Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression.

[1]  M. Leist,et al.  Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages. , 2012, Antioxidants & redox signaling.

[2]  A. Lojek,et al.  New Role for L-Arginine in Regulation of Inducible Nitric-Oxide-Synthase-Derived Superoxide Anion Production in Raw 264.7 Macrophages , 2011, TheScientificWorldJournal.

[3]  S. Blankenberg,et al.  Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase , 2011, Circulation.

[4]  S. Dikalov.  Cross talk between mitochondria and NADPH oxidases. , 2011, Free radical biology & medicine.

[5]  B. Sarkadi,et al.  ABC transporters affect the detection of intracellular oxidants by fluorescent probes , 2011, Free radical research.

[6]  A. Lojek,et al.  Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin. , 2011, Immunobiology.

[7]  A. Cardounel,et al.  Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production. , 2009, Pharmacological research.

[8]  Yu Cao,et al.  Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes. , 2009, Atherosclerosis.

[9]  M. Číž,et al.  Continuous electrochemical monitoring of nitric oxide production in murine macrophage cell line RAW 264.7 , 2009, Analytical and bioanalytical chemistry.

[10]  A. Chagas,et al.  Asymmetric Dimethylarginine (ADMA) and Endothelial Dysfunction: Implications for Atherogenesis , 2009, Clinics.

[11]  R. Vanholder,et al.  Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[12]  M. Číž,et al.  Carvedilol and adrenergic agonists suppress the lipopolysaccharide-induced NO production in RAW 264.7 macrophages via the adrenergic receptors. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[13]  O. Eickelberg,et al.  From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases , 2009, BMC pulmonary medicine.

[14]  Bin Lou,et al.  Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes , 2009, European Journal of Clinical Pharmacology.

[15]  J. Zweier,et al.  Regulation of eNOS-derived superoxide by endogenous methylarginines. , 2008, Biochemistry.

[16]  H. Masuda.  Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction , 2008, International journal of urology : official journal of the Japanese Urological Association.

[17]  Guogang Zhang,et al.  Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C. , 2008, Vascular pharmacology.

[18]  S. Ugel,et al.  Role of arginine metabolism in immunity and immunopathology. , 2008, Immunobiology.

[19]  Maristela L Onozato,et al.  Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. , 2007, American journal of physiology. Heart and circulatory physiology.

[20]  A. Holian,et al.  Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells. , 2007, American journal of respiratory cell and molecular biology.

[21]  P. Vallance,et al.  Disruption of methylarginine metabolism impairs vascular homeostasis , 2007, Nature Medicine.

[22]  S. Legrand-Poels,et al.  NF-κB activation by reactive oxygen species: Fifteen years later , 2006 .

[23]  J. Pollock,et al.  Coupled and uncoupled NOS: separate but equal? Uncoupled NOS in endothelial cells is a critical pathway for intracellular signaling. , 2006, Circulation research.

[24]  J. Bełtowski,et al.  Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy. , 2006, Pharmacological reports : PR.

[25]  T. Meinertz,et al.  Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events. , 2005, European heart journal.

[26]  V. Bronte,et al.  Regulation of immune responses by L-arginine metabolism , 2005, Nature Reviews Immunology.

[27]  R. Böger.  Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor. , 2004, The Journal of nutrition.

[28]  M. Goligorsky,et al.  Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation. , 2004, American journal of physiology. Heart and circulatory physiology.

[29]  T. Münzel,et al.  ADMA and oxidative stress. , 2003, Atherosclerosis. Supplements.

[30]  P. Vallance,et al.  The DDAH/ADMA/NOS pathway. , 2003, Atherosclerosis. Supplements.

[31]  A. Rawlingson.  Nitric oxide, inflammation and acute burn injury. , 2003, Burns : journal of the International Society for Burn Injuries.

[32]  H. S. Hundal,et al.  Amino acid transporters: roles in amino acid sensing and signalling in animal cells. , 2003, The Biochemical journal.

[33]  M. Morimatsu,et al.  Regulation of Cytokine-Induced Nitric Oxide Synthesis by Asymmetric Dimethylarginine: Role of Dimethylarginine Dimethylaminohydrolase , 2003, Circulation research.

[34]  D. Mosser,et al.  The many faces of macrophage activation , 2003, Journal of leukocyte biology.

[35]  P. Vallance,et al.  S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[36]  L. Ignarro,et al.  Lipopolysaccharide-induced Expression of Interferon-β Mediates the Timing of Inducible Nitric-oxide Synthase Induction in RAW 264.7 Macrophages* , 2001, The Journal of Biological Chemistry.

[37]  R. Ye.  Regulation of nuclear factor κB activation by G‐protein‐coupled receptors , 2001, Journal of leukocyte biology.

[38]  K. Schmidt,et al.  Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  C. Cooper,et al.  Nitric oxide synthases: structure, function and inhibition , 2001 .

[40]  H. Lum,et al.  Oxidant stress and endothelial cell dysfunction. , 2001, American journal of physiology. Cell physiology.

[41]  S. Moncada,et al.  Biphasic Regulation of NF-κB Activity Underlies the Pro- and Anti-Inflammatory Actions of Nitric Oxide1 , 2001, The Journal of Immunology.

[42]  T. Gotoh,et al.  Regulation of nitric oxide production by arginine metabolic enzymes. , 2000, Biochemical and biophysical research communications.

[43]  D. Heistad,et al.  Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[44]  P. Tsao,et al.  Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[45]  S. Nussey,et al.  Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine. , 1999, Acta physiologica Scandinavica.

[46]  Ian G. Charles,et al.  Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. , 1999, The Biochemical journal.

[47]  P. Vallance,et al.  Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. , 1999, Cardiovascular research.

[48]  B. Mayer,et al.  Enzymatic function of nitric oxide synthases. , 1999, Cardiovascular research.

[49]  Guoyao Wu,et al.  Arginine metabolism: nitric oxide and beyond. , 1998, The Biochemical journal.

[50]  B. Mayer,et al.  Biosynthesis and action of nitric oxide in mammalian cells. , 1997, Trends in biochemical sciences.

[51]  U. Förstermann,et al.  Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. , 1997, Nitric oxide : biology and chemistry.

[52]  P. Vallance,et al.  Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase , 1996, British journal of pharmacology.

[53]  P. Vallance,et al.  Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases? , 1995, The American journal of physiology.

[54]  P. Vallance,et al.  Effects of guanidino and uremic compounds on nitric oxide pathways. , 1994, Kidney international.

[55]  D. Baltimore,et al.  Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element , 1993, Molecular and cellular biology.

[56]  Xuan Zhang,et al.  Effect of asymmetric dimethylarginine on MIF expression and TNF-α and IL-8 secretion in THP-1 monocytes-derived macrophages. , 2011, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[57]  L. Kubala,et al.  The effect of different molecular weight hyaluronan on macrophage physiology. , 2009, Neuro endocrinology letters.