Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs
暂无分享,去创建一个
Jeffrey Weiss | S. Neuteboom | T. Chao | M. Palladino | S. Enna | K. McArthur | Bruno Hagenbuch | V. Macherla | B. Hagenbuch | B. Potts | Ta-Hsiang Chao | Saskia T C Neuteboom | Michael A Palladino | Katherine McArthur | Amanda Obaidat | Brett Wahlgren | Rama R Manam | Venkat R Macherla | G Kenneth Lloyd | Barbara C Potts | Salvatore J Enna | A. Obaidat | J. Weiss | G. Lloyd | R. Manam | Brett Wahlgren | K. Mcarthur | G. Kenneth Lloyd | Barbara C. Potts | Michael A. Palladino | Salvatore J. Enna
[1] P. Williams,et al. New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. , 2005, The Journal of organic chemistry.
[2] Hiroshi Yasui,et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. , 2005, Cancer cell.
[3] S. Neuteboom,et al. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. , 2005, Journal of medicinal chemistry.
[4] W. Dalton,et al. The proteasome. , 2004, Seminars in oncology.
[5] Jian Zhang,et al. The establishment of two paclitaxel‐resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines , 2007, The Prostate.
[6] J. Zalcberg,et al. MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines , 2000, Prostate Cancer and Prostatic Diseases.
[7] A. Goldberg,et al. The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites* , 2003, Journal of Biological Chemistry.
[8] V. Macherla,et al. Stereoselective enzymatic reduction of keto-salinosporamide to (−)-salinosporamide A (NPI-0052) , 2007 .
[9] T. Hideshima,et al. Molecular mechanisms of novel therapeutic approaches for multiple myeloma , 2002, Nature Reviews Cancer.
[10] C. Gui,et al. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. , 2008, European journal of pharmacology.
[11] D. Chauhan,et al. Proteasome inhibition in multiple myeloma: therapeutic implication. , 2005, Annual review of pharmacology and toxicology.
[12] M. Groll,et al. Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition. , 2009, Journal of medicinal chemistry.
[13] V. Stella,et al. A mechanistic and kinetic study of the beta-lactone hydrolysis of Salinosporamide A (NPI-0052), a novel proteasome inhibitor. , 2007, Journal of pharmaceutical sciences.
[14] S. Neuteboom,et al. Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides. , 2008, Journal of medicinal chemistry.
[15] A. Sartorelli,et al. Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice. , 2001, Biochemical and biophysical research communications.
[16] Sy Teisan,et al. Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus. , 2004, Journal of natural products.
[17] K. Anderson. Bortezomib therapy for myeloma. , 2004, Current hematology reports.
[18] J. Adams. The proteasome: a suitable antineoplastic target , 2004, Nature Reviews Cancer.
[19] Sy Teisan,et al. Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. , 2007, Journal of natural products.
[20] K. Anderson. Stem cell transplantation for myeloma. , 2004, Current hematology reports.
[21] R. Huber,et al. Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. , 2006, Journal of the American Chemical Society.
[22] William Fenical,et al. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. , 2003, Angewandte Chemie.