Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells

[1]  L. Greene,et al.  Prevention of PC12 Cell Death by N-Acetylcysteine Requires Activation of the Ras Pathway , 1998, The Journal of Neuroscience.

[2]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[3]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[4]  S. Korsmeyer,et al.  Errors of homeostasis and deregulated apoptosis. , 1997, Current opinion in genetics & development.

[5]  S. Korsmeyer,et al.  BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity* , 1997, The Journal of Biological Chemistry.

[6]  J Downward,et al.  PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. , 1997, Trends in biochemical sciences.

[7]  D. Bar-Sagi,et al.  A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway , 1997, Cell.

[8]  D. Kaplan,et al.  Signal transduction by the neutrophin receptors , 1997 .

[9]  N. Hay,et al.  The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. , 1997, Genes & development.

[10]  A. Klippel,et al.  Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt , 1997, Molecular and cellular biology.

[11]  David R. Kaplan,et al.  Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.

[12]  B. Hemmings.  Akt Signaling--Linking Membrane Events to Life and Death Decisions , 1997, Science.

[13]  David R. Kaplan,et al.  Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt , 1997, Science.

[14]  D. Pot,et al.  A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain , 1997, Molecular and cellular biology.

[15]  P. Tsichlis,et al.  Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase , 1996, The Journal of Biological Chemistry.

[16]  Elizabeth Yang,et al.  Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL , 1996, Cell.

[17]  Y. Tan,et al.  Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2. , 1996, Biochemical and biophysical research communications.

[18]  A. Klippel,et al.  Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways , 1996, Molecular and cellular biology.

[19]  J. Downward,et al.  Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. , 1996, The EMBO journal.

[20]  W. Snider,et al.  Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[21]  J. Reppas,et al.  Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons , 1996, Neuroscience.

[22]  Michael E. Greenberg,et al.  Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.

[23]  N. Copeland,et al.  Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons , 1995, Cell.

[24]  B. Burgering,et al.  Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.

[25]  A. Ullrich,et al.  Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (*) , 1995, The Journal of Biological Chemistry.

[26]  Andrius Kazlauskas,et al.  The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.

[27]  G. Cooper,et al.  Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. , 1995, Science.

[28]  S. Korsmeyer.  Regulators of cell death. , 1995, Trends in genetics : TIG.

[29]  S. Korsmeyer,et al.  Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death , 1995, Cell.

[30]  G. Johnson,et al.  Ras-dependent growth factor regulation of MEK kinase in PC12 cells. , 1994, Science.

[31]  Michael J. Fry,et al.  Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.

[32]  C. Marshall,et al.  Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.

[33]  N. Copeland,et al.  Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. , 1994, Genes & development.

[34]  A. Ullrich,et al.  Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. , 1994, The EMBO journal.

[35]  A. Tolkovsky,et al.  Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal , 1994, The Journal of cell biology.

[36]  Z. Oltvai,et al.  Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. , 1993, Seminars in cancer biology.

[37]  S. Elledge,et al.  Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 , 1993, Nature.

[38]  T. Roberts,et al.  The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Wittinghofer,et al.  Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons , 1993, The Journal of cell biology.

[40]  D. Kaplan,et al.  SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells , 1993, Molecular and cellular biology.

[41]  R. Gerard,et al.  Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  M. Barbacid,et al.  Nerve growth factor mediates signal transduction through trk homodimer receptors , 1992, Neuron.

[43]  R. Bradshaw,et al.  Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[44]  S. Green,et al.  PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity , 1992, Neuron.

[45]  M. Cobb,et al.  Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[46]  U. Rapp,et al.  Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. , 1992, Genes & development.

[47]  Sheila M. Thomas,et al.  Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases , 1992, Cell.

[48]  J. Brugge,et al.  Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions , 1991, The Journal of cell biology.

[49]  L. Greene,et al.  Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[50]  D. Kaplan,et al.  The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. , 1991, Science.

[51]  D. Kaplan,et al.  Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF , 1991, Nature.

[52]  G. Cooper,et al.  Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells , 1990, Molecular and cellular biology.

[53]  T. Pawson,et al.  Mutational activation of c-raf-1 and definition of the minimal transforming sequence , 1990, Molecular and cellular biology.

[54]  G. Cooper,et al.  Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP , 1988, Molecular and cellular biology.

[55]  S. Halegoua,et al.  Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21 , 1986, Nature.

[56]  A. Ogura,et al.  Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line , 1985, Nature.

[57]  D. Bar-Sagi,et al.  Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation , 1985, Cell.

[58]  Cori Bargmann,et al.  Mechanism of activation of a human oncogene , 1982, Nature.

[59]  LA Greene,et al.  Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium , 1978, The Journal of cell biology.

[60]  L. Greene,et al.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[61]  L. Greene,et al.  Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells , 1975, Nature.

[62]  S. Korsmeyer,et al.  Bcl-2 gene family in the nervous system. , 1997, Annual review of neuroscience.

[63]  M. Greenberg,et al.  Intracellular signaling pathways activated by neurotrophic factors. , 1996, Annual review of neuroscience.