Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis

Abstract. Salonen JT, Nyyssönen K, Salonen R, Lakka H‐M, Kaikkonen J, Porkkala‐Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, tuomainen T‐P, Valkonen V‐P, Ristonmaa U (University of Kuopio, Finland), Poulsen HE (University of Copenhagen, Copenhagen, Denmark). Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis. J Intern Med 2000; 248: 377–386.

[1]  J. Freedman,et al.  Vitamin E and vascular homeostasis: implications for atherosclerosis , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  J. Yoshikawa,et al.  Antioxidants improve impaired insulin-mediated glucose uptake and prevent migration and proliferation of cultured rabbit coronary smooth muscle cells induced by high glucose. , 1999, Circulation.

[3]  P. Ganz,et al.  Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function. , 1999, Circulation.

[4]  J. Keaney,et al.  Antioxidants and atherosclerotic heart disease. , 1997, The New England journal of medicine.

[5]  P. Ganz,et al.  Plasma α-Tocopherol and Coronary Endothelium-Dependent Vasodilator Function , 1999 .

[6]  D. Tribble.  AHA Science Advisory. Antioxidant consumption and risk of coronary heart disease: emphasison vitamin C, vitamin E, and beta-carotene: A statement for healthcare professionals from the American Heart Association. , 1999, Circulation.

[7]  J. Salonen.  Epidemiological studies on antioxidants, lipid peroxidation and atherosclerosis. , 1998, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

[8]  J. Salonen,et al.  Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. , 1995, Circulation.

[9]  I. Sartori.  Relation of Leisure-Time Physical Activity and Cardiorespiratory Fitness to the Risk of Acute Myocardial Infarction in Men: , 1996 .

[10]  D. Tribble.  Antioxidant Consumption and Risk of Coronary Heart Disease: Emphasis on Vitamin C, Vitamin E, and β-Carotene A Statement for Healthcare Professionals From the American Heart Association , 1999 .

[11]  B. Ames,et al.  Ascorbate is an outstanding antioxidant in human blood plasma. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Eary,et al.  CAROTID-ARTERY INTIMA AND MEDIA THICKNESS AS A RISK FACTOR FOR MYOCARDIAL INFARCTION AND STROKE IN OLDER ADULTS , 2000 .

[13]  J. Packer,et al.  Direct observation of a free radical interaction between vitamin E and vitamin C , 1979, Nature.

[14]  J. Salonen,et al.  A randomized, single-blind, placebo-controlled trial of the effects of 200 mg (cid:97) -tocopherol on the oxidation resistance of atherogenic lipoproteins 1–3 , 1999 .

[15]  S. Clément,et al.  Molecular basis of α‐tocopherol control of smooth muscle cell proliferation , 1998 .

[16]  J. Salonen,et al.  First myocardial infarction in patients of Indian subcontinent and European origin: comparison of risk factors, management, and long term outcome , 1997, BMJ.

[17]  A. Diplock.  Will the 'good fairies' please prove to us that vitamin E lessens human degenerative disease? , 1997, Free radical research.

[18]  S. Clément,et al.  Molecular basis of alpha-tocopherol control of smooth muscle cell proliferation. , 1998, BioFactors.

[19]  E. Niki,et al.  Vitamin E protects against polymorphonuclear leukocyte‐dependent adhesion to endothelial cells , 1999, Journal of leukocyte biology.

[20]  J. Salonen,et al.  Ultrasound B-mode imaging in observational studies of atherosclerotic progression. , 1993, Circulation.

[21]  R. Kronmal,et al.  Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. , 1999, The New England journal of medicine.

[22]  S. Yusuf,et al.  Evidence based cardiology: emerging approaches in preventing cardiovascular disease. , 1999, BMJ.

[23]  J. Salonen,et al.  Autoantibody against oxidised LDL and progression of carotid atherosclerosis , 1992, The Lancet.

[24]  R. Stocker,et al.  Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. , 1997, Free radical biology & medicine.

[25]  Massimo Pandolfo,et al.  Molecular Basis , 2022 .

[26]  J. Salonen,et al.  Lipoprotein oxidation and progression of carotid atherosclerosis. , 1997, Circulation.

[27]  R H Selzer,et al.  Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound images. , 1994, Atherosclerosis.

[28]  B. Halliwell,et al.  Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? , 1994, The Lancet.

[29]  J. Salonen,et al.  Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation , 1997, European Journal of Clinical Nutrition.