论文信息 - The Effects of Ethane-1-Hydroxy-1, 1-Diphosphonate (EHDP) on the Local Calcergy in Rats

The Effects of Ethane-1-Hydroxy-1, 1-Diphosphonate (EHDP) on the Local Calcergy in Rats

The effects of high doses of EHDP on the local Pb-acetate induced calcergy were studied in young female rats. A plaque of hydroxyapatite crystals was produced by local subctaneous injection of a lead acetate dilution. Reactions at injection site of dilution were evaluated by the mean diameter and the dry weight of the calcified wheals. At high doses of EHDP (above 20mg/kg/day), the hydroxyapatite crystal deposition were inhibited significantly.

[1] 江口正雄,et al. Fault of Ossification and Calcification and Angular Deformities of Long Bones in the Mouse Fetuses Caused by High Doses of Ethane-1-Hydroxy-1, 1-Diphosphonate (EHDP) During Pregnancy , 1982 .

[2] M. Rohlin. Whole-body autoradiography of 99Tcm-labelled ethylene-1-hydroxy-1, 1-diphosphonate (EHDP) in young rats. , 1976, Acta radiologica: therapy, physics, biology.