Metabolism and Distribution of 131 I-labelled Albumin in the Pig*

SUMMARY The biological behaviour of porcine 1311-al- bumin has been investigated in 11 normal pigs, weight appr. 20 kg. Mean values obtained from the experiments are: Albumin degradation: 15.1 + 2.1 per cent/day (0.18 + 0.01 g/ kg/day), extravascular: intravascular albumin ratio: 1.71 + 0.29. Fecal excretion of radio-activity ranged from 0.77-1.87 per cent of the dose (mean: 1.11 per cent) during the first 4 days of the experiment. The results are discussed with special reference to the role of the gastrointestinal tract in health and in various digestive disor- ders.

[1]  L. Plantin,et al.  Catabolism and distribution of albumin in gastric cancer. , 2009, Acta Medica Scandinavica.

[2]  N. A. Haydar,et al.  PROTEIN LOSING GASTROENTEROPATHY. , 1964, Le Journal medical libanais. The Lebanese medical journal.

[3]  A. Mcfarlane,et al.  Catabolism of plasma-proteins. , 1963 .

[4]  S. Jarnum,et al.  The albumin transfer from blood to gastrointestinal tract in dogs. , 1962, Acta chirurgica Scandinavica.

[5]  J. Douglas,et al.  Distribution and turnover of iodine-131-tagged bovine albumin in normal and parasitized cattle. , 1962, American journal of veterinary research.

[6]  M. Sleisenger,et al.  Plasma proteins and the gastrointestinal tract. , 1962, The New England journal of medicine.

[7]  D P CUTHBERTSON,et al.  Passage of plasma albumin into the intestine of the sheep , 1961, The Journal of physiology.

[8]  S. Margen,et al.  CATABOLISM OF PLASMA PROTEIN IN THE GUT * , 1961, Annals of the New York Academy of Sciences.

[9]  K. Jeejeebhoy,et al.  The measurement of gastrointestinal protein loss by a new method , 1961, Gut.

[10]  A. Mcfarlane,et al.  Metabolism of I-131-labelled human albumin. , 1961, Clinical science.

[11]  J. Katz,et al.  Plasma Albumin Catabolism in Tissue Slices.∗ , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[12]  S. Margen,et al.  Plasma Protein VII. Site of Degradation of Serum Albumin.∗ , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[13]  R. S. Gordon.  Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone. , 1959, Lancet.

[14]  A. Mcfarlane,et al.  Efficient Trace-labelling of Proteins with Iodine , 1958, Nature.

[15]  F. Dixon,et al.  Half-Lives of Homologous Serum Albumins in Several Species.∗ , 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[16]  K. Sterling.  The turnover rate of serum albumin in man as measured by I131-tagged albumin. , 1951, The Journal of clinical investigation.

[17]  T. Waldmann.  Gastrointestinal protein loss demonstrated by Cr-51-labelled albumin. , 1961, Lancet.

[18]  M. Kleiber,et al.  The use of glycine 1-C14 in the measurement of serum protein turnover rates in dairy cows. , 1959, American journal of veterinary research.