Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells

[1]  M. Berger,et al.  Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators , 2020, Frontiers in Pharmacology.

[2]  K. N. Diakopoulos,et al.  The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside , 2020, Cells.

[3]  S. Tooze,et al.  The Role of Autophagy in Pancreatic Cancer—Recent Advances , 2019, Biology.

[4]  Wenming Li,et al.  Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions , 2018, Autophagy.

[5]  Shuling Song,et al.  Crosstalk of ER stress‐mediated autophagy and ER‐phagy: Involvement of UPR and the core autophagy machinery , 2018, Journal of cellular physiology.

[6]  R. König,et al.  Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells , 2018, Cell Death & Disease.

[7]  Michael Lee,et al.  Knockout of ATG5 leads to malignant cell transformation and resistance to Src family kinase inhibitor PP2 , 2018, Journal of cellular physiology.

[8]  R. Jeffrey,et al.  Extrapancreatic perineural invasion in pancreatic adenocarcinoma , 2018, Abdominal Radiology.

[9]  M. Reni,et al.  Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategies. , 2017, Cancer treatment reviews.

[10]  C. Lindskog,et al.  A pathology atlas of the human cancer transcriptome , 2017, Science.

[11]  M. Falasca,et al.  Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies , 2017, International journal of molecular sciences.

[12]  Yan Jiang,et al.  CLDN1 Increases Drug Resistance of Non-Small Cell Lung Cancer by Activating Autophagy via Up-Regulation of ULK1 Phosphorylation , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[13]  A. Rucki,et al.  Shifting paradigm of developing biologics for the treatment of pancreatic adenocarcinoma. , 2017, Journal of gastrointestinal oncology.

[14]  Devin P. Sullivan,et al.  A subcellular map of the human proteome , 2017, Science.

[15]  T. Luedde,et al.  Current and future biomarkers for pancreatic adenocarcinoma , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[16]  M. Berger,et al.  Erufosine increases RhoB expression in oral squamous carcinoma cells independent of its tumor suppressive mode of action - a short report , 2017, Cellular Oncology.

[17]  Jianping Liu,et al.  Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins , 2016, Nature Communications.

[18]  O. Nureki,et al.  Crystal structure of Optineurin UBAN in complex with linear ubiquitin , 2016 .

[19]  M. Vooijs,et al.  LC3/GABARAP family proteins: autophagy‐(un)related functions , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  O. Nureki,et al.  Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis , 2016, Nature Communications.

[21]  R. Qin,et al.  Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells , 2016, Autophagy.

[22]  B. Yue,et al.  Optineurin: The autophagy connection. , 2016, Experimental eye research.

[23]  E. Giovannetti,et al.  Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma. , 2015, Seminars in cancer biology.

[24]  P. Cohen,et al.  Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease , 2015, Cell reports.

[25]  K. Koike,et al.  Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress , 2015, BMC Cancer.

[26]  C. Guillemette,et al.  BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism , 2015, Oncotarget.

[27]  S. Bloom,et al.  Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis , 2015, Disease Models & Mechanisms.

[28]  Caimin Xu,et al.  The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells. , 2015, Experimental cell research.

[29]  M. Hidalgo,et al.  Pancreatic cancer: from state-of-the-art treatments to promising novel therapies , 2015, Nature Reviews Clinical Oncology.

[30]  L. Pfeffer,et al.  Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells , 2015, Viruses.

[31]  Guang-Chao Chen,et al.  Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism , 2015, Autophagy.

[32]  Shumei Ma,et al.  Hsp90 regulates autophagy and plays a role in cancer therapy , 2015, Tumor Biology.

[33]  Yan Zhao,et al.  Mechanism and biological significance of the overexpression of IFITM3 in gastric cancer. , 2014, Oncology reports.

[34]  E. Holzbaur,et al.  Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation , 2014, Proceedings of the National Academy of Sciences.

[35]  H. Ji,et al.  Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. , 2014, Cancer cell.

[36]  S. Minoshima,et al.  Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology , 2014, PloS one.

[37]  A. Thorburn,et al.  Regulation of cell proliferation and migration by p62 through stabilization of Twist1 , 2014, Proceedings of the National Academy of Sciences.

[38]  Benjamin D. Smith,et al.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.

[39]  M. Hirota,et al.  Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. , 2014, European journal of cancer.

[40]  Yidong Chen,et al.  PELP1 oncogenic functions involve alternative splicing via PRMT6 , 2014, Molecular oncology.

[41]  B. Yue,et al.  Effects of mutations and deletions in the human optineurin gene , 2014, SpringerPlus.

[42]  A. Cuervo,et al.  Chaperone-mediated autophagy: roles in disease and aging , 2013, Cell Research.

[43]  D. Seo,et al.  PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion. , 2013, Biochemical and biophysical research communications.

[44]  M. Pawlita,et al.  High‐throughput SNP‐based authentication of human cell lines , 2013, International journal of cancer.

[45]  Lei Wang,et al.  Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma , 2013, Molecular Cancer.

[46]  U. Bauer,et al.  The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes , 2012, Nucleic acids research.

[47]  E. Laplantine,et al.  Toward an integrative view of Optineurin functions , 2012, Cell cycle.

[48]  Satya N. Das,et al.  Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma. , 2012, Cancer letters.

[49]  E. Laplantine,et al.  Optineurin: a new vision of cell division control. , 2012, Cell cycle.

[50]  T. Tan,et al.  Protein arginine methyltransferase 6 regulates embryonic stem cell identity. , 2012, Stem cells and development.

[51]  A. Bauch,et al.  Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. , 2012, Molecular cell.

[52]  B. Yue,et al.  Cellular and molecular biology of optineurin. , 2012, International review of cell and molecular biology.

[53]  K. Okamoto,et al.  Optineurin in neurodegenerative diseases , 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

[54]  Bo Liu,et al.  Mitochondrial ROS generation for regulation of autophagic pathways in cancer. , 2011, Biochemical and biophysical research communications.

[55]  P. Cohen,et al.  Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β* , 2011, The Journal of Biological Chemistry.

[56]  Sebastian A. Wagner,et al.  Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth , 2011, Science.

[57]  Marc Liesa,et al.  Pancreatic cancers require autophagy for tumor growth. , 2011, Genes & development.

[58]  J. Sellers,et al.  Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane , 2011, Molecular biology of the cell.

[59]  Y. Qiu,et al.  Processing of Optineurin in Neuronal Cells* , 2010, The Journal of Biological Chemistry.

[60]  A. Harris,et al.  Regulation of autophagy by ATF4 in response to severe hypoxia , 2010, Oncogene.

[61]  V. Radha,et al.  Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant , 2010, BMC Cell Biology.

[62]  A. Harris,et al.  Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia , 2009, Cell cycle.

[63]  G. Swarup,et al.  Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma , 2009, Ophthalmic Research.

[64]  G. Egea,et al.  Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus. , 2009, Molecular biology of the cell.

[65]  D. Klionsky,et al.  Autophagy and Human Disease , 2007, Cell cycle.

[66]  G. Diez-Roux,et al.  Optineurin Increases Cell Survival and Translocates to the Nucleus in a Rab8-dependent Manner upon an Apoptotic Stimulus* , 2006, Journal of Biological Chemistry.

[67]  G. Spudich,et al.  Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis , 2005, The Journal of cell biology.

[68]  A. Meijer,et al.  The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. , 1997, European journal of biochemistry.

[69]  K Y Hui,et al.  A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). , 1994, The Journal of biological chemistry.