The Applications Of Fluorine-19 NMR In Medicine

The current research, potential applications, and utilization of 19F-NMR techniques in medicine and biomedical studies are reviewed. The wide ranging possibilities involving spectroscopy and/or imaging include investigations of: metabolic processes using fluorine labeled substrates; enzymatic activity, reaction mechanisms and biomolecular binding; membrane and cell systems; perfluorocarbon compound utility; biodistribution and retention of fluorinated materials including anesthetics; and, gas phase applications.

[1]  A. Wyrwicz,et al.  Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance , 1983 .

[2]  P. Allen,et al.  The influence of oxygenation on the 19F spin-lattice relaxation rates of fluosol-DA. , 1985, Physics in medicine and biology.

[3]  B. Sykes,et al.  Energetics of the equilibrium between two nucleotide-free myosin subfragment 1 states using fluorine-19 nuclear magnetic resonance. , 1982, Biochemistry.

[4]  J G Kereiakes,et al.  Nuclear magnetic resonance imaging techniques as developed modestly within a university medical center environment: what can the small system contribute at this point? , 1982, Magnetic resonance imaging.

[5]  F. Dahlquist,et al.  19F nuclear magnetic resonance observations of aldehyde dismutation catalyzed by horse liver alcohol dehydrogenase. , 1982, Archives of biochemistry and biophysics.

[6]  B. Sykes,et al.  19F nuclear magnetic resonance studies of the coat protein of bacteriophage M13 in synthetic phospholipid vesicles and deoxycholate micelles. , 1982, Biophysical journal.

[7]  S E Seltzer,et al.  In vivo 19F NMR imaging of liver, tumor, and abscess in rats. Preliminary results. , 1985, Investigative radiology.

[8]  T. Nakada,et al.  19-Fluorine nuclear magnetic resonance spectra of 2-fluoro-2-deoxy-D-glucose and its metabolites , 1985 .

[9]  J. Griffiths,et al.  5-fluorouracil metabolism monitored in vivo by 19F NMR. , 1984, British Journal of Cancer.

[10]  B. Sykes,et al.  Fluorine-19 nuclear magnetic resonance studies of lipid fatty acyl chain order and dynamics in Acholeplasma laidlawii B membranes. Gel-state disorder in the presence of methyl iso- and anteiso-branched-chain substituents. , 1985, Biochemistry.

[11]  P. Joseph,et al.  In Vivo 19F NMR Imaging of the Cardiovascular System , 1985, Journal of computer assisted tomography.

[12]  G A Smith,et al.  Free cytosolic Ca2+ measurements with fluorine labelled indicators using 19FNMR. , 1985, Cell calcium.

[13]  K. Matsui,et al.  8-Fluoro-8-demethylriboflavin as a 19F-probe for flavin-protein interaction. A 19F NMR study with egg white riboflavin binding protein. , 1983, Biochemical and biophysical research communications.

[14]  J. Armand,et al.  Complete urinary excretion profile of 5-fluorouracil during a six-day chemotherapeutic schedule, as resolved by 19F nuclear magnetic resonance. , 1985, Clinical chemistry.

[15]  G. Peersman,et al.  Chemical shift imaging. , 1988, Journal belge de radiologie.

[16]  J S Fowler,et al.  Radiopharmaceuticals XXVII. 18F-labeled 2-deoxy-2-fluoro-d-glucose as a radiopharmaceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in animals. , 1977, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  T. Nakada,et al.  Noninvasive In Vivo Demonstration of 2‐Fluoro‐2‐Deoxy‐d‐Glucose Metabolism Beyond the Hexokinase Reaction in Rat Brain by 19F Nuclear Magnetic Resonance Spectroscopy , 1986, Journal of neurochemistry.

[18]  L. C. Clark,et al.  The solubility of oxygen in highly fluorinated liquids , 1977 .

[19]  T. Nelson,et al.  Fluorine nuclear magnetic resonance: calibration and system optimization. , 1985, Magnetic resonance imaging.

[20]  Application of 19F NMR spectroscopy to a study of carbon monoxide binding to human hemoglobin modified at Cys-beta 93 with the S-trifluoroethyl residue. , 1984, Archives of biochemistry and biophysics.

[21]  Robert R. Moore,et al.  Fluorinated anesthetics as probes of lipophilic environments in tumors , 1983 .

[22]  B. Fung,et al.  Fluorine-19 relaxation study of perfluoro chemicals as oxygen carriers , 1983 .

[23]  R. Shafer,et al.  Binding of 5-fluorotryptamine to polynucleotides as a model for protein-nucleic acid interactions: fluorine-19 nuclear magnetic resonance, absorption, and fluorescence studies. , 1982, Biochemistry.

[24]  J. Armand,et al.  Detection of fluoropyrimidines and their metabolites in biological samples by fluorine-19 NMR: application to 5'-deoxy-5-fluorouridine. , 1983, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[25]  G. Rotilio,et al.  Nuclear magnetic relaxation of 19F as a novel assay method of superoxide dismutase. , 1979, The Journal of biological chemistry.

[26]  R. Martino,et al.  Fluosol 43 intravascular persistence in mice measured by 19F nmr , 1984, The Journal of pharmacy and pharmacology.

[27]  C. Ho,et al.  Fluorine-19 nuclear magnetic resonance study of 5-fluorotryptophan-labeled histidine-binding protein J of Salmonella typhimurium. , 1984, Journal of molecular biology.

[28]  J. Ackerman,et al.  Perfluorinated organic liquids and emulsions as biocompatible NMR imaging agents for 19F and dissolved oxygen. , 1984, Advances in experimental medicine and biology.

[29]  M. L. Bender,et al.  Fluorine magnetic resonance studies of fluorine-substituted benzoyl chymotrypsins. , 1983, Archives of biochemistry and biophysics.

[30]  J. Mazziotta,et al.  Positron emission tomography: human brain function and biochemistry. , 1985, Science.

[31]  G. Rotilio,et al.  F19 relaxation as a probe of the oxidation state of Cu, Zn superoxide dismutase. Studies of the enzyme in steady-state turnover. , 1981, Biochemical and biophysical research communications.

[32]  F. Poulsen,et al.  Studies of human platelets by 19F and 31P NMR , 1979, FEBS letters.

[33]  F. Gollan,et al.  Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure , 1966, Science.

[34]  J. T. Gerig,et al.  Fluorine NMR studies of fluorocinnamoylchymotrypsins. , 1981, Archives of biochemistry and biophysics.

[35]  David F Wilson,et al.  Measurement of transmembrane pH gradients in human erythrocytes using 19F NMR. , 1981, Analytical biochemistry.

[36]  L. C. Clark,et al.  Perfluorocarbons Having a Short Dwell Time in the Liver , 1973, Science.

[37]  W. Edelstein,et al.  NMR imaging applications in medicine and biology. , 1982, Current problems in cancer.

[38]  M. Civan,et al.  Intracellular pH of perfused single frog skin: combined 19F- and 31P-NMR analysis. , 1984, The American journal of physiology.

[39]  L. J. Busse,et al.  MR imaging of the lung using liquid perfluorocarbons. , 1986, Journal of computer assisted tomography.

[40]  J. S. Hyde,et al.  Effect of oxygen and the lipid spin label TEMPO-laurate on fluorine-19 and proton relaxation rates of the perlluoroehemical blood substitute, FC-43 emulsion , 1984 .

[41]  H L Kundel,et al.  Magnetic resonance imaging of fluorine in rats infused with artificial blood. , 1985, Investigative radiology.

[42]  V. Simplaceanu,et al.  Fluorine-19 nuclear magnetic resonance investigation of fluorine-19-labeled phospholipids. 2. A line-shape analysis. , 1984, Biochemistry.

[43]  Fluoride ion as an NMR relaxation probe of galactose oxidase-substrate binding. , 1981, Biochimica et biophysica acta.

[44]  V. Simplaceanu,et al.  Nuclear magnetic resonance line-shape analysis of fluorine-19-labeled phospholipids. , 1982, Biochemistry.