Raddeanin A promotes autophagy-induced apoptosis by inactivating PI3K/AKT/mTOR pathway in lung adenocarcinoma cells.

[1]  E. Pourkarimi,et al.  Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy , 2021, International Journal of Molecular Sciences.

[2]  Fei Li,et al.  New insights into the mechanism of hepatocyte apoptosis induced by typical organophosphate ester: An integrated in vitro and in silico approach. , 2021, Ecotoxicology and environmental safety.

[3]  Qiming Wang,et al.  MEK inhibitors for the treatment of non-small cell lung cancer , 2021, Journal of Hematology & Oncology.

[4]  A. Jemal,et al.  Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.

[5]  Yong-peng Wang,et al.  LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377/CCND2/MEK/MAPK Axis. , 2020, Archives of medical research.

[6]  Xiumin Lin,et al.  Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling , 2020, Journal of oncology.

[7]  H. Bian,et al.  Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells. , 2020, Pathology, research and practice.

[8]  W. Shen,et al.  Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling , 2020, Signal Transduction and Targeted Therapy.

[9]  A. Mangerich,et al.  The Nucleolus and PARP1 in Cancer Biology , 2020, Cancers.

[10]  W. El-Deiry,et al.  Targeting apoptosis in cancer therapy , 2020, Nature Reviews Clinical Oncology.

[11]  K. Ahn,et al.  Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel , 2020, Molecules.

[12]  A. Tan.  Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC) , 2020, Thoracic cancer.

[13]  Fangzhou Song,et al.  Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  Jing Liu,et al.  Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy , 2019, Applied Microbiology and Biotechnology.

[15]  Jing Liu,et al.  Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth , 2019, Cancer Cell International.

[16]  D. V. Von Hoff,et al.  Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. , 2019, JAMA oncology.

[17]  Xiaodong Jiang,et al.  Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo , 2019, Evidence-based complementary and alternative medicine : eCAM.

[18]  Olga I Lavrik,et al.  Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins , 2019, Nucleic acids research.

[19]  J. Yap,et al.  Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers , 2019, Nature Medicine.

[20]  P. Gimotty,et al.  Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma , 2019, Clinical Cancer Research.

[21]  D. Rubinsztein,et al.  The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A , 2018, Developmental cell.

[22]  J. Zenklusen,et al.  SnapShot: TCGA-Analyzed Tumors , 2018, Cell.

[23]  Yang Zhang,et al.  Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway , 2018, Molecular medicine reports.

[24]  Yi-di Guan,et al.  Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro , 2017, Acta Pharmacologica Sinica.

[25]  R. Amaravadi,et al.  Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors , 2017, International journal of molecular sciences.

[26]  Xia Wang,et al.  PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database , 2017, Nucleic Acids Res..

[27]  Zhao-Qi Wang,et al.  PARPing for balance in the homeostasis of poly(ADP-ribosyl)ation. , 2017, Seminars in cell & developmental biology.

[28]  Ying-ying Zhang,et al.  Autophagy Protects from Raddeanin A-Induced Apoptosis in SGC-7901 Human Gastric Cancer Cells , 2016, Evidence-based complementary and alternative medicine : eCAM.

[29]  Kwok-Kin Wong,et al.  Non-small-cell lung cancers: a heterogeneous set of diseases , 2014, Nature Reviews Cancer.

[30]  Aurélien Grosdidier,et al.  SwissTargetPrediction: a web server for target prediction of bioactive small molecules , 2014, Nucleic Acids Res..

[31]  Kai Huang,et al.  PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach , 2010, Nucleic Acids Res..

[32]  J. Martinou,et al.  Mitochondria as the central control point of apoptosis. , 2000, Trends in cell biology.