The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane

[1]  P. Vigneri,et al.  AKT Inhibitors: New Weapons in the Fight Against Breast Cancer? , 2021, Frontiers in Pharmacology.

[2]  Susan S. Taylor,et al.  mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif , 2021, Science Signaling.

[3]  E. Jacinto,et al.  Regulation and metabolic functions of mTORC1 and mTORC2. , 2021, Physiological reviews.

[4]  Jian-Ping Cai,et al.  The overexpression of AUF1 in colorectal cancer predicts a poor prognosis and promotes cancer progression by activating ERK and AKT pathways , 2020, Cancer medicine.

[5]  G. Brewer,et al.  IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex , 2020, Nature Communications.

[6]  M. Hall,et al.  Regulation of mTORC2 Signaling , 2020, Genes.

[7]  Xianjun Zhu,et al.  G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity , 2020, Molecular Cancer Research.

[8]  B. Kennedy,et al.  The quest to slow ageing through drug discovery , 2020, Nature Reviews Drug Discovery.

[9]  Ziyan Wang,et al.  Sin1 promotes proliferation and invasion of prostate Cancer cells by modulating mTORC2-AKT and AR signaling cascades. , 2020, Life sciences.

[10]  H. Hou,et al.  The role of RICTOR amplification in targeted therapy and drug resistance , 2020, Molecular Medicine.

[11]  E. Jacinto,et al.  Targeting mTOR and Metabolism in Cancer: Lessons and Innovations , 2019, Cells.

[12]  D. Fingar,et al.  AMPK directly activates mTORC2 to promote cell survival during acute energetic stress , 2019, Science Signaling.

[13]  A. Giordano,et al.  Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation , 2019, Nucleic acids research.

[14]  G. Werlen,et al.  mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation , 2018, The Journal of Biological Chemistry.

[15]  R. Freeman,et al.  mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma , 2017, Oncogene.

[16]  Overexpression of Rictor protein in colorectal cancer is correlated with tumor progression and prognosis. , 2017, Oncology letters.

[17]  Chad J. Creighton,et al.  UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses , 2017, Neoplasia.

[18]  N. Colburn,et al.  Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma , 2017, Oncogene.

[19]  Pascale G. Charest,et al.  Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium , 2017, Journal of Cell Science.

[20]  A. Toker,et al.  AKT/PKB Signaling: Navigating the Network , 2017, Cell.

[21]  David M. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[22]  G. M. Wilson,et al.  AUF1 regulation of coding and noncoding RNA , 2017, Wiley interdisciplinary reviews. RNA.

[23]  D. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[24]  G. Sun,et al.  RICTOR expression in esophageal squamous cell carcinoma and its clinical significance , 2017, Medical Oncology.

[25]  H. Loh,et al.  Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP). , 2017, Gene.

[26]  Peng Guo,et al.  Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer , 2016, Oncotarget.

[27]  Peng Liu,et al.  Upregulation of AUF1 is involved in the proliferation of esophageal squamous cell carcinoma through GCH1. , 2016, International journal of oncology.

[28]  C. Dang,et al.  From Krebs to clinic: glutamine metabolism to cancer therapy , 2016, Nature Reviews Cancer.

[29]  J. Rabinowitz,et al.  mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. , 2016, Molecular cell.

[30]  M. V. Estrada,et al.  Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers. , 2016, Cancer Research.

[31]  M. Hall,et al.  mTORC2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue , 2016, EMBO molecular medicine.

[32]  Sanjay Goel,et al.  RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors. , 2015, Cancer discovery.

[33]  Ruth Nussinov,et al.  Defining the Domain Arrangement of the Mammalian Target of Rapamycin Complex Component Rictor Protein , 2015, J. Comput. Biol..

[34]  S. S. Chauhan,et al.  Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer , 2015, Journal of Translational Medicine.

[35]  J. Malter,et al.  Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1 , 2015, Biomolecules.

[36]  Kotb Abdelmohsen,et al.  PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity , 2014, Nature Communications.

[37]  Adiel Cohen,et al.  Glucose Activates TORC2-Gad8 Protein via Positive Regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) Pathway and Negative Regulation of the Pmk1 Protein-Mitogen-activated Protein Kinase Pathway* , 2014, The Journal of Biological Chemistry.

[38]  Michael N. Hall,et al.  Making new contacts: the mTOR network in metabolism and signalling crosstalk , 2014, Nature Reviews Molecular Cell Biology.

[39]  Chien-hung Chen,et al.  Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism* , 2013, The Journal of Biological Chemistry.

[40]  G. Brewer,et al.  Hsp27 and F-Box Protein β-TrCP Promote Degradation of mRNA Decay Factor AUF1 , 2013, Molecular and Cellular Biology.

[41]  S. Pizzo,et al.  Upregulation of mTORC2 activation by the selective agonist of EPAC, 8‐CPT‐2Me‐cAMP, in prostate cancer cells: Assembly of a multiprotein signaling complex , 2012, Journal of cellular biochemistry.

[42]  V. Zinzalla,et al.  Activation of mTORC2 by Association with the Ribosome , 2011, Cell.

[43]  C. D. Krause,et al.  Chaperone Hsp27 Modulates AUF1 Proteolysis and AU-Rich Element-Mediated mRNA Degradation , 2011, Molecular and Cellular Biology.

[44]  Philippe P Roux,et al.  mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide , 2010, The EMBO journal.

[45]  G. M. Wilson,et al.  Alternatively Expressed Domains of AU-rich Element RNA-binding Protein 1 (AUF1) Regulate RNA-binding Affinity, RNA-induced Protein Oligomerization, and the Local Conformation of Bound RNA Ligands* , 2010, The Journal of Biological Chemistry.

[46]  B. Trojanowicz,et al.  The role of AUF1 in thyroid carcinoma progression. , 2009, Endocrine-related cancer.

[47]  S. Pestka,et al.  AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. , 2008, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[48]  K. Inoki,et al.  Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling , 2008, The EMBO journal.

[49]  A. Newton,et al.  The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C , 2008, The EMBO journal.

[50]  D. V. van Aalten,et al.  Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance , 2008, Molecular and Cellular Biology.

[51]  Joseph Gera,et al.  mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. , 2007, Cancer research.

[52]  Nicole Cloonan,et al.  Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. , 2007, Cellular signalling.

[53]  G. Brewer,et al.  Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation , 2007, Nature Structural &Molecular Biology.

[54]  J. Qin,et al.  SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.

[55]  R. Hresko,et al.  mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes* , 2005, Journal of Biological Chemistry.

[56]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[57]  R. Schneider,et al.  Selective Degradation of AU-Rich mRNAs Promoted by the p37 AUF1 Protein Isoform , 2003, Molecular and Cellular Biology.

[58]  G. M. Wilson,et al.  Phosphorylation of p40AUF1 Regulates Binding to A + U-rich mRNA-destabilizing Elements and Protein-induced Changes in Ribonucleoprotein Structure* , 2003, Journal of Biological Chemistry.

[59]  G. Tsokos,et al.  Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. , 2002, The Biochemical journal.

[60]  A. Shyu,et al.  Versatile Role for hnRNP D Isoforms in the Differential Regulation of Cytoplasmic mRNA Turnover , 2001, Molecular and Cellular Biology.

[61]  L. Dwyer-Nield,et al.  Differential Expression and Localization of the mRNA Binding Proteins, AU‐Rich Element mRNA Binding Protein (AUF1) and Hu Antigen R (HuR), in Neoplastic Lung Tissue , 2000, Molecular carcinogenesis.

[62]  A. Newton,et al.  Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* , 2000, The Journal of Biological Chemistry.

[63]  G. M. Wilson,et al.  Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. , 1998, Genomics.

[64]  M. Andjelkovic,et al.  High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity* , 1997, The Journal of Biological Chemistry.

[65]  P. Cohen,et al.  Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.

[66]  C. Demaria,et al.  AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation (*) , 1996, The Journal of Biological Chemistry.

[67]  J. Port,et al.  Regulation of the mRNA-binding Protein AUF1 by Activation of the -Adrenergic Receptor Signal Transduction Pathway (*) , 1996, The Journal of Biological Chemistry.

[68]  W Zhang,et al.  Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1 , 1993, Molecular and cellular biology.

[69]  G. Brewer,et al.  An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro , 1991, Molecular and cellular biology.