Hypoxia‐induced Pulmonary Vasoconstriction in Man: Inhibition due to Diethyl Ether and Halothane Anesthesia

Impaired pulmonary gas exchange resulting in arterial hypoxemia is frequently observed in patients during general anesthesia. Recent animal investigations have revealed that pulmonary hypoxia‐induced vasoconstriction (a local mechanism which redistributes pulmonary blood flow from poorly to more amply ventilated regions) is abolished by commonly used inhalation anesthetics. Injectable anesthetics do not have this effect.

[1]  M. K. Sykes,et al.  Reduction of hypoxic pulmonary vasoconstriction in the dog during administration of nitrous oxide. , 1978, British journal of anaesthesia.

[2]  M. K. Sykes,et al.  REDUCTION OF HYPOXIC PULMONARY VASOCONSTRICTION IN THE DOG DURING ADMINISTRATION OF NITROUS OXIDE , 1977 .

[3]  L. Bjertnaes,et al.  Hypoxia‐induced Vasoconstriction in Isolated Perfused Lungs exposed to Injectable or Inhalation Anesthetics , 1977, Acta anaesthesiologica Scandinavica.

[4]  M. K. Sykes,et al.  Reduction of hypoxic pulmonary vasoconstriction during diethyl ether anaesthesia in the dog. , 1977, British journal of anaesthesia.

[5]  M. K. Sykes,et al.  The effects of halothane and ether on the pulmonary circulation in the innervated perfused cat lung. , 1977, British journal of anaesthesia.

[6]  J. Benumof,et al.  General anesthetics and regional hypoxic pulmonary vasoconstriction. , 1977, Anesthesiology.

[7]  R. Ament.  The expanding role of the American Society of Anesthesiologists. , 1976, Anesthesiology.

[8]  D. Craig,et al.  Closing capacity measurement during general anesthesia. , 1976, Anesthesiology.

[9]  J. Benumof,et al.  Cyclic hypoxic pulmonary vasoconstriction induced by concomitant carbon dioxide changes. , 1976, Journal of applied physiology.

[10]  G. Hedenstierna,et al.  Airway Closure and Distribution of Inspired Gas in the Extremely Obese, Breathing Spontaneously and During Anaesthesia with Intermittent Positive Pressure Ventilation , 1976, Acta anaesthesiologica Scandinavica.

[11]  T. Kumazawa,et al.  Myocardial Function and Metabolism in the Conscious Dog and during Halothane Anesthesia , 1976, Anesthesiology.

[12]  J. Bredesen,et al.  Hypoxic pulmonary vasoconstriction: inhibition due to anesthesia. , 1976, Acta physiologica Scandinavica.

[13]  P. Suter,et al.  Shunt, Lung Volume and Perfusion during Short Periods of Ventilation with Oxygen , 1975, Anesthesiology.

[14]  J. Benumof,et al.  Local Effects of Anesthetics on Regional Hypoxic Pulmonary Vasoconstriction , 1975, Anesthesiology.

[15]  J. Benumof,et al.  Blunted hypoxic pulmonary vasoconstriction by increased lung vascular pressures. , 1975, Journal of applied physiology.

[16]  J. Reeves,et al.  Nonsustained pulmonary vasoconstriction during acute hypoxia in anesthetized dogs. , 1975, The American journal of physiology.

[17]  D. H. Will,et al.  Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. , 1975, The American journal of physiology.

[18]  J. Hughes.  Lung gas tensions and active regulation of ventilation/perfusion ratios in health and disease. , 1975, British journal of diseases of the chest.

[19]  A. Froese,et al.  Effects of anesthesia and paralysis on diaphragmatic mechanics in man. , 1974, Anesthesiology.

[20]  M. K. Sykes,et al.  The effects of halothane, trichloroethylene and ether on the hypoxic pressor response and pulmonary vascular resistance in the isolated, perfused cat lung. , 1973, British journal of anaesthesia.

[21]  R. Hickey,et al.  Effects of Halothane Anesthesia on Functional Residual Capacity and Alveolar–Arterial Oxygen Tension Difference , 1973, Anesthesiology.

[22]  B. Kidd,et al.  Time course of pulmonary vascular response to hypoxia in dogs. , 1973, The American journal of physiology.

[23]  K. Wulff,et al.  The regional lung function in the lateral decubitus position during anesthesia and operation. , 1973, Acta anaesthesiologica Scandinavica.

[24]  K. Wulff,et al.  The Regional Lung Function in the Lateral Decubitus Position During Anesthesia and Operation , 1972 .

[25]  M. K. Sykes,et al.  The effect of inhalational anaesthetics on hypoxic pulmonary vasoconstriction and pulmonary vascular resistance in the perfused lungs of the dog and cat. , 1972, British journal of anaesthesia.

[26]  D. Craig,et al.  Airway Closure, Gas Trapping, and the Functional Residual Capacity during Anesthesia , 1972, Anesthesiology.

[27]  J. W. Shaw,et al.  Effect of changes in blood pH on the vascular resistance of the normal and hypoxic cat lung. , 1971, Cardiovascular research.

[28]  H. Don,et al.  The Effects of Anesthesia and 100 Per Cent Oxygen on the Functional Residual Capacity of the Lungs , 1970, Anesthesiology.

[29]  S. Subramanian,et al.  Pulonary edema of high altitude. I. Production of pulmonary edema in animals under conditions of simulated high altitude. , 1969, The American review of respiratory disease.

[30]  H. L. Price,et al.  Pulmonary Hemodynamics during General Anesthesia in Man , 1969, Anesthesiology.

[31]  N. Staub,et al.  Prevention of hypoxic vasoconstriction in cat lung by histamine-releasing agent 48/80. , 1969, Journal of applied physiology.

[32]  A. Hauge.  Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolar PO2. , 1969, Acta physiologica Scandinavica.

[33]  G. R. Kelman,et al.  The influence of cardiac output on arterial oxygenation: a theoretical study. , 1967, British journal of anaesthesia.

[34]  V. Chernick,et al.  Effect of Regional Hypoxia on the Distribution of Pulmonary Blood Flow in Man , 1966, Circulation research.

[35]  T. Lloyd.  Influence of blood pH on hypoxic pulmonary vasoconstriction. , 1966, Journal of applied physiology.

[36]  R. Rokseth.  The effect of altered blood carbon dioxide tension and pH on the human pulmonary circulation. Hyperventilation and infusion studies in patients with heart and lung diseases. , 1966, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[37]  V. Chernick,et al.  Estimation of differential pulmonary blood flow by bronchospirometry and radioisotope scanning during rest and exercise. , 1965, The American review of respiratory disease.

[38]  C. Giuntini,et al.  THE INFLUENCE OF HYDROGEN ION CONCENTRATION AND HYPOXIA ON THE PULMONARY CIRCULATION. , 1964, The Journal of clinical investigation.

[39]  W. S. Fowler,et al.  FUNCTION OF EACH LUNG OF DOGS DURING INTERMITTENT POSITIVE-PRESSURE BREATHING. , 1964, The American journal of physiology.

[40]  M. Buckley,et al.  EFFECTS OF ANESTHETIC AGENTS ON PULMONARY VASCULAR RESISTANCE DURING HYPOXIA. , 1964, Surgical forum.

[41]  J. Vogel,et al.  PULMONARY HYPERTENSION. INDIVIDUAL AND SPECIES VARIABILITY RELATIVE TO VASCULAR REACTIVITY. , 1963, American heart journal.

[42]  K. Fowler,et al.  Effect of alveolar hypoxia on zonal distribution of pulmonary blood flow. , 1963, Journal of applied physiology.

[43]  R. Gamboa,et al.  Pulmonary hypertension in children born and living at high altitudes. , 1963, The American journal of cardiology.

[44]  J. West,et al.  Regional differences in gas exchange in the lung of erect man. , 1962, Journal of applied physiology.

[45]  J. Merriman,et al.  THE EFFECT OF ANAESTHESIA UPON PULMONARY CIRCULATION , 1962, Anesthesia and analgesia.

[46]  J. Nunn.  The distribution of inspired gas during thoracic surgery. , 1961, Annals of the Royal College of Surgeons of England.

[47]  M. Arborelius,et al.  Influence of unilateral hypoxia on blood flow through the lungs in man in lateral position. , 1960, Journal of applied physiology.

[48]  M. Arborelius,et al.  Effect of 'unilateral hypoxia' on pulmonary blood flow distribution in normal subjects. , 1960, Journal of applied physiology.

[49]  J. Whittenberger,et al.  Effects of unilateral hypoxia and hypercapnia on pulmonary blood flow distribution in the dog. , 1957, The American journal of physiology.

[50]  A. Hurtado,et al.  Pulmonary circulation at sea level and at high altitudes. , 1956, Journal of applied physiology.

[51]  C. Hertz.  [The effect of alveolar gas pressure on intrapulmonary blood circulatory distribution in humans]. , 1956, Klinische Wochenschrift.

[52]  W. Blakemore,et al.  The effect of unilateral rebreathing of low oxygen gas mixtures upon the pulmonary blood flow in man. , 1955, Surgical forum.

[53]  W. Newton.  THE INFLUENCE OF POSITIVE PRESSURE BREATHING ON THE CIRCULATION IN MAN By Lars Werkö. Stockholm: Alb. Bonniers Bocktryckeri. 1947. 5¾ × 9. pp. 125, illustrated. Also published as a Supplement to Acta Medica Scandinavica. Price not stated. , 1948, International Journal of Clinical Practice.

[54]  G. Liljestrand,et al.  Observations on the Pulmonary Arterial Blood Pressure in the Cat , 1946 .