Diastolic function after cardiac and heart-lung transplantation.

The mechanical efficiency of left ventricular contraction and relaxation, the asynchrony of the onset of left ventricular relaxation, the time constant of left ventricular isovolumic pressure decay, and left ventricular chamber and myocardial stiffness were analysed in 32 patients after cardiac (24) and heart-lung transplantation (8). After cardiac transplantation left ventricular myocardial stiffness was increased and a mild degree of incoordinate contraction and relaxation was seen. In contrast, after heart-lung transplantation diastolic function was almost normal. Impairment of passive diastolic properties was significantly related to the ischaemic time of the donor heart and the donor's age. The index of left ventricular asynchrony was related to the ischaemic time and the recipient's age. The interval between transplantation and study did not influence the number of rejection episodes. This study confirms the presence of diastolic dysfunction after cardiac transplantation. Impairment of diastolic function seems to be related to the ischaemic time of the donor heart and to a mismatch between the size of the donor heart and the recipient's needs.

[1]  M. Yacoub,et al.  Cardiopulmonary response to dynamic exercise after heart and combined heart-lung transplantation. , 1989, British heart journal.

[2]  A. Khaghani,et al.  Distant organ procurement for heart and lung transplantation. , 1989, Transplantation proceedings.

[3]  G. Hausdorf,et al.  Effects of persiting myocardial sinusoids on left ventricular performance in pulmonary atresia with intact ventricular septum , 1987 .

[4]  G. Hausdorf,et al.  Effects of persisting myocardial sinusoids on left ventricular performance in pulmonary atresia with intact ventricular septum. , 1987, European heart journal.

[5]  O. Hess,et al.  Myocardial relaxation and passive diastolic properties in man. , 1986, Circulation.

[6]  J. Copeland,et al.  Myocardial function after preservation for 24 hours. , 1986, The Journal of thoracic and cardiovascular surgery.

[7]  J. Copeland,et al.  Cardiac transplant patient at one year. Cyclosporine vs conventional immunosuppression. , 1986, Chest.

[8]  R. Lanza,et al.  The effects of brain death and 24 hours' storage by hypothermic perfusion on donor heart function in the pig. , 1986, The Journal of thoracic and cardiovascular surgery.

[9]  J. Copeland,et al.  The cardiac donor: a six-year experience. , 1986, The Annals of thoracic surgery.

[10]  S. Jamieson,et al.  Combined heart-lung transplantation for end-stage Eisenmenger's syndrome. , 1986, The Journal of thoracic and cardiovascular surgery.

[11]  H. Fukuzaki,et al.  Effects of left ventricular asynchrony on time constant and extrapolated pressure of left ventricular pressure decay in coronary artery disease. , 1985, Journal of the American College of Cardiology.

[12]  S. Hunt,et al.  Long-term results, hemodynamics, and complications after combined heart and lung transplantation. , 1985, Circulation.

[13]  M. Yacoub,et al.  Left ventricular contractility and contractile reserve in humans after cardiac transplantation. , 1985, Circulation.

[14]  D. Cooley,et al.  Cardiac transplantation at the Texas Heart Institute: comparative analysis of two groups of patients (1968-1969 and 1982-1983). , 1985, The Annals of thoracic surgery.

[15]  Mark L. Greenberg,et al.  Long-term hemodynamic follow-up of cardiac transplant patients treated with cyclosporine and prednisone. , 1985, Circulation.

[16]  R. Hetzer,et al.  Heart transplantation--a two-year experience. , 1985, Zeitschrift fur Kardiologie.

[17]  M. Yacoub,et al.  Cardiac transplantation--the London experience. , 1985, Zeitschrift fur Kardiologie.

[18]  S. Hagl,et al.  Heart transplantation: limitations and perspectives. , 1985, Zeitschrift fur Kardiologie.

[19]  O. Hess,et al.  Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement. , 1984, Circulation.

[20]  C. B. Waldron,et al.  Estimation of time constant of left ventricular relaxation. , 1983, British heart journal.

[21]  B. Griffith,et al.  Cardiac Transplants With Cyclosporin-A and Low-Dose Prednisone: Histologic Graduation of Rejection. , 1983, Transplantation proceedings.

[22]  C. B. Waldron,et al.  Analysis of Left Ventricular Pressure During Isovolumic Relaxation in Coronary Artery Disease , 1982, Circulation.

[23]  O. Hess,et al.  Diastolic Function and Myocardial Structure in Patients with Myocardial Hypertrophy: Special Reference to Normalized Viscoelastic Data , 1981, Circulation.

[24]  G. Daughters,et al.  Exercise response of the denervated heart in long-term cardiac transplant recipients. , 1980, The American journal of cardiology.

[25]  D. Gibson,et al.  Relation of isovolumic relaxation to left ventricular wall movement in man. , 1979, British heart journal.

[26]  O. Hess,et al.  Diastolic Simple Elastic and Viscoelastic Properties of the Left Ventricle in Man , 1979, Circulation.

[27]  J. Weiss,et al.  Evidence of incomplete left ventricular relaxation in the dog: prediction from the time constant for isovolumic pressure fall. , 1978, The Journal of clinical investigation.

[28]  Randolph P. Martin,et al.  The Effect of Exercise and Atrial Pacing on Left Ventricular Volume and Contractility in Patients with Innervated and Denervated Hearts , 1978, Circulation.

[29]  D. Gibson,et al.  The study of left ventricular function from digitized echocardiograms. , 1978, Progress in cardiovascular diseases.

[30]  J. Lewicki,et al.  Resolution of Multiple Forms of Human Angiotensinogen Isoelectric Focusing Heterogeneity Profile Analysis , 1977, Circulation research.

[31]  Anderson,et al.  Viscoelastic properties of the diastolic left ventricle in the conscious dog. , 1977, Circulation research.

[32]  W Grossman,et al.  Diastolic properties of the left ventricle. , 1976, Annals of internal medicine.

[33]  D. Gibson,et al.  Assessment of left ventricular systolic function in man from simultaneous echocardiographic and pressure measurements. , 1976, British heart journal.

[34]  M. Morad,et al.  Relaxing effects of catecholamines on mammalian heart , 1972, The Journal of physiology.

[35]  D. Cokkinos,et al.  Serial hemodynamic study of the transplanted heart and correlation with clinical rejection. , 1971, The Journal of thoracic and cardiovascular surgery.

[36]  G. Lepage,et al.  Cardiac catheterization findings at rest and after exercise in patients following cardiac transplantation. , 1970, The American journal of cardiology.