Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression
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N. Seyfried | K. Eggan | Sulagna Dia Ghosh | T. Young-Pearse | P. Srikanth | R. Nehme | Valentina N. Lagomarsino | Tracy L. Young-Pearse | R. Pearse | Meichen Liao | Nicholas Seyfried | Nicholas T. Seyfried
[1] Lindy E. Barrett,et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission , 2018, Cell reports.
[2] A. Takata,et al. Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders , 2018, Human molecular genetics.
[3] T. Young-Pearse,et al. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids , 2018, Translational Psychiatry.
[4] M. Fornage,et al. Whole genome sequence analyses of brain imaging measures in the Framingham Study , 2018, Neurology.
[5] I. Scheffer,et al. De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. , 2017, American journal of human genetics.
[6] Qian Wu,et al. DISC1 Regulates the Proliferation and Migration of Mouse Neural Stem/Progenitor Cells through Pax5, Sox2, Dll1 and Neurog2 , 2017, Front. Cell. Neurosci..
[7] J. C. Love,et al. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability , 2017, Alzheimer's & Dementia.
[8] Ryan L. Collins,et al. Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly , 2018, Cell.
[9] Elise M. Stewart,et al. Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice , 2017, Scientific Reports.
[10] A. Hoischen,et al. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. , 2017, American journal of human genetics.
[11] Ryan L. Collins,et al. Implication of LRRC4C and DPP6 in neurodevelopmental disorders , 2017, American journal of medical genetics. Part A.
[12] Madhav Thambisetty,et al. A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. , 2017, Cell systems.
[13] J. Rothberg,et al. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. , 2016, Cell reports.
[14] Kristen J Brennand,et al. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. , 2016, Methods.
[15] Thomas C. Südhof,et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons , 2016, Science.
[16] Marius Wernig,et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. , 2015, Cell stem cell.
[17] D. Selkoe,et al. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. , 2015, Cell reports.
[18] T. Südhof,et al. Analysis of conditional heterozygous STXBP1 mutations in human neurons. , 2015, The Journal of clinical investigation.
[19] H. Stefánsson,et al. The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia , 2015, The Journal of clinical investigation.
[20] Xiaocheng Lu,et al. Neurogenin 2 enhances the generation of patient-specific induced neuronal cells , 2015, Brain Research.
[21] J. Sebat,et al. Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells , 2015, npj Schizophrenia.
[22] Sang Ki Park,et al. Disrupted-in-schizophrenia 1 (DISC1) Regulates Dysbindin Function by Enhancing Its Stability* , 2015, The Journal of Biological Chemistry.
[23] F. Murakami,et al. Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons , 2015, Development.
[24] Ron Weiss,et al. Highly-efficient Cas9-mediated transcriptional programming , 2014, Nature Methods.
[25] A. Chédotal,et al. Faculty Opinions recommendation of FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. , 2014 .
[26] Jonathan A. Cooper. Molecules and mechanisms that regulate multipolar migration in the intermediate zone , 2014, Front. Cell. Neurosci..
[27] R. Klein,et al. FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development , 2014, Neuron.
[28] Li-Huei Tsai,et al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons , 2014, Molecular Psychiatry.
[29] T. Young-Pearse,et al. Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols , 2014, PloS one.
[30] David W. Nauen,et al. Synaptic dysregulation in a human iPS cell model of mental disorders , 2014, Nature.
[31] E. Weledji,et al. The ubiquitous neural cell adhesion molecule (N-CAM) , 2014, Annals of medicine and surgery.
[32] Seung Woo Jung,et al. Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1 , 2014, Stem cell reports.
[33] D. Selkoe,et al. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. , 2014, Human molecular genetics.
[34] C. Abbott,et al. Dipeptidyl Peptidase 10 (DPP10789): A Voltage Gated Potassium Channel Associated Protein Is Abnormally Expressed in Alzheimer's and Other Neurodegenerative Diseases , 2014, BioMed research international.
[35] D. Zheng,et al. Heat Shock Alters the Expression of Schizophrenia and Autism Candidate Genes in an Induced Pluripotent Stem Cell Model of the Human Telencephalon , 2014, PloS one.
[36] D. Clair,et al. DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan , 2014, Molecular Psychiatry.
[37] Jiao Jiao,et al. Direct conversion of adipocyte progenitors into functional neurons. , 2013, Cellular reprogramming.
[38] T. Südhof,et al. Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle , 2013, Neuron.
[39] P. Sullivan,et al. Questions about DISC1 as a genetic risk factor for schizophrenia , 2013, Molecular Psychiatry.
[40] T. Südhof,et al. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation , 2013, Proceedings of the National Academy of Sciences.
[41] Christopher M. Vockley,et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors , 2013, Nature Methods.
[42] Morgan L. Maeder,et al. CRISPR RNA-guided activation of endogenous human genes , 2013, Nature Methods.
[43] T. Südhof,et al. Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells , 2013, Neuron.
[44] M. Karayiorgou,et al. A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons , 2013, Molecular and Cellular Neuroscience.
[45] V. Kalscheuer,et al. CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons , 2012, Nature Cell Biology.
[46] G. Miyoshi,et al. Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate , 2012, Neuron.
[47] M. Schartl,et al. Ectopic Expression of Neurogenin 2 Alone is Sufficient to Induce Differentiation of Embryonic Stem Cells into Mature Neurons , 2012, PloS one.
[48] Bradley P. Coe,et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations , 2012, Nature.
[49] Peter Kirwan,et al. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses , 2012, Nature Neuroscience.
[50] Jürgen Bolz,et al. Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons , 2012, The Journal of Neuroscience.
[51] Akira Sawa,et al. Linking neurodevelopmental and synaptic theories of mental illness through DISC1 , 2011, Nature Reviews Neuroscience.
[52] Anil K. Malhotra,et al. Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia , 2011, Neuron.
[53] J. O'Donnell,et al. Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice , 2011, Proceedings of the National Academy of Sciences.
[54] L. Tsai,et al. Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development , 2011, Neuron.
[55] Randy L. Gollub,et al. DISC1 is associated with cortical thickness and neural efficiency , 2011, NeuroImage.
[56] N. Yamamoto,et al. Laminar and areal expression of unc5d and its role in cortical cell survival. , 2011, Cerebral cortex.
[57] V. Tarabykin,et al. FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons , 2011, Neuroscience Research.
[58] K. Nakajima,et al. Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. , 2011, Human molecular genetics.
[59] T. Kennedy,et al. Netrins: versatile extracellular cues with diverse functions , 2011, Development.
[60] J. Roder,et al. Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex , 2011, The Journal of Neuroscience.
[61] D. Glahn,et al. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes , 2011, Molecular Psychiatry.
[62] A. Hayashi‐Takagi,et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex , 2011, Nature.
[63] R. Tanzi,et al. The Genetics of Alzheimer Disease: Back to the Future , 2010, Neuron.
[64] S. Seshadri,et al. Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. , 2010, Biochemical and biophysical research communications.
[65] D. Selkoe,et al. Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development , 2010, The Journal of Neuroscience.
[66] M. Tohyama,et al. DISC1 regulates N-cadherin and β1-integrin expression in neurons , 2010, Molecular Psychiatry.
[67] M. Tohyama,et al. DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth , 2010, Molecular Psychiatry.
[68] M. Götz,et al. Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons , 2010, PLoS biology.
[69] B. Ylstra,et al. Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3) , 2009, Human Genetics.
[70] H. Tabata,et al. The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative Netrin receptor gene Unc5d and is expressed in multipolar migrating cells , 2008, Molecular and Cellular Neuroscience.
[71] Y. Lo,et al. Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia , 2008, Schizophrenia Research.
[72] M. Koga,et al. Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations , 2008, Neuroscience Letters.
[73] P. Arlotta,et al. Neuronal subtype specification in the cerebral cortex , 2007, Nature Reviews Neuroscience.
[74] M. Tohyama,et al. A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth , 2007, Molecular Psychiatry.
[75] F. Dickerson,et al. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. , 2006, Human molecular genetics.
[76] R. Weinberg,et al. NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation , 2006, Nature Neuroscience.
[77] Christopher A. Ross,et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development , 2005, Nature Cell Biology.
[78] L. DeLisi,et al. A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder , 2005, Molecular Psychiatry.
[79] B. Rudy,et al. DPP10 Modulates Kv4-mediated A-type Potassium Channels* , 2005, Journal of Biological Chemistry.
[80] H. Firth,et al. Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome , 2005, European Journal of Human Genetics.
[81] Makoto Takemoto,et al. Identification of the genes that are expressed in the upper layers of the neocortex. , 2004, Cerebral cortex.
[82] A. Gurney,et al. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons , 2003, Nature Neuroscience.
[83] Kazunori Nakajima,et al. Multipolar Migration: The Third Mode of Radial Neuronal Migration in the Developing Cerebral Cortex , 2003, The Journal of Neuroscience.
[84] S. Snyder,et al. Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[85] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[86] T. Yagi,et al. The cadherin-related neuronal receptor family: a novel diversified cadherin family at the synapse , 2001, Neuroscience Research.
[87] D J Porteous,et al. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. , 2001, American journal of human genetics.
[88] V. Tarabykin,et al. Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. , 2001, Development.
[89] Martin S. Taylor,et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. , 2000, Human molecular genetics.
[90] Mu-ming Poo,et al. A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion , 1999, Cell.
[91] H. Coward. Response to Sullivan , 1996 .
[92] D. Clair,et al. Association within a family of a balanced autosomal translocation with major mental illness , 1990, The Lancet.
[93] S. Lipton,et al. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. , 2011, Cell stem cell.
[94] P. Schwartz,et al. Human Pluripotent Stem Cells , 2011, Methods in Molecular Biology.
[95] Jennifer E. Chubb,et al. The DISC locus in psychiatric illness , 2008, Molecular Psychiatry.
[96] Cheng Li,et al. Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.
[97] K Mizuguchi,et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia , 2007, Molecular Psychiatry.
[98] M Tohyama,et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth , 2003, Molecular Psychiatry.
[99] Larry L. Constantine,et al. Back to the future , 2001, CACM.