Wound healing around endosseous implants in experimental diabetes.

Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.

[1]  R. Weiss,et al.  Abnormalities in the Biosynthesis of Cartilage and Bone Proteoglycans in Experimental Diabetes , 1981, Diabetes.

[2]  J. Baynes Role of Oxidative Stress in Development of Complications in Diabetes , 1991, Diabetes.

[3]  M Nevins,et al.  The successful application of osseointegrated implants to the posterior jaw: a long-term retrospective study. , 1993, The International journal of oral & maxillofacial implants.

[4]  E. Canalis,et al.  Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria. , 1980, The Journal of clinical investigation.

[5]  J. Ketelslegers,et al.  Nutritional regulation of the insulin-like growth factors. , 1994, Endocrine reviews.

[6]  D. Cochran,et al.  Attachment and Growth of Periodontal Cells on Smooth and Rough Titanium. , 1994, The International journal of oral & maxillofacial implants.

[7]  T Jemt,et al.  Osseointegrated implants in the treatment of partially edentulous patients: a preliminary study on 876 consecutively placed fixtures. , 1989, The International journal of oral & maxillofacial implants.

[8]  S. Lynch,et al.  Non-coordinate Control of Bone Formation Displayed by Growth Factor Combinations with IGF-I , 1997, Journal of dental research.

[9]  S. Teitelbaum,et al.  The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat. , 1981, The Journal of laboratory and clinical medicine.

[10]  J. Dequeker,et al.  Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover and decreased osteocalcin synthesis. , 1989, Endocrinology.

[11]  C. Maniatopoulos,et al.  An improved method for preparing histological sections of metallic implants. , 1986, The International journal of oral & maxillofacial implants.

[12]  R. Spanheimer Direct inhibition of collagen production in vitro by diabetic rat serum. , 1988, Metabolism: clinical and experimental.

[13]  S. Chakrabarti,et al.  Bone mineral metabolism in experimental diabetes mellitus: osteocalcin as a measure of bone remodeling. , 1988, Endocrinology.

[14]  W. Goodman,et al.  Diminished Bone Formation in Experimental Diabetes: Relationship to Osteoid Maturation and Mineralization , 1984, Diabetes.

[15]  V. Monnier,et al.  Accelerated age-related browning of human collagen in diabetes mellitus. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Cerami,et al.  Nonenzymatic glycosylation: role in the pathogenesis of diabetic complications. , 1986, Clinical chemistry.

[17]  E. Ford,et al.  Wound collagenase activity correlates directly with collagen glycosylation in diabetic rats. , 1990, Journal of pediatric surgery.

[18]  D Buser,et al.  The treatment of partially edentulous patients with ITI hollow-screw implants: presurgical evaluation and surgical procedures. , 1990, The International journal of oral & maxillofacial implants.

[19]  H. Imura,et al.  Circulating Levels and Bone Contents of Bone γ-Carboxyglutamic Acid-Containing Protein Are Decreased in Streptozocin-Induced Diabetes: Possible Marker for Diabetic Osteopenia , 1988, Diabetes.

[20]  K. Donath,et al.  A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. , 1982, Journal of oral pathology.

[21]  N. Rakieten Studies on the diabetogenic action of streptozotocin , 1963 .

[22]  D. Steenberghe,et al.  Ten-year survival rates of fixed prostheses on four or six implants ad modum Brånemark in full edentulism. , 1995, Clinical oral implants research.

[23]  H. M. Lee,et al.  Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. , 1983, Journal of periodontal research.

[24]  Y. Zou,et al.  Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. , 1994, The Journal of biological chemistry.

[25]  D. Buser,et al.  Tissue integration of one-stage ITI implants: 3-year results of a longitudinal study with Hollow-Cylinder and Hollow-Screw implants. , 1991, The International journal of oral & maxillofacial implants.

[26]  R. Bucala,et al.  Lipid advanced glycosylation: pathway for lipid oxidation in vivo. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Cerami,et al.  Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. , 1988, The New England journal of medicine.

[28]  J. Verhaeghe,et al.  Bone mineral homeostasis in spontaneously diabetic BB rats. I. Abnormal vitamin D metabolism and impaired active intestinal calcium absorption. , 1989, Endocrinology.

[29]  R. Puche,et al.  Growth and development of bone mass in untreated alloxan diabetic rats. Effects of collagen glycosylation and parathyroid activity on bone turnover. , 1993, Bone and mineral.

[30]  M. Brownlee,et al.  Glycation Products and the Pathogenesis of Diabetic Complications , 1992, Diabetes Care.

[31]  L. Golub,et al.  Diabetes increases collagenase activity in extracts of rat gingiva and skin. , 1983, Journal of periodontal research.

[32]  P I Brånemark,et al.  A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. , 1981, International journal of oral surgery.