Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression

[1]  Lindy E. Barrett,et al.  Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission , 2018, Cell reports.

[2]  A. Takata,et al.  Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders , 2018, Human molecular genetics.

[3]  T. Young-Pearse,et al.  Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids , 2018, Translational Psychiatry.

[4]  M. Fornage,et al.  Whole genome sequence analyses of brain imaging measures in the Framingham Study , 2018, Neurology.

[5]  I. Scheffer,et al.  De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. , 2017, American journal of human genetics.

[6]  Qian Wu,et al.  DISC1 Regulates the Proliferation and Migration of Mouse Neural Stem/Progenitor Cells through Pax5, Sox2, Dll1 and Neurog2 , 2017, Front. Cell. Neurosci..

[7]  J. C. Love,et al.  Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability , 2017, Alzheimer's & Dementia.

[8]  Ryan L. Collins,et al.  Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly , 2018, Cell.

[9]  Elise M. Stewart,et al.  Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice , 2017, Scientific Reports.

[10]  A. Hoischen,et al.  Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. , 2017, American journal of human genetics.

[11]  Ryan L. Collins,et al.  Implication of LRRC4C and DPP6 in neurodevelopmental disorders , 2017, American journal of medical genetics. Part A.

[12]  Madhav Thambisetty,et al.  A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. , 2017, Cell systems.

[13]  J. Rothberg,et al.  Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. , 2016, Cell reports.

[14]  Kristen J Brennand,et al.  Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. , 2016, Methods.

[15]  Thomas C. Südhof,et al.  Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons , 2016, Science.

[16]  Marius Wernig,et al.  Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. , 2015, Cell stem cell.

[17]  D. Selkoe,et al.  Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. , 2015, Cell reports.

[18]  T. Südhof,et al.  Analysis of conditional heterozygous STXBP1 mutations in human neurons. , 2015, The Journal of clinical investigation.

[19]  H. Stefánsson,et al.  The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia , 2015, The Journal of clinical investigation.

[20]  Xiaocheng Lu,et al.  Neurogenin 2 enhances the generation of patient-specific induced neuronal cells , 2015, Brain Research.

[21]  J. Sebat,et al.  Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells , 2015, npj Schizophrenia.

[22]  Sang Ki Park,et al.  Disrupted-in-schizophrenia 1 (DISC1) Regulates Dysbindin Function by Enhancing Its Stability* , 2015, The Journal of Biological Chemistry.

[23]  F. Murakami,et al.  Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons , 2015, Development.

[24]  Ron Weiss,et al.  Highly-efficient Cas9-mediated transcriptional programming , 2014, Nature Methods.

[25]  A. Chédotal,et al.  Faculty Opinions recommendation of FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. , 2014 .

[26]  Jonathan A. Cooper Molecules and mechanisms that regulate multipolar migration in the intermediate zone , 2014, Front. Cell. Neurosci..

[27]  R. Klein,et al.  FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development , 2014, Neuron.

[28]  Li-Huei Tsai,et al.  Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons , 2014, Molecular Psychiatry.

[29]  T. Young-Pearse,et al.  Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols , 2014, PloS one.

[30]  David W. Nauen,et al.  Synaptic dysregulation in a human iPS cell model of mental disorders , 2014, Nature.

[31]  E. Weledji,et al.  The ubiquitous neural cell adhesion molecule (N-CAM) , 2014, Annals of medicine and surgery.

[32]  Seung Woo Jung,et al.  Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1 , 2014, Stem cell reports.

[33]  D. Selkoe,et al.  The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. , 2014, Human molecular genetics.

[34]  C. Abbott,et al.  Dipeptidyl Peptidase 10 (DPP10789): A Voltage Gated Potassium Channel Associated Protein Is Abnormally Expressed in Alzheimer's and Other Neurodegenerative Diseases , 2014, BioMed research international.

[35]  D. Zheng,et al.  Heat Shock Alters the Expression of Schizophrenia and Autism Candidate Genes in an Induced Pluripotent Stem Cell Model of the Human Telencephalon , 2014, PloS one.

[36]  D. Clair,et al.  DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan , 2014, Molecular Psychiatry.

[37]  Jiao Jiao,et al.  Direct conversion of adipocyte progenitors into functional neurons. , 2013, Cellular reprogramming.

[38]  T. Südhof,et al.  Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle , 2013, Neuron.

[39]  P. Sullivan,et al.  Questions about DISC1 as a genetic risk factor for schizophrenia , 2013, Molecular Psychiatry.

[40]  T. Südhof,et al.  Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation , 2013, Proceedings of the National Academy of Sciences.

[41]  Christopher M. Vockley,et al.  RNA-guided gene activation by CRISPR-Cas9-based transcription factors , 2013, Nature Methods.

[42]  Morgan L. Maeder,et al.  CRISPR RNA-guided activation of endogenous human genes , 2013, Nature Methods.

[43]  T. Südhof,et al.  Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells , 2013, Neuron.

[44]  M. Karayiorgou,et al.  A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons , 2013, Molecular and Cellular Neuroscience.

[45]  V. Kalscheuer,et al.  CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons , 2012, Nature Cell Biology.

[46]  G. Miyoshi,et al.  Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate , 2012, Neuron.

[47]  M. Schartl,et al.  Ectopic Expression of Neurogenin 2 Alone is Sufficient to Induce Differentiation of Embryonic Stem Cells into Mature Neurons , 2012, PloS one.

[48]  Bradley P. Coe,et al.  Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations , 2012, Nature.

[49]  Peter Kirwan,et al.  Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses , 2012, Nature Neuroscience.

[50]  Jürgen Bolz,et al.  Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons , 2012, The Journal of Neuroscience.

[51]  Akira Sawa,et al.  Linking neurodevelopmental and synaptic theories of mental illness through DISC1 , 2011, Nature Reviews Neuroscience.

[52]  Anil K. Malhotra,et al.  Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia , 2011, Neuron.

[53]  J. O'Donnell,et al.  Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice , 2011, Proceedings of the National Academy of Sciences.

[54]  L. Tsai,et al.  Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development , 2011, Neuron.

[55]  Randy L. Gollub,et al.  DISC1 is associated with cortical thickness and neural efficiency , 2011, NeuroImage.

[56]  N. Yamamoto,et al.  Laminar and areal expression of unc5d and its role in cortical cell survival. , 2011, Cerebral cortex.

[57]  V. Tarabykin,et al.  FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons , 2011, Neuroscience Research.

[58]  K. Nakajima,et al.  Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. , 2011, Human molecular genetics.

[59]  T. Kennedy,et al.  Netrins: versatile extracellular cues with diverse functions , 2011, Development.

[60]  J. Roder,et al.  Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex , 2011, The Journal of Neuroscience.

[61]  D. Glahn,et al.  Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes , 2011, Molecular Psychiatry.

[62]  A. Hayashi‐Takagi,et al.  DISC1-dependent switch from progenitor proliferation to migration in the developing cortex , 2011, Nature.

[63]  R. Tanzi,et al.  The Genetics of Alzheimer Disease: Back to the Future , 2010, Neuron.

[64]  S. Seshadri,et al.  Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. , 2010, Biochemical and biophysical research communications.

[65]  D. Selkoe,et al.  Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development , 2010, The Journal of Neuroscience.

[66]  M. Tohyama,et al.  DISC1 regulates N-cadherin and β1-integrin expression in neurons , 2010, Molecular Psychiatry.

[67]  M. Tohyama,et al.  DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth , 2010, Molecular Psychiatry.

[68]  M. Götz,et al.  Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons , 2010, PLoS biology.

[69]  B. Ylstra,et al.  Analysis of severely affected patients with dihydropyrimidine dehydrogenase deficiency reveals large intragenic rearrangements of DPYD and a de novo interstitial deletion del(1)(p13.3p21.3) , 2009, Human Genetics.

[70]  H. Tabata,et al.  The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative Netrin receptor gene Unc5d and is expressed in multipolar migrating cells , 2008, Molecular and Cellular Neuroscience.

[71]  Y. Lo,et al.  Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia , 2008, Schizophrenia Research.

[72]  M. Koga,et al.  Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations , 2008, Neuroscience Letters.

[73]  P. Arlotta,et al.  Neuronal subtype specification in the cerebral cortex , 2007, Nature Reviews Neuroscience.

[74]  M. Tohyama,et al.  A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth , 2007, Molecular Psychiatry.

[75]  F. Dickerson,et al.  DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. , 2006, Human molecular genetics.

[76]  R. Weinberg,et al.  NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation , 2006, Nature Neuroscience.

[77]  Christopher A. Ross,et al.  A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development , 2005, Nature Cell Biology.

[78]  L. DeLisi,et al.  A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder , 2005, Molecular Psychiatry.

[79]  B. Rudy,et al.  DPP10 Modulates Kv4-mediated A-type Potassium Channels* , 2005, Journal of Biological Chemistry.

[80]  H. Firth,et al.  Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome , 2005, European Journal of Human Genetics.

[81]  Makoto Takemoto,et al.  Identification of the genes that are expressed in the upper layers of the neocortex. , 2004, Cerebral cortex.

[82]  A. Gurney,et al.  The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons , 2003, Nature Neuroscience.

[83]  Kazunori Nakajima,et al.  Multipolar Migration: The Third Mode of Radial Neuronal Migration in the Developing Cerebral Cortex , 2003, The Journal of Neuroscience.

[84]  S. Snyder,et al.  Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[85]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[86]  T. Yagi,et al.  The cadherin-related neuronal receptor family: a novel diversified cadherin family at the synapse , 2001, Neuroscience Research.

[87]  D J Porteous,et al.  Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. , 2001, American journal of human genetics.

[88]  V. Tarabykin,et al.  Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. , 2001, Development.

[89]  Martin S. Taylor,et al.  Disruption of two novel genes by a translocation co-segregating with schizophrenia. , 2000, Human molecular genetics.

[90]  Mu-ming Poo,et al.  A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion , 1999, Cell.

[91]  H. Coward Response to Sullivan , 1996 .

[92]  D. Clair,et al.  Association within a family of a balanced autosomal translocation with major mental illness , 1990, The Lancet.

[93]  S. Lipton,et al.  Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. , 2011, Cell stem cell.

[94]  P. Schwartz,et al.  Human Pluripotent Stem Cells , 2011, Methods in Molecular Biology.

[95]  Jennifer E. Chubb,et al.  The DISC locus in psychiatric illness , 2008, Molecular Psychiatry.

[96]  Cheng Li,et al.  Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.

[97]  K Mizuguchi,et al.  Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia , 2007, Molecular Psychiatry.

[98]  M Tohyama,et al.  Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth , 2003, Molecular Psychiatry.

[99]  Larry L. Constantine,et al.  Back to the future , 2001, CACM.