Wearable sensors and devices for real-time cardiovascular disease monitoring

Summary Cardiovascular disease (CVD) is a major global health problem. Living with diseases like CVD often requires long-term monitoring, for which flexible and conformable sensors are employed. The developments in materials, devices, integrated electronic systems, the Internet of Things (IoT), and edge computing enable real-time and convenient measurement and detection of signals. Herein, we review the latest developments in the surveillance of various physiological signals of flexible sensors for CVD. First, a variety of signals that can monitor CVD are summarized. Then, the different mechanisms and principles of monitoring pulse signals, as well as the flexible sensor monitoring of electrocardiogram (ECG), phonocardiogram (PCG), seismocardiogram/ballistocardiogram (SCG/BCG), and apexcardiogram (ACG) signals are discussed. Finally, future research directions are proposed based on the current research landscape.

[1]  D. Mandal,et al.  Natural Sugar-Assisted, Chemically Reinforced, Highly Durable Piezoorganic Nanogenerator with Superior Power Density for Self-Powered Wearable Electronics. , 2018, ACS applied materials & interfaces.

[2]  B. Lu,et al.  High-Performance Piezoelectric Nanogenerators with Imprinted P(VDF-TrFE)/BaTiO3 Nanocomposite Micropillars for Self-Powered Flexible Sensors. , 2017, Small.

[3]  Tong Lin,et al.  Unexpectedly high piezoelectricity of electrospun polyacrylonitrile nanofiber membranes , 2019, Nano Energy.

[4]  T. Someya,et al.  All-nanofiber–based, ultrasensitive, gas-permeable mechanoacoustic sensors for continuous long-term heart monitoring , 2020, Proceedings of the National Academy of Sciences.

[5]  Xiaomin Ren,et al.  A facile, precise radial artery pulse sensor based on stretchable graphene-coated fiber , 2017 .

[6]  Xin Jiang,et al.  A Wearable and Highly Sensitive Graphene Strain Sensor for Precise Home-Based Pulse Wave Monitoring. , 2017, ACS sensors.

[7]  Nanshu Lu,et al.  Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics , 2019, Advanced Functional Materials.

[8]  M. O'Rourke,et al.  Pulse wave analysis. , 1996, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[9]  Zhong Lin Wang,et al.  Ultra-Comfortable Hierarchical Nano-Network for Highly Sensitive Pressure Sensor. , 2020, ACS nano.

[10]  G. Shan,et al.  A highly sensitive piezoresistive sensor based on MXenes and polyvinyl butyral with a wide detection limit and low power consumption. , 2020, Nanoscale.

[11]  Kasper Sørensen,et al.  Definition of Fiducial Points in the Normal Seismocardiogram , 2018, Scientific Reports.

[12]  Liqun Zhang,et al.  Wearable, Healable, and Adhesive Epidermal Sensors Assembled from Mussel‐Inspired Conductive Hybrid Hydrogel Framework , 2017 .

[13]  A. O. Bicen,et al.  Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients , 2018, Circulation. Heart failure.

[14]  James J S Norton,et al.  Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces , 2016, Science Advances.

[15]  Xue Feng,et al.  Fabrication of highly pressure-sensitive, hydrophobic, and flexible 3D carbon nanofiber networks by electrospinning for human physiological signal monitoring. , 2019, Nanoscale.

[16]  Taemin Lee,et al.  Ultra-sensitive Pressure sensor based on guided straight mechanical cracks , 2017, Scientific Reports.

[17]  E. O. Polat,et al.  Flexible graphene photodetectors for wearable fitness monitoring , 2019, Science Advances.

[18]  Puchuan Tan,et al.  Self-powered wearable electronics , 2020, Wearable Technologies.

[19]  M. Serpe,et al.  Microgel‐Based Devices as Wearable Capacitive Electronic Skins for Monitoring Cardiovascular Risks , 2019, Advanced Materials Technologies.

[20]  Qiu Jiang,et al.  MXenes stretch hydrogel sensor performance to new limits , 2018, Science Advances.

[21]  Hui-li Shao,et al.  Pulse-driven bio-triboelectric nanogenerator based on silk nanoribbons , 2020 .

[22]  G. Shen,et al.  3D Dielectric Layer Enabled Highly Sensitive Capacitive Pressure Sensors for Wearable Electronics. , 2020, ACS applied materials & interfaces.

[23]  Weidong Wang,et al.  Design and Implementation of T-type MEMS heart sound sensor , 2019, Sensors and Actuators A: Physical.

[24]  Yang Zou,et al.  Self‐Powered Pulse Sensor for Antidiastole of Cardiovascular Disease , 2017, Advanced materials.

[25]  Kouhyar Tavakolian,et al.  Ballistocardiography and Seismocardiography: A Review of Recent Advances , 2015, IEEE Journal of Biomedical and Health Informatics.

[26]  Gokul Swamy,et al.  Calculation of Forward and Backward Arterial Waves by Analysis of Two Pressure Waveforms , 2010, IEEE Transactions on Biomedical Engineering.

[27]  Xiaomeng Liu,et al.  Bioinspired and bristled microparticles for ultrasensitive pressure and strain sensors , 2018, Nature Communications.

[28]  Deming Liu,et al.  Diaphragm‐based optical fiber sensor for pulse wave monitoring and cardiovascular diseases diagnosis , 2019, Journal of biophotonics.

[29]  Takao Someya,et al.  Self‐Adhesive and Ultra‐Conformable, Sub‐300 nm Dry Thin‐Film Electrodes for Surface Monitoring of Biopotentials , 2018, Advanced Functional Materials.

[30]  Zhuo Liu,et al.  A flexible self-arched biosensor based on combination of piezoelectric and triboelectric effects , 2020 .

[31]  Ja Hoon Koo,et al.  Highly Skin‐Conformal Microhairy Sensor for Pulse Signal Amplification , 2014, Advanced materials.

[32]  P. Levkin,et al.  Facile Approach to Conductive Polymer Microelectrodes for Flexible Electronics. , 2021, ACS applied materials & interfaces.

[33]  Mingyu Zhu,et al.  Graphene Oxide‐Templated Conductive and Redox‐Active Nanosheets Incorporated Hydrogels for Adhesive Bioelectronics , 2019, Advanced Functional Materials.

[34]  ZhangYuanfeng,et al.  Highly Sensitive Flexible Printed Accelerometer System for Monitoring Vital Signs , 2014 .

[35]  Puchuan Tan,et al.  Research progress of self-powered flexible biomedical sensors , 2020 .

[36]  Yu-Chan Kim,et al.  Highly Conformable, Transparent Electrodes for Epidermal Electronics. , 2018, Nano letters.

[37]  Lin Jia,et al.  Epidermal photonic devices for quantitative imaging of temperature and thermal transport characteristics of the skin , 2014, Nature Communications.

[38]  Zhong Lin Wang,et al.  Flexible triboelectric generator , 2012 .

[39]  J. Park,et al.  Wearable Capacitive Pressure Sensor Based on MXene Composite Nanofibrous Scaffolds for Reliable Human Physiological Signal Acquisition. , 2020, ACS applied materials & interfaces.

[40]  Aydogan Ozcan,et al.  Wearable and Implantable Sensors for Biomedical Applications. , 2018, Annual review of analytical chemistry.

[41]  Joo Chuan Yeo,et al.  Flexible Wearable Sensors for Cardiovascular Health Monitoring , 2021, Advanced healthcare materials.

[42]  Arjang Hassibi,et al.  CMOS biochips for hypothesis-driven DNA analysis , 2014, 2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings.

[43]  Jun Fu,et al.  Ultrastretchable Strain Sensors and Arrays with High Sensitivity and Linearity Based on Super Tough Conductive Hydrogels , 2018, Chemistry of Materials.

[44]  Mahmoud Al Ahmad,et al.  Simultaneous piezoelectric noninvasive detection of multiple vital signs , 2020, Scientific Reports.

[45]  Zhongze Gu,et al.  Multifunctional Wearable Sensing Devices Based on Functionalized Graphene Films for Simultaneous Monitoring of Physiological Signals and Volatile Organic Compound Biomarkers. , 2018, ACS applied materials & interfaces.

[46]  Hoi-Jun Yoo,et al.  Toward all-day wearable health monitoring: An ultralow-power, reflective organic pulse oximetry sensing patch , 2018, Science Advances.

[47]  Taeghwan Hyeon,et al.  Fully Stretchable Optoelectronic Sensors Based on Colloidal Quantum Dots for Sensing Photoplethysmographic Signals. , 2017, ACS nano.

[48]  Weidong Wang,et al.  A bat-shape piezoresistor electronic stethoscope based on MEMS technology , 2019 .

[49]  Yi Yang,et al.  Epidermis Microstructure Inspired Graphene Pressure Sensor with Random Distributed Spinosum for High Sensitivity and Large Linearity. , 2018, ACS nano.

[50]  Ying Chen,et al.  Flexible inorganic bioelectronics , 2020, npj Flexible Electronics.

[51]  Longlong Chen,et al.  Enhanced Flexible Piezoelectric Sensor by the Integration of P(VDF-TrFE)/AgNWs Film With a-IGZO TFT , 2019, IEEE Electron Device Letters.

[52]  Liming Miao,et al.  Skin Inspired Humidity and Pressure Sensor with Wrinkle-on-Sponge Structure. , 2019, ACS applied materials & interfaces.

[53]  Mian Li,et al.  3D hybrid porous Mxene-sponge network and its application in piezoresistive sensor , 2018, Nano Energy.

[54]  J. Ryou,et al.  High Durable, Biocompatible, and Flexible Piezoelectric Pulse Sensor Using Single‐Crystalline III‐N Thin Film , 2019, Advanced Functional Materials.

[55]  L Dolezal,et al.  Parameters describing the pulse wave. , 2009, Physiological research.

[56]  Liwei Lin,et al.  Human Pulse Diagnosis for Medical Assessments Using a Wearable Piezoelectret Sensing System , 2018, Advanced Functional Materials.

[57]  Quankang Wang,et al.  A Bioinspired Mineral Hydrogel as a Self‐Healable, Mechanically Adaptable Ionic Skin for Highly Sensitive Pressure Sensing , 2017, Advanced materials.

[58]  Pei Huang,et al.  Spider-Inspired Ultra-Sensitive Flexible Vibration Sensor for Multifunctional Sensing. , 2020, ACS applied materials & interfaces.

[59]  P. Antunes,et al.  Optical fiber sensors for central arterial pressure monitoring , 2016 .

[60]  Insang You,et al.  Stretchable E‐Skin Apexcardiogram Sensor , 2016, Advanced materials.

[61]  Andres A. Aguirre-Pablo,et al.  Recyclable Nonfunctionalized Paper‐Based Ultralow‐Cost Wearable Health Monitoring System , 2017 .

[62]  Guang-Zhong Yang,et al.  From Wearable Sensors to Smart Implants-–Toward Pervasive and Personalized Healthcare , 2015, IEEE Transactions on Biomedical Engineering.

[63]  Canhui Lu,et al.  Protein Inspired Self-Healable Ti3C2 MXenes/Rubber-Based Supramolecular Elastomer for Intelligent Sensing. , 2020, ACS nano.

[64]  Yang Sun,et al.  Lowering Internal Friction of 0D–1D–2D Ternary Nanocomposite‐Based Strain Sensor by Fullerene to Boost the Sensing Performance , 2018 .

[65]  Yonggang Huang,et al.  Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow , 2015, Science Advances.

[66]  Gary F Mitchell Triangulating the peaks of arterial pressure. , 2006, Hypertension.

[67]  Jing Li,et al.  Recent progress in flexible pressure sensor arrays: from design to applications , 2018 .

[68]  Jiajie Liang,et al.  Bioinspired Ultrasensitive and Stretchable MXene-Based Strain Sensor via Nacre-Mimetic Microscale "Brick-and-Mortar" Architecture. , 2019, ACS nano.

[69]  Wei‐Ssu Liao,et al.  Multilayered Ag NP-PEDOT-Paper Composite Device for Human-Machine Interfacing. , 2019, ACS applied materials & interfaces.

[70]  A. Struthers,et al.  Pulse wave analysis and pulse wave velocity: a critical review of their strengths and weaknesses , 2003, Journal of hypertension.

[71]  Xuewen Wang,et al.  Silk‐Molded Flexible, Ultrasensitive, and Highly Stable Electronic Skin for Monitoring Human Physiological Signals , 2014, Advanced materials.

[72]  Jinqing Wang,et al.  Graphene-based cellular materials with extremely low density and high pressure sensitivity based on self-assembled graphene oxide liquid crystals , 2018 .

[73]  Yinji Ma,et al.  Ultralow-Cost, Highly Sensitive, and Flexible Pressure Sensors Based on Carbon Black and Airlaid Paper for Wearable Electronics. , 2019, ACS applied materials & interfaces.

[74]  W. Wen,et al.  Synergistic Optimization towards the Sensitivity and Linearity of Flexible Pressure Sensor via Double Conductive Layer and Porous Micro-dome Array. , 2020, ACS applied materials & interfaces.

[75]  Di Liu,et al.  A breathable, biodegradable, antibacterial, and self-powered electronic skin based on all-nanofiber triboelectric nanogenerators , 2020, Science Advances.

[76]  Chang Kyu Jeong,et al.  Self‐Powered Real‐Time Arterial Pulse Monitoring Using Ultrathin Epidermal Piezoelectric Sensors , 2017, Advanced materials.

[77]  Nan Guo,et al.  Design of the MEMS Piezoresistive Electronic Heart Sound Sensor , 2016, Sensors.

[78]  Qifa Zhou,et al.  Monitoring of the central blood pressure waveform via a conformal ultrasonic device , 2018, Nature Biomedical Engineering.

[79]  Ricard Delgado-Gonzalo,et al.  The Handbook of Cuffless Blood Pressure Monitoring: A Practical Guide for Clinicians, Researchers, and Engineers , 2019 .

[80]  Zisheng Xu,et al.  Hierarchical elastomer tuned self-powered pressure sensor for wearable multifunctional cardiovascular electronics , 2020 .

[81]  Smita Mohanty,et al.  Advances in Piezoelectric Polymer Composites for Energy Harvesting Applications: A Systematic Review , 2018, Macromolecular Materials and Engineering.

[82]  Yahong Zhou,et al.  A Tough and Self-Powered Hydrogel for Artificial Skin , 2019 .

[83]  Jinhyoung Park,et al.  A Highly Sensitive and Flexible Capacitive Pressure Sensor Based on a Porous Three-Dimensional PDMS/Microsphere Composite , 2020, Polymers.

[84]  Geng Yang,et al.  Non-Invasive Flexible and Stretchable Wearable Sensors With Nano-Based Enhancement for Chronic Disease Care , 2019, IEEE Reviews in Biomedical Engineering.

[85]  Yang Zou,et al.  Recent progress in human body energy harvesting for smart bioelectronic system , 2021 .

[86]  Jonghwa Park,et al.  Fingertip skin–inspired microstructured ferroelectric skins discriminate static/dynamic pressure and temperature stimuli , 2015, Science Advances.

[87]  Sanat S Bhole,et al.  Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin , 2014, Science.

[88]  Haiying Zhang,et al.  A novel angle extremum maximum method for recognition of pulse wave feature points , 2020, Comput. Methods Programs Biomed..

[89]  Sungwoo Chun,et al.  Conductive and Stretchable Adhesive Electronics with Miniaturized Octopus‐Like Suckers against Dry/Wet Skin for Biosignal Monitoring , 2018, Advanced Functional Materials.

[90]  R. Zhu,et al.  A Wearable Sensor Using Structured Silver‐Particle Reinforced PDMS for Radial Arterial Pulse Wave Monitoring , 2019, Advanced healthcare materials.

[91]  Zhenan Bao,et al.  Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow , 2019, Nature Biomedical Engineering.

[92]  Swagata Roy,et al.  Biowaste crab shell-extracted chitin nanofiber-based superior piezoelectric nanogenerator , 2018 .

[93]  Samuel Sánchez,et al.  Flexible sensors for biomedical technology. , 2016, Lab on a chip.

[94]  Deji Akinwande,et al.  Graphene Electronic Tattoo Sensors. , 2017, ACS nano.

[95]  Guihua Yu,et al.  A Wearable Transient Pressure Sensor Made with MXene Nanosheets for Sensitive Broad-Range Human-Machine Interfacing. , 2019, Nano letters.

[96]  Jayant Sirohi,et al.  A Chest‐Laminated Ultrathin and Stretchable E‐Tattoo for the Measurement of Electrocardiogram, Seismocardiogram, and Cardiac Time Intervals , 2019, Advanced science.

[97]  Xiaodi Zhang,et al.  Transparent and stretchable triboelectric nanogenerator for self-powered tactile sensing , 2019, Nano Energy.

[98]  S. Mugo,et al.  Graphene Oxide Films Prepared Using Gelatin Nanofibers as Wearable Sensors for Monitoring Cardiovascular Health , 2019, Advanced Materials Technologies.

[99]  Xu Wang,et al.  Ultra-conformal drawn-on-skin electronics for multifunctional motion artifact-free sensing and point-of-care treatment , 2020, Nature Communications.

[100]  Xinran Wang,et al.  A Self‐Healable, Highly Stretchable, and Solution Processable Conductive Polymer Composite for Ultrasensitive Strain and Pressure Sensing , 2018 .

[101]  Jing Liu,et al.  Flexible Organic/Inorganic Hybrid Near‐Infrared Photoplethysmogram Sensor for Cardiovascular Monitoring , 2017, Advanced materials.

[102]  Xiaolong Jia,et al.  A wearable, self-adhesive, long-lastingly moist and healable epidermal sensor assembled from conductive MXene nanocomposites , 2020, Journal of Materials Chemistry C.

[103]  Wei Lu,et al.  A Universal high accuracy wearable pulse monitoring system via high sensitivity and large linearity graphene pressure sensor , 2019, Nano Energy.

[105]  S. Yao,et al.  Gas-Permeable, Ultrathin, Stretchable Epidermal Electronics with Porous Electrodes. , 2020, ACS nano.

[106]  A A Luisada,et al.  Phonocardiography as a monitor of cardiac performance during anesthesia. , 1989, Anesthesia and analgesia.

[107]  Rui Yu,et al.  Meso-Reconstruction of Wool Keratin 3D "Molecular Springs" for Tunable Ultra-Sensitive and Highly Recovery Strain Sensors. , 2020, Small.

[108]  Luying Li,et al.  Bioinspired Micro-Spines for a High-Performance Spray Ti3C2Tx MXene-Based Piezoresistive Sensor. , 2020, ACS nano.

[109]  Zefeng Chen,et al.  Flexible Piezoelectric-Induced Pressure Sensors for Static Measurements Based on Nanowires/Graphene Heterostructures. , 2017, ACS nano.

[110]  Chi Hwan Lee,et al.  Skin-Mountable Biosensors and Therapeutics: A Review. , 2019, Annual review of biomedical engineering.

[111]  Chen Huang,et al.  A Facile Strategy for Fabrication of Flexible, Breathable and Washable Piezoelectric Sensor via Welding of Nanofibers with Multiwalled Carbon Nanotube(MWCNT). , 2019, ACS applied materials & interfaces.

[112]  Shuvo Roy,et al.  A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables , 2016, IEEE Transactions on Biomedical Circuits and Systems.

[113]  Roozbeh Jafari,et al.  Noninvasive Cuffless Blood Pressure Estimation Using Pulse Transit Time and Impedance Plethysmography , 2019, IEEE Transactions on Biomedical Engineering.

[114]  Jae‐Woong Jeong,et al.  Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment , 2019, Advanced materials.

[115]  W. Nichols,et al.  McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles , 1998 .

[116]  Ha Uk Chung,et al.  Skin-Interfaced Biosensors and Pilot Studies for Advanced Wireless Physiological Monitoring in Neonatal and Pediatric Intensive Care Units , 2020, Nature Medicine.

[117]  N. Lee,et al.  Flexible and Stretchable Piezoelectric Sensor with Thickness-Tunable Configuration of Electrospun Nanofiber Mat and Elastomeric Substrates. , 2016, ACS applied materials & interfaces.

[118]  Kang Wang,et al.  Bioinspired Interlocked Structure-Induced High Deformability for Two-Dimensional Titanium Carbide (MXene)/Natural Microcapsule-Based Flexible Pressure Sensors. , 2019, ACS nano.

[119]  Tian-Ling Ren,et al.  Triode-Mimicking Graphene Pressure Sensor with Positive Resistance Variation for Physiology and Motion Monitoring. , 2020, ACS nano.

[120]  J. Saul,et al.  Beat-to-Beat Variations of Heart Rate Reflect Modulation of Cardiac Autonomic Outflow , 1990 .

[121]  Yonggang Huang,et al.  Multifunctional Epidermal Electronics Printed Directly Onto the Skin , 2013, Advanced materials.

[122]  Tuo Ji,et al.  Holistically Engineered Polymer–Polymer and Polymer–Ion Interactions in Biocompatible Polyvinyl Alcohol Blends for High‐Performance Triboelectric Devices in Self‐Powered Wearable Cardiovascular Monitorings , 2020, Advanced materials.

[123]  Yonggang Huang,et al.  Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring , 2014, Nature Communications.

[124]  Firat Güder,et al.  Stretchable Composite Acoustic Transducer for Wearable Monitoring of Vital Signs , 2020, Advanced functional materials.

[125]  Panos Vardas,et al.  European Society of Cardiology: Cardiovascular Disease Statistics 2019. , 2019, European heart journal.

[126]  C. Zhang,et al.  Gas‐Permeable, Multifunctional On‐Skin Electronics Based on Laser‐Induced Porous Graphene and Sugar‐Templated Elastomer Sponges , 2018, Advanced materials.

[127]  Ruya Li,et al.  Imperceptible Epidermal–Iontronic Interface for Wearable Sensing , 2018, Advanced materials.

[128]  Yi Yang,et al.  Multilayer Graphene Epidermal Electronic Skin. , 2018, ACS nano.

[129]  Bingbing Gao,et al.  Core/Shell Piezoelectric Nanofibers with Spatial Self-Orientated β-Phase Nanocrystals for Real-Time Micro-Pressure Monitoring of Cardiovascular Walls. , 2019, ACS nano.

[130]  Boris Murmann,et al.  Skin electronics from scalable fabrication of an intrinsically stretchable transistor array , 2018, Nature.

[131]  Guang Zhu,et al.  Highly conductive, stretchable, and breathable epidermal electrode based on hierarchically interactive nano-network. , 2020, Nanoscale.

[132]  Jun Fu,et al.  Stretchable and tough conductive hydrogels for flexible pressure and strain sensors. , 2020, Journal of materials chemistry. B.

[133]  Dae-Hyeong Kim,et al.  Material‐Based Approaches for the Fabrication of Stretchable Electronics , 2019, Advanced materials.

[134]  Xiaodong Chen,et al.  An On‐Skin Electrode with Anti‐Epidermal‐Surface‐Lipid Function Based on a Zwitterionic Polymer Brush , 2020, Advanced materials.

[135]  Kaushik Parida,et al.  Core-shell nanofiber mats for tactile pressure sensor and nanogenerator applications , 2018 .

[136]  Song Gao,et al.  AAO-Assisted Low-Cost Flexible Capacitive Pressure Sensors Based on Double-Sided Nanopillars by Facile Fabrication Method. , 2019, ACS applied materials & interfaces.

[137]  Yihui Zhang,et al.  Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care , 2019, Science.

[138]  J. Rogers,et al.  A Stretchable Form of Single-Crystal Silicon for High-Performance Electronics on Rubber Substrates , 2006, Science.

[139]  Zhong Lin Wang,et al.  Self-powered cardiovascular electronic devices and systems , 2020, Nature Reviews Cardiology.

[140]  Jing Sun,et al.  Strain Sensors with a High Sensitivity and a Wide Sensing Range Based on a Ti3C2Tx (MXene) Nanoparticle–Nanosheet Hybrid Network , 2019, Advanced Functional Materials.

[141]  Francisco Molina-Lopez,et al.  An integrated self-healable electronic skin system fabricated via dynamic reconstruction of a nanostructured conducting network , 2018, Nature Nanotechnology.

[142]  Jinqing Wang,et al.  Stretchable and self-healable electrical sensors with fingertip-like perception capability for surface texture discerning and biosignal monitoring , 2019, Journal of Materials Chemistry C.