A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

May E. Montasser | Sara M. Willems | Min A. Jhun | Jeanette S. Andrews | S. Bandinelli | J. Pankow | P. Deloukas | K. Stirrups | E. Boerwinkle | V. Salomaa | M. Perola | J. O’Connell | M. Boehnke | T. Frayling | V. Gudnason | I. Borecki | A. Hingorani | J. Witteman | J. Beilby | L. Palmer | S. Kardia | K. Small | D. Siscovick | G. Willemsen | M. Province | J. Peden | N. Sattar | A. Palotie | E. Ingelsson | K. Mohlke | L. Bonnycastle | M. Erdos | P. Chines | A. Swift | B. Voight | V. Lyssenko | B. Balkau | D. Zélénika | T. Lakka | R. Rauramaa | I. Rudan | D. Boomsma | J. Meigs | L. Bielak | P. Peyser | J. Dupuis | V. Lagou | J. Hottenga | C. Ladenvall | P. Magnusson | A. Jula | I. Prokopenko | J. Lindström | J. Blangero | Y. Böttcher | T. Johnson | N. Amin | C. Hayward | S. Kanoni | I. Kolčić | J. Lahti | O. Polašek | V. Vitart | M. Dimitriou | G. Eiriksdottir | L. Launer | K. Räikkönen | P. Vollenweider | G. Waeber | E. Widén | T. Aspelund | L. Pérusse | J. Luan | A. Stančáková | N. Forouhi | B. Gigante | G. Hallmans | J. Kuusisto | C. Langenberg | K. Leander | N. Bouatia-Naji | P. Meneton | A. Shuldiner | N. Glazer | Y. Aulchenko | R. Strawbridge | W. Kao | E. Rehnberg | S. Lobbens | B. Sennblad | T. Saaristo | D. Shungin | M. Kumari | A. Ruokonen | P. Pramstaller | Guo Li | J. Jukema | C. Duijn | P. Navarro | E. Wheeler | L. Zgaga | D. Waterworth | S. Trompet | C. Bellis | M. Vohl | H. Yaghootkar | E. D. Geus | C. Lecoeur | U. Faire | M. Andrade | O. Hansson | U. Seedorf | O. Carlson | M. Franzosi | L. Rasmussen-Torvik | T. Zemunik | M. Peričić | M. Järvelin | G. Cadby | M. Martínez-Larrad | M. Boban | M. Sabater-Lleal | M. Serrano-Ríos | M. Vikström | Andrew A. Hicks | G. Dedoussis | G. Lathrop | J. Eriksson | Harry Campbell | Joseph Hung | Danijela Budimir | L. Lind | R. Clarke | James F. Wilson | Toby Johnson | I. Ford | A. Tönjes | Peter Kovacs | A. Smith | Daniel R. Barnes | Toshiko Tanaka | Narisu Narisu | T. Harris | Reedik Mägi | A. Goel | Toshiko Tanaka | B. Oostra | J. Perry | M. Morken | Marina Pehlić | F. Collins | Vincent Mooser | M. Kivimäki | Jerome I. Rotter | Markku Laakso | Sarah H. Wild | Peter E. H. Schwarz | Sirkka Keinänen-Kiukaanniemi | Alisa K Manning | Denis Rybin | Josephine M. Egan | Paul W. Franks | A. Hofman | Ruth J. F. Loos | Luigi Ferrucci | Alan F. Wright | Iva Miljkovic | Johannes H. Smit | B.W.J.H. Penninx | A. Palotie | Jennie Hui | N. Smith | Robert A. Scott | Jacques S. Beckmann | Albert V Smith | Hugh Watkins | Eric J. Brunner | A. Jackson | J. Jukema | Sarah H. Wild | Nancy L. Pedersen | Anders Hamsten | Han Chen | Jose C Florez | Yongmei Liu | Ola Hansson | Michael Stumvoll | Yan V. Sun | Ken K Ong | Udo Seedorf | N. Wareham | Ken K. Ong | Matti Uusitupa | Leif C. Groop | Robert Clarke | Lars Lannfelt | David B Savage | Lars Lannfelt | Richa Saxena | V. Mooser | Caroline S. Fox | J. Tuomilehto | P. Froguel | R. Loos | Anders Hamsten | M. McCarthy | A. Uitterlinden | Elodie Eury | Eric J. G. Sijbrands | J. Kaprio | Ching-Ti Liu | Jose C. Florez | David J. Couper | Kenneth M. Rice | J. Tuomilehto | S. Hercberg | Jonna L. Grimsby | P. Salo | Cornelia M. van Duijn | Ping An | Mustafa Atalay | R. Bergman | Claude Bouchard | Arturo Corbató-Anchuelo | Pilar Galan | S. Heath | Paul C. D. Johnson | K. O. Kyvik | M. Marmot | L. Peltonen | Inês Barroso | R. M. Watanabe | Pierre Meneton | L. Groop | C. V. Duijn | Göran Hallmans | Leena Peltonen | Bruna Gigante | Jose C. Florez | John R. B. Perry | J. Lindström | Lars Lind | Inês Barroso | David B. Savage | P. Vollenweider | Jeffrey R. O'Connell | Nicholas L. Smith | G. Waeber | L. Ferrucci | Paul W. Franks | Eleanor Wheeler | Naveed Sattar | V. Gudnason | J. Kaprio | KIRSTEN OHM Kyvik | Sarah H Wild | Eric J Brunner | L. Groop | Erik Ingelsson | Josephine M. Egan | B. Penninx | V. Salomaa | Jonna L. Grimsby | Han Chen | Tosh Tanaka | Arturo Corbató-Anchuelo | Simon Heath | David B. Savage | Dawn M. Waterworth | José Dupuis | M. Province | R. Mägi | Timo A Lakka | Patrik K Magnusson | J. Meigs

[1]  P. Elliott,et al.  Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels , 2011, Circulation.

[2]  W. Rathmann,et al.  Insulin resistance influences the association of adiponectin levels with diabetes incidence in two population-based cohorts: the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 study and the Framingham Offspring Study , 2011, Diabetologia.

[3]  Simon C. Potter,et al.  The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study , 2011, PLoS genetics.

[4]  I. Borecki,et al.  Meta‐analysis of gene‐environment interaction: joint estimation of SNP and SNP × environment regression coefficients , 2011, Genetic epidemiology.

[5]  G. Abecasis,et al.  MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.

[6]  J. Florez,et al.  The genetics of type 2 diabetes: what have we learned from GWAS? , 2010, Annals of the New York Academy of Sciences.

[7]  Yusuke Nakamura,et al.  Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population , 2010, Journal of Human Genetics.

[8]  Inês Barroso,et al.  Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[9]  J. Pankow,et al.  Impact of repeated measures and sample selection on genome‐wide association studies of fasting glucose , 2010, Genetic epidemiology.

[10]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[11]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[12]  Ayellet V. Segrè,et al.  Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.

[13]  C. Gieger,et al.  Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways , 2010, Diabetes.

[14]  U. Ekelund,et al.  Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence , 2010, Diabetes.

[15]  Tanya M. Teslovich,et al.  Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.

[16]  Ayellet V. Segrè,et al.  Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.

[17]  L. Padyukov.  Faculty Opinions recommendation of Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. , 2010 .

[18]  Jake K. Byrnes,et al.  Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls , 2010, Nature.

[19]  Yurii S. Aulchenko,et al.  ProbABEL package for genome-wide association analysis of imputed data , 2010, BMC Bioinformatics.

[20]  Eric Boerwinkle,et al.  A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. , 2010, American journal of human genetics.

[21]  Alex Doney,et al.  Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge , 2010, Nature Genetics.

[22]  P. Elliott,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[23]  Ferdinand von Meyenn,et al.  Regulation of adaptive behaviour during fasting by hypothalamic Foxa2 , 2009, Nature.

[24]  Hilary F Ryder,et al.  Decision Analysis and Cost-effectiveness Analysis. , 2009, Seminars in spine surgery.

[25]  V. Trischitta,et al.  Insulin signaling regulating genes: effect on T2DM and cardiovascular risk , 2009, Nature Reviews Endocrinology.

[26]  M. Mangino,et al.  Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene–obesity interaction , 2009, Diabetologia.

[27]  Marc W. Kirschner,et al.  Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.

[28]  Jean Tichet,et al.  Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia , 2009, Nature Genetics.

[29]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[30]  M. McCarthy,et al.  Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data , 2009, Diabetes.

[31]  P. Ridker,et al.  Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis Among 18 245 Initially Healthy Women From the Women’s Genome Health Study , 2009, Circulation. Cardiovascular genetics.

[32]  T. Hansen,et al.  Common nonsynonymous variants in PCSK1 confer risk of obesity , 2008, Nature Genetics.

[33]  C. Fox,et al.  Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study , 2008, Diabetes.

[34]  Xiao-Hua Zhou,et al.  Statistical Methods for Meta‐Analysis , 2008 .

[35]  J. Florez.  Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes? , 2008, Diabetologia.

[36]  F. Horber,et al.  The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies , 2008, BMC Medical Genetics.

[37]  John D. Storey,et al.  Mapping the Genetic Architecture of Gene Expression in Human Liver , 2008, PLoS biology.

[38]  E. Rampersaud,et al.  Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish , 2007, Diabetes.

[39]  G. Abecasis,et al.  Optimal designs for two‐stage genome‐wide association studies , 2007, Genetic epidemiology.

[40]  N. Sonenberg,et al.  UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells , 2007, Science.

[41]  C. Gieger,et al.  Genomewide association analysis of coronary artery disease. , 2007, The New England journal of medicine.

[42]  P. Donnelly,et al.  A new multipoint method for genome-wide association studies by imputation of genotypes , 2007, Nature Genetics.

[43]  A. Minenna,et al.  Heterogeneous Effect of Peroxisome Proliferator‐activated Receptor γ2 Ala12 Variant on Type 2 Diabetes Risk , 2007, Obesity.

[44]  David M Nathan,et al.  Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. , 2007, The Journal of clinical endocrinology and metabolism.

[45]  T. Hudson,et al.  A genome-wide association study identifies novel risk loci for type 2 diabetes , 2007, Nature.

[46]  Peter Kraft,et al.  Exploiting Gene-Environment Interaction to Detect Genetic Associations , 2007, Human Heredity.

[47]  S. Kahn,et al.  Mechanisms linking obesity to insulin resistance and type 2 diabetes , 2006, Nature.

[48]  P. Scherer,et al.  Adipose tissue-derived factors: impact on health and disease. , 2006, Endocrine reviews.

[49]  G. Abecasis,et al.  Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies , 2006, Nature Genetics.

[50]  S. Hubbard,et al.  Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. , 2005, Molecular cell.

[51]  Alain Favier,et al.  In silico identification and expression of SLC30 family genes: An expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression , 2004, BMC Genomics.

[52]  G. Barish,et al.  PPARs and the complex journey to obesity , 2004, Nature Medicine.

[53]  Alberto Riva,et al.  A SNP-centric database for the investigation of the human genome , 2004, BMC Bioinformatics.

[54]  R. Stein,et al.  Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family. , 2004, The Journal of clinical endocrinology and metabolism.

[55]  J. Klingensmith,et al.  Cordon-bleu is a conserved gene involved in neural tube formation. , 2003, Developmental biology.

[56]  O. Michielin,et al.  Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. , 2003, The Journal of clinical endocrinology and metabolism.

[57]  F. Giorgino,et al.  Two Novel Proteins That Are Linked to Insulin-like Growth Factor (IGF-I) Receptors by the Grb10 Adapter and Modulate IGF-I Signaling* , 2003, Journal of Biological Chemistry.

[58]  J. Lillehaug,et al.  Platelet-derived Growth Factor (PDGF)-C, a PDGF Family Member with a Vascular Endothelial Growth Factor-like Structure* , 2003, The Journal of Biological Chemistry.

[59]  Z. Bloomgarden,et al.  Inflammation and insulin resistance. , 2003, Diabetes care.

[60]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[61]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[62]  S. Henikoff,et al.  Predicting deleterious amino acid substitutions. , 2001, Genome research.

[63]  S. Schurmans,et al.  The lipid phosphatase SHIP2 controls insulin sensitivity , 2001, Nature.

[64]  H. Lodish,et al.  Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles* , 2000, The Journal of Biological Chemistry.

[65]  T. Lange,et al.  Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. , 1998, Science.

[66]  M. White,et al.  The IRS-signalling system: A network of docking proteins that mediate insulin action , 1998, Molecular and Cellular Biochemistry.

[67]  W. Clarke,et al.  Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 , 1997, Nature Genetics.

[68]  T. Sanke,et al.  Human Prohormone Convertase 3 Gene: Exon-Intron Organization and Molecular Scanning for Mutations in Japanese Subjects With NIDDM , 1996, Diabetes.

[69]  R. Roth,et al.  Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Diana B. Petitti,et al.  Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine , 1994 .

[71]  A. Folsom,et al.  The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. , 1989, American journal of epidemiology.

[72]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[73]  Tanya M. Teslovich,et al.  Association analyses of 249 , 796 individuals reveal 18 new loci associated with body mass index , 2012 .

[74]  G. Abecasis,et al.  Genotype imputation. , 2009, Annual review of genomics and human genetics.

[75]  Waterworth,et al.  Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution , 2009 .

[76]  Pardis C Sabeti,et al.  Common deletion polymorphisms in the human genome , 2006, Nature Genetics.

[77]  J. Resau,et al.  ARAP1: a point of convergence for Arf and Rho signaling. , 2002, Molecular cell.

[78]  E S Lander,et al.  The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. , 2000, Nature genetics.

[79]  A. Krainer,et al.  The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. , 1999, Genes & development.

[80]  P. Schofield,et al.  The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. , 1996, Brain research. Molecular brain research.

[81]  Nature Genetics , 1991, Nature.