Neuroblastoma in a child with Wiedemann-Beckwith syndrome.

We report on a patient with Wiedemann-Beckwith syndrome (WBS) who developed abdominal neuroblastoma. Although WBS patients are known to have a higher incidence of embryonal tumors, this is only the 4th known case of neuroblastoma associated with this syndrome. Chromosomes on peripheral lymphocytes and tumor cells were normal. Children with WBS should be screened for a variety of embryonal neoplasms, not only Wilms tumor.

[1]  J. Costantino,et al.  Flow cytometric DNA analysis of Neuroblastoma and Ganglioneuroma. A 10‐year retrospective study , 1988, Cancer.

[2]  K. Bove.  Pathology of selected abdominal masses in children. , 1988, Seminars in roentgenology.

[3]  N. Hayward,et al.  Generation of homozygosity at the c-Ha-ras-1 locus on chromosome 11p in an adrenal adenoma from an adult with Wiedemann-Beckwith syndrome. , 1988, Cancer genetics and cytogenetics.

[4]  A. Geiser,et al.  Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression. , 1987, Science.

[5]  O. Haas,et al.  Constitutional interstitial deletion of 11p11 and pericentric inversion of chromosome 9 in a patient with Wiedemann-Beckwith syndrome and hepatoblastoma. , 1986, Cancer genetics and cytogenetics.

[6]  N. Copeland,et al.  Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism , 1985, Nature.

[7]  H. B. Marsden,et al.  Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. , 1984, Journal of the National Cancer Institute.

[8]  S. Pueschel,et al.  Chromosome 11 and Beckwith-Wiedemann syndrome. , 1984, The Journal of pediatrics.

[9]  A. Garbes,et al.  Neuroblastoma associated with beckwith‐wiedemann syndrome , 2006, Cancer.

[10]  S. Patil,et al.  Abnormality of chromosome 11 in patients with features of Beckwith-Wiedemann syndrome. , 1983, The Journal of pediatrics.

[11]  F. Gonzalez-crussi,et al.  Complete and incomplete forms of Beckwith-Wiedemann syndrome: their oncogenic potential. , 1980, The Journal of pediatrics.

[12]  Bove Ke,et al.  The nephroblastomatosis complex and its relationship to Wilms' tumor: a clinicopathologic treatise. , 1976 .

[13]  W. Gooch,et al.  Neoplasms associated with the Beckwith-Wiedemann syndrome. , 1976, Perspectives in pediatric pathology.

[14]  A. Knudson,et al.  Mutation and cancer: neuroblastoma and pheochromocytoma. , 1972, American journal of human genetics.

[15]  J. Beckwith.  Macroglossia, omphalocele, adrenal cytomegaly, gigantism, and hyperplastic visceromegaly , 1969 .

[16]  G. Vawter,et al.  Second primary neoplasms in children. , 1968, The American journal of roentgenology, radium therapy, and nuclear medicine.

[17]  D. Ab.  Pathology of tumors , 1965 .

[18]  J. Fraumeni,et al.  ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS. , 1964, The New England journal of medicine.

[19]  Beckwith Jb,et al.  IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS. , 1963 .

[20]  H. Riedel.  Adrenogenital syndrome in a male child due to adrenocortical tumor; report of case with hemihypertrophy and subsequent development of embryoma (Wilms' tumor). , 1952, Pediatrics.

[21]  D. Grayzel,et al.  Mixed tumor of the liver; report of a case with a review of the literature. , 1951, A.M.A. American journal of diseases of children.