic tomography with a multielement linear transducer array. , 2007, Applied physics letters.

[13]  R. Kruger,et al.  Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz-feasibility study. , 2000, Radiology.

[14]  Lihong V. Wang,et al.  In vivo imaging of subcutaneous structures using functional photoacoustic microscopy , 2007, Nature Protocols.

[15]  Da Xing,et al.  Noninvasive monitoring of traumatic brain injury and post-traumatic rehabilitation with laser-induced photoacoustic imaging , 2007 .

[16]  Yi Wang,et al.  Photoacoustic and ultrasonic coimage with a linear transducer array , 2004 .

[17]  Da Xing,et al.  Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm , 2005 .

[18]  Da Xing,et al.  Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head , 2006 .