Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury.

[1]  J. Falck,et al.  Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function , 2006, Circulation research.

[2]  J. Falck,et al.  Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. , 2006, American journal of physiology. Heart and circulatory physiology.

[3]  P. Wolf,et al.  Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2006, Circulation.

[4]  J. Falck,et al.  Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. , 2006, American journal of physiology. Heart and circulatory physiology.

[5]  M. Fornage,et al.  Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. , 2006, Human molecular genetics.

[6]  M. Fornage,et al.  The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. , 2005, Human molecular genetics.

[7]  R. Hui,et al.  Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways , 2005, Journal of Pharmacology and Experimental Therapeutics.

[8]  J. Daut,et al.  K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms. , 2005, Journal of molecular and cellular cardiology.

[9]  R. Cannon Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction , 2005, Nature Clinical Practice Cardiovascular Medicine.

[10]  H. Nakaya,et al.  Mitochondrial Ca2+-Activated K+ Channels in Cardiac Myocytes: A Mechanism of the Cardioprotective Effect and Modulation by Protein Kinase A , 2005, Circulation.

[11]  D. Kroetz,et al.  REGULATION AND INHIBITION OF ARACHIDONIC ACID ω-HYDROXYLASES AND 20-HETE FORMATION , 2005 .

[12]  D. Kroetz,et al.  Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. , 2005, Annual review of pharmacology and toxicology.

[13]  B. Hammock,et al.  Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. , 2005, Annual review of pharmacology and toxicology.

[14]  B. Hammock,et al.  Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. , 2004, American journal of physiology. Heart and circulatory physiology.

[15]  J. Falck,et al.  Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. , 2004, Journal of molecular and cellular cardiology.

[16]  J. Falck,et al.  Enhancement of Cardiac L-Type Ca2+ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2 , 2004, Molecular Pharmacology.

[17]  Xiaoying Wang,et al.  Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice. , 2004, American journal of physiology. Heart and circulatory physiology.

[18]  J. Falck,et al.  Inhibition of Cytochrome P450&ohgr;-Hydroxylase: A Novel Endogenous Cardioprotective Pathway , 2004, Circulation research.

[19]  K. Lindpaintner,et al.  Risk of Coronary Artery Disease Associated With Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 , 2004, Circulation.

[20]  J. Foley,et al.  Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway , 2004, Circulation research.

[21]  A. Halestrap Mitochondrial permeability: Dual role for the ADP/ATP translocator? , 2004, Nature.

[22]  Hiromu Tanimoto,et al.  Experimental psychology: Event timing turns punishment to reward , 2004, Nature.

[23]  E. Marbán,et al.  Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  R. Bolli,et al.  Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy , 2004, Circulation research.

[25]  I. Fleming Cytochrome P450 epoxygenases as EDHF synthase(s). , 2004, Pharmacological research.

[26]  E. Olson,et al.  Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore , 2004 .

[27]  DerekHausenloy,et al.  Transient Mitochondrial Permeability Transition Pore Opening Mediates Preconditioning-Induced Protection , 2004 .

[28]  M. Duchen,et al.  Transient Mitochondrial Permeability Transition Pore Opening Mediates Preconditioning-Induced Protection , 2004, Circulation.

[29]  B. O’Rourke,et al.  Evidence for Mitochondrial K Channels and Their Role in Cardioprotection , 2004 .

[30]  S. Javadov,et al.  Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. , 2004, Cardiovascular research.

[31]  M. Yeager,et al.  Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Fornage,et al.  Polymorphism of the Soluble Epoxide Hydrolase Is Associated With Coronary Artery Calcification in African-American Subjects: The Coronary Artery Risk Development In Young Adults (CARDIA) Study , 2004, Circulation.

[33]  E. Murphy,et al.  Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. , 2004, Circulation research.

[34]  Xiang Fang,et al.  Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. , 2004, Progress in lipid research.

[35]  E. Olson,et al.  Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. , 2004, The Journal of clinical investigation.

[36]  M. Duchen,et al.  Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. , 2003, Cardiovascular research.

[37]  U. de Faire,et al.  Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction. , 2003, Pharmacogenetics.

[38]  D. Zeldin,et al.  Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways , 2003, Journal of Pharmacology and Experimental Therapeutics.

[39]  J. Downey,et al.  Preconditioning the myocardium: from cellular physiology to clinical cardiology. , 2003, Physiological reviews.

[40]  G. Gross,et al.  KATP channels and myocardial preconditioning: an update. , 2003, American journal of physiology. Heart and circulatory physiology.

[41]  Peipei Ping,et al.  Role of the mitochondrial permeability transition in myocardial disease. , 2003, Circulation research.

[42]  D. Manuel,et al.  Burden of cardiovascular disease in Canada. , 2003, The Canadian journal of cardiology.

[43]  J. E. Maxwell,et al.  Polymorphisms in human soluble epoxide hydrolase. , 2003, Molecular pharmacology.

[44]  P. Austin,et al.  Outcomes of acute myocardial infarction in Canada. , 2003, The Canadian journal of cardiology.

[45]  J. Tu,et al.  Impact of an acute myocardial infarction report card in Ontario, Canada. , 2003, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[46]  D. Manuel,et al.  Cause-deleted health-adjusted life expectancy of Canadians with selected chronic conditions. , 2003, Chronic diseases in Canada.

[47]  Yongge Liu,et al.  Cytoprotective Role of Ca2+- Activated K+ Channels in the Cardiac Inner Mitochondrial Membrane , 2002, Science.

[48]  T. Lu,et al.  Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: a structural determinant study. , 2002, Molecular pharmacology.

[49]  V. Calderone Large-conductance, ca(2+)-activated k(+) channels: function, pharmacology and drugs. , 2002, Current medicinal chemistry.

[50]  A. Wickenden K(+) channels as therapeutic drug targets. , 2002, Pharmacology & therapeutics.

[51]  Peipei Ping,et al.  Expression of Activated PKC Epsilon (PKC ϵ) Protects the Ischemic Heart, without Attenuating Ischemic H+ Production , 2002 .

[52]  R. Roman,et al.  P-450 metabolites of arachidonic acid in the control of cardiovascular function. , 2002, Physiological reviews.

[53]  P. Ping,et al.  Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production. , 2002, Journal of molecular and cellular cardiology.

[54]  T. Lu,et al.  Activation of ATP‐sensitive K+ channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes , 2001, The Journal of physiology.

[55]  D. Zeldin Epoxygenase Pathways of Arachidonic Acid Metabolism* , 2001, The Journal of Biological Chemistry.

[56]  J. Falck,et al.  Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. , 2001, Molecular pharmacology.

[57]  K. Node,et al.  Activation of Gαs Mediates Induction of Tissue-type Plasminogen Activator Gene Transcription by Epoxyeicosatrienoic Acids* , 2001, The Journal of Biological Chemistry.

[58]  D. Thompson,et al.  Pathways of Epoxyeicosatrienoic Acid Metabolism in Endothelial Cells , 2001, The Journal of Biological Chemistry.

[59]  R. Busse,et al.  Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries , 2001, Circulation research.

[60]  D. Harder,et al.  Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. , 2001, Trends in cardiovascular medicine.

[61]  R. Roman,et al.  Renal And Cardiovascular Actions Of 20‐Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids , 2000, Clinical and experimental pharmacology & physiology.

[62]  M. Stern,et al.  Protective effects of low and high doses of cyclosporin A against reoxygenation injury in isolated rat cardiomyocytes are associated with differential effects on mitochondrial calcium levels. , 2000, Cell calcium.

[63]  Michael V. Cohen,et al.  Protein Kinase C- ξ is Responsible for the Protection of Preconditioning in Rabbit Cardiomyocytes , 1999 .

[64]  R. Busse,et al.  Cytochrome P450 2C is an EDHF synthase in coronary arteries , 1999, Nature.

[65]  K. Ley,et al.  Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. , 1999, Science.

[66]  T. Lu,et al.  Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes , 1999, The Journal of physiology.

[67]  M Crompton,et al.  The mitochondrial permeability transition pore and its role in cell death. , 1999, The Biochemical journal.

[68]  A. Szewczyk,et al.  Mitochondrial ATP‐Dependent Potassium Channels: Viable Candidate Effectors of Ischemic Preconditioning a , 1999, Annals of the New York Academy of Sciences.

[69]  Yongge Liu,et al.  Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels. , 1999, Molecular pharmacology.

[70]  R. Fryer,et al.  Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. , 1999, Circulation research.

[71]  J. Borecký,et al.  Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line. , 1999, Biochemical and biophysical research communications.

[72]  W. Campbell,et al.  Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. , 1999, Circulation research.

[73]  J. Downey,et al.  Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. , 1999, Journal of molecular and cellular cardiology.

[74]  Yongge Liu,et al.  Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? , 1998, Circulation.

[75]  L. Huang,et al.  Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells , 1998, The Journal of physiology.

[76]  J. Phillis,et al.  Role of phospholipase A2 in the release of free fatty acids during ischemia-reperfusion in the rat cerebral cortex , 1997, Neuroscience Letters.

[77]  K. Tomer,et al.  Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes* , 1997, The Journal of Biological Chemistry.

[78]  J. Zhang,et al.  Economic burden of illness in Canada, 1993. Executive summary and recommendations. , 1997, Chronic diseases in Canada.

[79]  P. Pratt,et al.  Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. , 1996, Circulation research.

[80]  K. Tomer,et al.  Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart (*) , 1996, The Journal of Biological Chemistry.

[81]  R. DuBois,et al.  Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. , 1995, Archives of biochemistry and biophysics.

[82]  A. Halestrap,et al.  Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. , 1993, Journal of molecular and cellular cardiology.

[83]  M. Karmazyn,et al.  Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. , 1993, The American journal of physiology.

[84]  D. Zeldin,et al.  Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. , 1993, The Journal of biological chemistry.

[85]  M. Nelson,et al.  Regulation of arterial tone by activation of calcium-dependent potassium channels. , 1992, Science.

[86]  M. Crompton,et al.  Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A. , 1991, Journal of molecular and cellular cardiology.