Long‐term prognosis of young patients after myocardial infarction in the thrombolytic era

Background: Myocardial infarction (MI) in young adults is a rare event. In the Framingham study, the 10‐year incidence rate of MI per 1,000 was 12.9 in men 30–34 years old. Overall, 4–8% of patients with acute MI are ≤ 40 years old.

[1]  E. Topol,et al.  Multiple vessel coronary angioplasty: classification, results, and patterns of restenosis in 494 consecutive patients. , 1987, Catheterization and cardiovascular diagnosis.

[2]  L. Fisher,et al.  Myocardial infarction in young adults: angiographic characterization, risk factors and prognosis (Coronary Artery Surgery Study Registry). , 1995, Journal of the American College of Cardiology.

[3]  S. Chierchia,et al.  Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina. , 1978, The New England journal of medicine.

[4]  P. B. Oliva,et al.  Acute myocardial infarction with normal and near normal coronary arteries. Documentation with coronary arteriography within 12 1/2 hours of the onset of symptoms in two cases (three episodes). , 1977, The American journal of cardiology.

[5]  R. Norris,et al.  Prognosis after myocardial infarction: results of 15 year follow up. , 1984, British medical journal.

[6]  B. Salem,et al.  Acute myocardial infarction with "normal" coronary arteries: clinical and angiographic profiles, with ergonovine testing. , 1985, Texas Heart Institute journal.

[7]  E. Gilpin,et al.  Myocardial infarction in young patients: an analysis by age subsets. , 1986, Circulation.

[8]  E. Gilpin,et al.  First myocardial infarction: age and ejection fraction identify a low-risk group. , 1988, American heart journal.

[9]  R. Diaz,et al.  Acute myocardial infarction in the young--the role of smoking. The Investigators of the International Tissue Plasminogen Activator/Streptokinase Mortality Trial. , 1995, European heart journal.

[10]  S. Yusuf,et al.  Does PTCA in acute myocardial infarction affect mortality and reinfarction rates? A quantitative overview (meta-analysis) of the randomized clinical trials. , 1995, Circulation.

[11]  J. Vacek,et al.  Myocardial infarction in the young. Angiographic features and risk factor analysis of patients with myocardial infarction at or before the age of 35 years. , 1988, Chest.

[12]  S. Willich,et al.  Factors leading to shorter survival after acute myocardial infarction in patients ages 65 to 75 years compared with younger patients. , 1988, The American journal of cardiology.

[13]  B. Bulkley,et al.  Multiple coronary thromboses in previously normal coronary arteries: a rare cause of acute myocardial infarction. , 1980, American heart journal.

[14]  L. Kuller,et al.  Age-related prognosis after acute myocardial infarction (the Multicenter Diltiazem Postinfarction Trial). , 1990, The American journal of cardiology.

[15]  F. Burkart,et al.  Angiographic Findings in Postinfarction Patients Under the Age of 35 , 1981 .

[16]  G. Uhl,et al.  Myocardial Infarction at Young Age: Risk Factors and Natural History , 1981 .

[17]  G. Lamm The Epidemiology of Acute Myocardial Infarction in Young Age Groups , 1981 .

[18]  K. Lee,et al.  Age and outcome with contemporary thrombolytic therapy. Results from the GUSTO-I trial. Global Utilization of Streptokinase and TPA for Occluded coronary arteries trial. , 1996, Circulation.

[19]  D. Waters,et al.  Coronary artery disease in young women: clinical and angiographic features and correlation with risk factors. , 1978, The American journal of cardiology.

[20]  R. Virmani,et al.  Myocardial Infarction in Patients Under the Age of 40 Autopsy Findings , 1981 .

[21]  S. Warren,et al.  Myocardial infarction before age 36: risk factor and arteriographic analysis. , 1982, The American journal of cardiology.

[22]  F. Werf Thrombolysis for acute myocardial infarction. Why is there no extra benefit after hospital discharge? , 1995, Circulation.

[23]  F. Van de Werf,et al.  The risk of stroke in patients with acute myocardial infarction after thrombolytic and antithrombotic treatment. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico II (GISSI-2), and The International Study Group. , 1992, The New England journal of medicine.

[24]  E. Lesaffre,et al.  Multivariate survival analysis for the assessment of prognostic factors and risk categories after recovery from acute myocardial infarction: the Belgian situation. , 1985, American journal of epidemiology.

[25]  Richard P. Lewis,et al.  ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). , 1996, Journal of the American College of Cardiology.

[26]  J. Wei,et al.  Myocardial infarction before age 36 years in women: predominance of apparent nonatherosclerotic events. , 1982, American heart journal.

[27]  R. Bergstrand,et al.  Myocardial Infarction Among Men Below Age 40 in Göteborg , 1981 .

[28]  G. Vincent,et al.  Coronary spasm producing coronary thrombosis and myocardial infarction. , 1983, The New England journal of medicine.

[29]  W. C. Sheldon,et al.  Coronary Arteriographic Findings in Younger Survivors of Acute Myocardial Infarction Including Those with Normal Coronary Arteries , 1981 .

[30]  S. Warren,et al.  Historic and angiographic features of young adults surviving myocardial infarction. , 1979, Chest.

[31]  Johan Herlitz,et al.  Indications for fibrinolytic therapy in suspected acute myocardial infarction : collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients , 1994 .

[32]  O. Roth,et al.  Long range observations in fifty-three young patients with myocardial infarction. , 1967, The American journal of cardiology.

[33]  W. Kannel,et al.  Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. , 1984, The New England journal of medicine.

[34]  Fibrinolytictherapytrialistsf Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients , 1994 .

[35]  M. Robins,et al.  Initial myocardial infarction among 503 veterans: five-year survival. , 1960, The American journal of medicine.

[36]  Kennelly Bm Aetiology and risk factors in young patients with recent acute myocardial infarction. , 1982 .

[37]  D. Kelly,et al.  Coronary Anatomy and Prognosis After Myocardial Infarction in Patients 60 Years of Age and Younger , 1983, Circulation.

[38]  H. Gohlke,et al.  Coronary Angiographic Findings and Risk Factors in Postinfarction Patients Under the Age of 40 , 1981 .

[39]  G. Gregoratos,et al.  Coronary artery disease in young patients: arteriographic and clinical review of 40 cases aged 35 and under. , 1974, American heart journal.

[40]  M. Oliver,et al.  Myocardial infarction in young men. Study of risk factors in nine countries. , 1975, British heart journal.

[41]  R. Mulcahy,et al.  Natural history of coronary heart disease: a study of 586 men surviving an initial acute attack. , 1983, American Heart Journal.

[42]  J. Alpert,et al.  Incidence and age distribution of patients with myocardial infarction and normal coronary arteriograms. , 1977, Catheterization and cardiovascular diagnosis.