Selective spectral displacement projection for multifrequency MRE

We introduce a new motion encoding concept for the displacement vector in multifrequency magnetic resonance elastography (MRE). Selective spectral displacement projection (SDP)-MRE can be applied to a vibration spectrum composed of three frequencies and exploits the filter condition of MRE for selecting one frequency each per spatial motion encoding direction. The selected components are simultaneously encoded in the phase of the MR signal. Therefore, the total MR phase is represented by a sum of phase portions, each corresponding to a distinct spatial projection and vibration frequency. The individual components can be obtained by applying a Fourier-transform to the temporally resolved phase images. SDP-MRE reduces the number of temporally resolved MRE experiments for data acquisition by a factor of 3, while providing similar wave images as found using conventional monofrequency MRE.

[1]  Carl-Fredrik Westin,et al.  Local multiscale frequency and bandwidth estimation , 1994, Proceedings of 1st International Conference on Image Processing.

[2]  A. Manduca,et al.  Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. , 1995, Science.

[3]  D B Plewes,et al.  Visualizing tissue compliance with MR imaging , 1995, Journal of magnetic resonance imaging : JMRI.

[4]  R. Sinkus,et al.  High-resolution tensor MR elastography for breast tumour detection. , 2000, Physics in medicine and biology.

[5]  J. F. Greenleaf,et al.  Magnetic resonance elastography: Non-invasive mapping of tissue elasticity , 2001, Medical Image Anal..

[6]  Wen-Chun Yeh,et al.  Elastic modulus measurements of human liver and correlation with pathology. , 2002, Ultrasound in medicine & biology.

[7]  Takeo Ishigaki,et al.  Regional ADC values of the normal brain: differences due to age, gender, and laterality , 2002, European Radiology.

[8]  J. Bernarding,et al.  Magnetic resonance elastography and diffusion-weighted imaging of the sol/gel phase transition in agarose. , 2004, Journal of magnetic resonance.

[9]  Abbas Samani,et al.  Observation of nonlinear shear wave propagation using magnetic resonance elastography , 2004, Magnetic resonance in medicine.

[10]  Richard L. Magin,et al.  Microscopic magnetic resonance elastography (μMRE) , 2005 .

[11]  Mickael Tanter,et al.  Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. , 2005, Magnetic resonance imaging.

[12]  Dieter Klatt,et al.  In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography , 2006, Investigative radiology.

[13]  Richard L Ehman,et al.  Determination of thigh muscle stiffness using magnetic resonance elastography , 2006, Journal of magnetic resonance imaging : JMRI.

[14]  Dieter Klatt,et al.  Fractional encoding of harmonic motions in MR elastography , 2007, Magnetic resonance in medicine.

[15]  A. Manduca,et al.  Assessment of hepatic fibrosis with magnetic resonance elastography. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[16]  P. Asbach,et al.  Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity , 2007, Physics in medicine and biology.

[17]  C. Ganter,et al.  Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique , 2008, European Radiology.

[18]  Armando Manduca,et al.  Quantitative assessment of hepatic fibrosis in an animal model with magnetic resonance elastography , 2007, Magnetic resonance in medicine.

[19]  B. V. Van Beers,et al.  MR elastography. , 2008, Gastroenterologie clinique et biologique.

[20]  Dieter Klatt,et al.  Non‐invasive measurement of brain viscoelasticity using magnetic resonance elastography , 2008, NMR in biomedicine.

[21]  Dieter Klatt,et al.  The impact of aging and gender on brain viscoelasticity , 2009, NeuroImage.

[22]  Abbas Samani,et al.  MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations , 2009, Magnetic resonance in medicine.

[23]  Frauke Zipp,et al.  MR-elastography reveals degradation of tissue integrity in multiple sclerosis , 2010, NeuroImage.

[24]  John B Weaver,et al.  Contrast detection in fluid-saturated media with magnetic resonance poroelastography. , 2010, Medical physics.

[25]  Dieter Klatt,et al.  Viscoelasticity-based MR elastography of skeletal muscle , 2010, Physics in medicine and biology.

[26]  K D Paulsen,et al.  Time-harmonic magnetic resonance elastography of the normal feline brain. , 2010, Journal of biomechanics.

[27]  B. Hamm,et al.  Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography. , 2010, Radiology.

[28]  Dieter Klatt,et al.  Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus , 2012, Neuroradiology.

[29]  C. Jack,et al.  Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography , 2011, Journal of magnetic resonance imaging : JMRI.

[30]  Dieter Klatt,et al.  Wide-range dynamic magnetic resonance elastography. , 2011, Journal of biomechanics.

[31]  P V Bayly,et al.  Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography , 2011, Physics in Medicine and Biology.

[32]  R. Sinkus,et al.  Viscoelastic properties of human cerebellum using magnetic resonance elastography. , 2011, Journal of biomechanics.

[33]  Jürgen Braun,et al.  Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis , 2012, NeuroImage: Clinical.

[34]  Ralph Sinkus,et al.  Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography , 2012, Proceedings of the National Academy of Sciences.

[35]  Jürgen Braun,et al.  Multifrequency inversion in magnetic resonance elastography , 2012, Physics in medicine and biology.

[36]  Dieter Klatt,et al.  In vivo measurement of volumetric strain in the human brain induced by arterial pulsation and harmonic waves , 2013, Magnetic resonance in medicine.

[37]  R. Buxton The physics of functional magnetic resonance imaging (fMRI) , 2013, Reports on progress in physics. Physical Society.

[38]  Thomas J Royston,et al.  Wideband MR elastography for viscoelasticity model identification , 2013, Magnetic resonance in medicine.

[39]  P V Bayly,et al.  Viscoelastic properties of the ferret brain measured in vivo at multiple frequencies by magnetic resonance elastography. , 2013, Journal of Biomechanics.