Experimental odontogenic tumors produced by ethylnitrosourea injections and mechanical injuries.

The present study was carried out to investigate odontogenic tumor induction in the rats by injections of carcinogen N-ethyl-N-nitrosourea (ENU) coupled with incisional wounds. The animals which received local injections of ENU in the region of incisor tooth germ of the right mandible every other day for 19 days after birth coupled with incisional wounding in the same region at 2 and 8 days, developed odontogenic carcinomas. However, the animals which were given local injections of ENU in the region of incisor tooth germ but did not receive incisional wounds, showed no pathologic changes. The animals which received both local injections of physiologic salt solution and incisional wounds in the same manner as mentioned above, did not exhibit any pathologic changes. The present results indicate that local administration of carcinogen ENU coupled with mechanical injuries, namely incisional wounding, caused the production of odontogenic carcinomas in the incisor region of the mandible in rats.

[1]  Y. Kameyama,et al.  Epithelial dysplasia produced by carcinogen pretreatment and subsequent wounding. , 1989, Oral surgery, oral medicine, and oral pathology.

[2]  Y. Kameyama,et al.  Effect of excisional wounding on DMBA-induced hamster tongue carcinogenesis. , 1986, Journal of oral pathology.

[3]  M. Koike,et al.  Induction of odontogenic tumors in rats with N-nitrosomethylurea , 1983 .

[4]  A. Konstantinidis,et al.  Age-dependent odontogenic lesions in rats after a single i.p. injection of N-nitroso-N-methylurea. , 1983, Carcinogenesis.

[5]  G. Vawter,et al.  Odontogenic neoplasms in Wistar rats treated with N-methylnitrosourea. , 1983, Oral surgery, oral medicine, and oral pathology.

[6]  Y. Takei,et al.  Transplacental induction of ameloblastoma in rat using ethylnitrosourea (ENU) , 1981 .

[7]  T. Argyris,et al.  Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice. , 1980, The Journal of investigative dermatology.

[8]  J. Berman,et al.  Odontogenic tumours produced in Fischer rats by a single intraportal injection of methylnitrosourea. , 1980, Archives of oral biology.

[9]  M. Edwards Effects of n-methylnitrosourea on oral and dental tissues in the inbred Lewis rat. , 1980, Archives of oral biology.

[10]  A. Pound,et al.  Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats. , 1978, British Journal of Cancer.

[11]  M. Edwards Some effects of N-methylnitrosourea on the oral and odontogenic tissues of the Syrian golden hamster. , 1978, Archives of Oral Biology.

[12]  P. Kotin,et al.  Embryonal neoplasms in the opossum: a new model for solid tumors of infancy and childhood. , 1976, Science.

[13]  V. Craddock,et al.  Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for induction of liver carcinomas. , 1975, Chemico-biological interactions.

[14]  H. Ebling,et al.  N-Methyl-N-Nitrosourea-Induced Odontogenic Neoplasms in Rats , 1973, Journal of dental research.

[15]  T. Kôgo [An experimental study of odontogenic tumors in hamsters by N-nitrosomethylurea]. , 1972, Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan.

[16]  P. Magee,et al.  The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea. , 1969, British Journal of Cancer.

[17]  K. Herrold Odontogenic tumors and epidermoid carcinomas of the oral cavity. An experimental study in Syrain hamsters. , 1968, Oral surgery, oral medicine, and oral pathology.