Anti‐Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

[1]  G. Hager,et al.  DNA binding triggers tetramerization of the glucocorticoid receptor in live cells , 2016, Proceedings of the National Academy of Sciences.

[2]  S. Fuchs,et al.  Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis , 2016, Oncotarget.

[3]  C. Libert,et al.  The glucocorticoid receptor in inflammatory processes: transrepression is not enough , 2015, Biological chemistry.

[4]  Á. Corbí,et al.  CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo , 2015, Journal of leukocyte biology.

[5]  Chenqi Zhao,et al.  LPA Promotes T Cell Recruitment through Synthesis of CXCL13 , 2015, Mediators of inflammation.

[6]  O. Sarig,et al.  Pyoderma gangrenosum, acne and ulcerative colitis in a patient with a novel mutation in the PSTPIP1 gene , 2015, Clinical and experimental dermatology.

[7]  William Stafford Noble,et al.  The MEME Suite , 2015, Nucleic Acids Res..

[8]  J. Stender,et al.  Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities , 2015, Cell.

[9]  Myong-Hee Sung,et al.  DNase footprint signatures are dictated by factor dynamics and DNA sequence. , 2014, Molecular cell.

[10]  Kate B. Cook,et al.  Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity , 2014, Cell.

[11]  Peter Rodgers,et al.  eulerAPE: Drawing Area-Proportional 3-Venn Diagrams Using Ellipses , 2014, PloS one.

[12]  L. Grøntved,et al.  Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor , 2014, PLoS biology.

[13]  Myong-Hee Sung,et al.  Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF-κB Signaling , 2014, Science Signaling.

[14]  M. Sung,et al.  Overlapping Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions , 2013, Nature Structural &Molecular Biology.

[15]  S. Bekiranov,et al.  Measuring Chromatin Interaction Dynamics on the Second Time Scale at Single-Copy Genes , 2013, Science.

[16]  L. Grøntved,et al.  Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level. , 2013, Cancer research.

[17]  Thomas A. Wynn,et al.  Macrophage biology in development, homeostasis and disease , 2013, Nature.

[18]  M. Sung,et al.  Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation , 2013, Genome research.

[19]  Petra C. Schwalie,et al.  Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. , 2013, Molecular cell.

[20]  Nathan C. Sheffield,et al.  The accessible chromatin landscape of the human genome , 2012, Nature.

[21]  David Z. Chen,et al.  Architecture of the human regulatory network derived from ENCODE data , 2012, Nature.

[22]  I. Rogatsky,et al.  Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids , 2012, Proceedings of the National Academy of Sciences.

[23]  Clifford A. Meyer,et al.  Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics , 2012, Genome research.

[24]  R. Ransohoff,et al.  The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood , 2012, The Journal of Immunology.

[25]  R. Pierce,et al.  Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. , 2011, The Journal of clinical investigation.

[26]  H. Stunnenberg,et al.  Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes. , 2011, Genome research.

[27]  Ty C. Voss,et al.  Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism , 2011, Cell.

[28]  Myong-Hee Sung,et al.  Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. , 2011, Molecular cell.

[29]  S. Mandrup,et al.  Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis , 2011, The EMBO journal.

[30]  P. Chambon,et al.  Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor , 2011, Cell.

[31]  J. Stamatoyannopoulos,et al.  Chromatin accessibility pre-determines glucocorticoid receptor binding patterns , 2011, Nature Genetics.

[32]  V. Pascual,et al.  Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review , 2010, Current genomics.

[33]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[34]  J. Ragoussis,et al.  Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. , 2010, Immunity.

[35]  Richard M Myers,et al.  Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. , 2009, Genome research.

[36]  Timothy K Lee,et al.  A Noisy Paracrine Signal Determines the Cellular NF-κB Response to Lipopolysaccharide , 2009, Science Signaling.

[37]  M. Krieger,et al.  Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. , 2009, Blood.

[38]  M. Hickey,et al.  Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation , 2008, Circulation research.

[39]  Chi-Huey Wong,et al.  CLEC5A is critical for dengue-virus-induced lethal disease , 2008, Nature.

[40]  E. Alnemri,et al.  Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. , 2007, Molecular cell.

[41]  J. Brewer,et al.  Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. , 2007, Blood.

[42]  Somasekar Seshagiri,et al.  De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling , 2004, Nature.

[43]  D. Wallach.  Faculty Opinions recommendation of De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. , 2004 .

[44]  D. Kastner,et al.  Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Lovett,et al.  Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. , 2002, Human molecular genetics.

[46]  P. Herrlich,et al.  Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor , 2001, The EMBO journal.

[47]  C. Riccardi,et al.  Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. , 2001, Blood.

[48]  J. Cidlowski,et al.  CBP (CREB Binding Protein) Integrates NF-κB (Nuclear Factor-κB) and Glucocorticoid Receptor Physical Interactions and Antagonism , 2000 .

[49]  Myong-Hee Sung,et al.  Genome-Scale Analysis of Cell-Specific Regulatory Codes Using Nuclear Enzymes , 2016, Statistical Genomics.

[50]  M. Sung,et al.  Quantitative analysis of genome-wide chromatin remodeling. , 2012, Methods in molecular biology.

[51]  J. Cidlowski,et al.  CBP (CREB binding protein) integrates NF-kappaB (nuclear factor-kappaB) and glucocorticoid receptor physical interactions and antagonism. , 2000, Molecular endocrinology.