Postoperative decline in plasma aspirin‐esterase and cholinesterase activity in surgical patients

We studied preoperative and postoperative plasma hydrolysis of aspirin and plasma cholinesterase activity in surgical patients. Postoperative aspirin esterase and cholinesterase activities fell sharply (119 ± 32 μg ml h‐1 and 3746 ± 1068 U I‐1 respectively; P<0.01) in comparison to basal preoperative values (157 ± 33 μg ml h‐1 and 4620 ± 940 U I‐1 respectively, P ± 0.01). We suggest that alterations in plasma esterase during the postoperative period may be related to the metabolic response to anesthesia‐ and surgery‐induced stress.

[1]  H. Wynne,et al.  Human liver and plasma aspirin esterase , 1989, The Journal of pharmacy and pharmacology.

[2]  M. Ibsen,et al.  The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man , 1987, Acta anaesthesiologica Scandinavica.

[3]  K. Dohi,et al.  Role of free radicals in ischemic rat liver cell injury: prevention of damage by alpha-tocopherol administration. , 1986, Surgery.

[4]  F. Williams.  Clinical Significance of Esterases in Man , 1985, Clinical pharmacokinetics.

[5]  J. Biebuyck,et al.  New approaches to assessment of drug disposition in the surgical patient. , 1984, Anesthesiology.

[6]  K. Kutty.  Biological function of cholinesterase. , 1980, Clinical biochemistry.

[7]  P. Brooks,et al.  Plasma aspirin esterases in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterization and the importance of the enzymic components , 1980, European journal of clinical investigation.

[8]  D. Cuthbertson.  Alterations in metabolism following injury: part II. , 1980, Injury.

[9]  M. Tsuboi,et al.  Studies on aspirin esterase of human serum. , 1979, Japanese journal of pharmacology.

[10]  S. Glick,et al.  Radioimmunoassayable plasma vasopressin associated with surgery. , 1978, Archives of surgery.

[11]  V. Gupta,et al.  Serum aspirin esterase activity in women with habitual aspirin intake. , 1977, Clinica chimica acta; international journal of clinical chemistry.

[12]  S. Gelman.  Disturbances in hepatic blood flow during anesthesia and surgery. , 1976, Archives of surgery.

[13]  W J Jusko,et al.  Plasma and tissue protein binding of drugs in pharmacokinetics. , 1976, Drug metabolism reviews.

[14]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.