ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
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Shuyi Zhang | Min Shi | Qiong Huang | Shumin Dong | Yang Zhao | Yajing Liu | Xingbin Hu | Z. Wen | Wanming He
[1] G. Georgiou,et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth , 2016, Nature Medicine.
[2] Mishal N. Patel,et al. British Society of Breast Radiology Annual Scientific Meeting 2016 , 2016, Breast Cancer Research.
[3] A. Gasbarrini,et al. Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches , 2016, Journal of cellular physiology.
[4] Tak W. Mak,et al. The current state of cancer metabolism , 2016, Nature Reviews Cancer.
[5] N. Hay,et al. Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? , 2016, Nature Reviews Cancer.
[6] Kyoung-Jae Won,et al. AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy , 2016, Nature.
[7] M. Nitti,et al. Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy , 2016, Oxidative medicine and cellular longevity.
[8] M. Santoro,et al. ROS homeostasis and metabolism: a dangerous liason in cancer cells , 2016, Cell Death and Disease.
[9] Christian M. Metallo,et al. PGC1α drives a metabolic block on prostate cancer progression , 2016, Nature Cell Biology.
[10] F. Sotgia,et al. Cancer stem cell metabolism , 2016, Breast Cancer Research.
[11] Xiaocui Wang,et al. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis , 2016, Science Translational Medicine.
[12] Anneleen Daemen,et al. mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells. , 2016, Cancer cell.
[13] E. Sokol,et al. AMPK promotes tolerance to Ras pathway inhibition by activating autophagy , 2016, Oncogene.
[14] J. Locasale,et al. The Warburg Effect: How Does it Benefit Cancer Cells? , 2016, Trends in biochemical sciences.
[15] R. Zhou,et al. MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells , 2016, Oncotarget.
[16] T. Yu,et al. Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling , 2016, Journal of bone oncology.
[17] C. Thompson,et al. The Emerging Hallmarks of Cancer Metabolism. , 2016, Cell metabolism.
[18] G. Mills,et al. Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines , 2015, International journal of oncology.
[19] B. Viollet,et al. AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis , 2015, Cell Death Discovery.
[20] R. Deberardinis,et al. PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth. , 2015, Molecular cell.
[21] Alexey Sergushichev,et al. Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. , 2015, Molecular cell.
[22] M. Bergo,et al. Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.
[23] R. Deberardinis,et al. Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.
[24] J. Velasco,et al. Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer. , 2015, Free radical biology & medicine.
[25] P. Urbánek,et al. Redox regulation of FoxO transcription factors , 2015, Redox biology.
[26] D. Hardie,et al. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. , 2015, Current opinion in cell biology.
[27] Verena Albert,et al. mTOR signaling in cellular and organismal energetics. , 2015, Current opinion in cell biology.
[28] S. Inoue,et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.
[29] F. Cecconi,et al. Oxidative stress and autophagy: the clash between damage and metabolic needs , 2014, Cell Death and Differentiation.
[30] G. Mills,et al. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. , 2015, American journal of cancer research.
[31] N. Ruderman,et al. Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. , 2014, Archives of biochemistry and biophysics.
[32] N. Hay,et al. The pentose phosphate pathway and cancer. , 2014, Trends in biochemical sciences.
[33] Y. Liao,et al. MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect , 2014, Oncogene.
[34] D. Tuveson,et al. The promise and perils of antioxidants for cancer patients. , 2014, The New England journal of medicine.
[35] S. Sollott,et al. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. , 2014, Physiological reviews.
[36] F. Viñals,et al. Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability* , 2014, The Journal of Biological Chemistry.
[37] R. Muschel,et al. Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia , 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[38] D. Sabatini,et al. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides , 2014, Nature.
[39] Michael N. Hall,et al. Making new contacts: the mTOR network in metabolism and signalling crosstalk , 2014, Nature Reviews Molecular Cell Biology.
[40] G. Mills,et al. Site-specific activation of AKT protects cells from death induced by glucose deprivation , 2014, Oncogene.
[41] C. Rommel,et al. PI3K and cancer: lessons, challenges and opportunities , 2014, Nature Reviews Drug Discovery.
[42] E. Larsson,et al. Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.
[43] F. Ross,et al. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells , 2014, The Biochemical journal.
[44] T. Mak,et al. Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.
[45] J. Debnath,et al. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK , 2013, Oncogene.
[46] Matija Snuderl,et al. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. , 2013, Cancer research.
[47] P. Puigserver,et al. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. , 2013, Cancer cell.
[48] Mohita Upadhyay,et al. The Warburg effect: insights from the past decade. , 2013, Pharmacology & therapeutics.
[49] A. Eijkelenboom,et al. FOXOs: signalling integrators for homeostasis maintenance , 2013, Nature reviews. Molecular cell biology.
[50] G. Filomeni,et al. Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells , 2012, Autophagy.
[51] C. Thompson,et al. Therapeutic targets in cancer cell metabolism and autophagy , 2012, Nature Biotechnology.
[52] T. Graeber,et al. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death , 2012, Molecular systems biology.
[53] Navdeep S. Chandel,et al. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress , 2012, Nature.
[54] P. Ray,et al. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. , 2012, Cellular signalling.
[55] T. Mak,et al. Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment , 2012, Proceedings of the National Academy of Sciences.
[56] D. Hardie,et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.
[57] P. Ward,et al. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.
[58] Yong‐Nyun Kim,et al. Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis , 2012, International journal of cell biology.
[59] Gordon B Mills,et al. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. , 2012, Cancer cell.
[60] P. Sharma,et al. A combination of 2-deoxy-d-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells , 2012, Tumor Biology.
[61] P. Sorensen,et al. The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis , 2011, Cell Death and Differentiation.
[62] D. Tindall,et al. Regulation of FOXO protein stability via ubiquitination and proteasome degradation. , 2011, Biochimica et biophysica acta.
[63] Jason W Locasale,et al. Metabolic flux and the regulation of mammalian cell growth. , 2011, Cell metabolism.
[64] J. Liu,et al. Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells. , 2011, Gynecologic oncology.
[65] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[66] Lei Xu,et al. Normalization of the vasculature for treatment of cancer and other diseases. , 2011, Physiological reviews.
[67] D. Clemmons,et al. Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells. , 2011, Endocrinology.
[68] G. Leclerc,et al. AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia , 2011, Molecular Cancer Therapeutics.
[69] O. Ilkayeva,et al. Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells* , 2010, The Journal of Biological Chemistry.
[70] G. Leclerc,et al. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia , 2010, Journal of molecular signaling.
[71] D. Clemmons,et al. AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. , 2010, Molecular endocrinology.
[72] Sang Gyun Kim,et al. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. , 2010, Molecular cell.
[73] C. Low,et al. Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. , 2010, Current oncology.
[74] C. Simone,et al. The AMPK-FoxO3A axis as a target for cancer treatment , 2010, Cell cycle.
[75] Mengwei Zang,et al. AMPK exerts dual regulatory effects on the PI3K pathway , 2010, Journal of molecular signaling.
[76] M. Pollak,et al. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells , 2010, Breast Cancer Research and Treatment.
[77] R. Deberardinis,et al. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. , 2009, Cancer research.
[78] C. Simone,et al. Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism , 2009, Autophagy.
[79] K. Kinzler,et al. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.
[80] L. Harhaji-Trajković,et al. AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells , 2009, Journal of cellular and molecular medicine.
[81] Hanna Y. Irie,et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.
[82] R. Shaw,et al. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression , 2009, Nature Reviews Cancer.
[83] Peng Huang,et al. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.
[84] K. Schulze-Osthoff,et al. Switching Akt: from survival signaling to deadly response , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.
[85] Irving L. Weissman,et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells , 2009, Nature.
[86] G. Ingravallo,et al. p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription , 2009, Cell Death and Differentiation.
[87] A. Gormand,et al. Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. , 2009, American journal of physiology. Endocrinology and metabolism.
[88] N. Hay,et al. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. , 2009, Seminars in cancer biology.
[89] N. Hay,et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. , 2008, Cancer cell.
[90] Julien Verrax,et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. , 2008, The Journal of clinical investigation.
[91] G. Semenza,et al. Uterine DCs are essential for pregnancy. , 2008, The Journal of clinical investigation.
[92] A. Marcus,et al. 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition , 2008, Molecular Cancer Therapeutics.
[93] J. Debnath,et al. Induction of autophagy during extracellular matrix detachment promotes cell survival. , 2007, Molecular biology of the cell.
[94] R. Deberardinis,et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.
[95] S. Gygi,et al. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.
[96] Jonathan Pevsner,et al. HIF-dependent antitumorigenic effect of antioxidants in vivo. , 2007, Cancer cell.
[97] Steven L McKnight,et al. Restriction of DNA Replication to the Reductive Phase of the Metabolic Cycle Protects Genome Integrity , 2007, Science.
[98] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[99] A. Tzatsos,et al. Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794* , 2007, Journal of Biological Chemistry.
[100] N. Hay,et al. The two TORCs and Akt. , 2007, Developmental cell.
[101] D. Spitz,et al. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. , 2007, Cancer research.
[102] D. Leroith,et al. The role of the IGF system in cancer growth and metastasis: overview and recent insights. , 2007, Endocrine reviews.
[103] E. White,et al. Role of Autophagy in Cancer: Management of Metabolic Stress , 2007, Autophagy.
[104] J. P. McCoy,et al. The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity* , 2006, Journal of Biological Chemistry.
[105] L. Bertrand,et al. AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. , 2006, American journal of physiology. Heart and circulatory physiology.
[106] J. Dyck,et al. Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity. , 2006, American journal of physiology. Heart and circulatory physiology.
[107] R. Jope,et al. AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. , 2006, Biochemical pharmacology.
[108] D. Vertommen,et al. Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491* , 2006, Journal of Biological Chemistry.
[109] M. Keleş,et al. Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer. , 2005, Cancer letters.
[110] A. Fukamizu,et al. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[111] S. Flanagan,et al. Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. , 2005, The Journal of biological chemistry.
[112] Y. Le Marchand-Brustel,et al. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. , 2005, Biochimie.
[113] A. Alavi,et al. Akt Stimulates Aerobic Glycolysis in Cancer Cells , 2004, Cancer Research.
[114] M. Guppy,et al. Cancer metabolism: facts, fantasy, and fiction. , 2004, Biochemical and biophysical research communications.
[115] M. Mueckler,et al. Glucose transport and apoptosis , 2000, Apoptosis.
[116] R. Medema,et al. Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty , 2003, Journal of leukocyte biology.
[117] D. Hardie,et al. 5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside* , 2001, The Journal of Biological Chemistry.
[118] E. Kandel,et al. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. , 2001, Genes & development.
[119] Pier Paolo Pandolfi,et al. The transcriptional role of PML and the nuclear body , 2000, Nature Cell Biology.
[120] Y. Lee,et al. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. , 1999, Free radical biology & medicine.
[121] P. Kuchel,et al. Elevated glutamate dehydrogenase flux in glucose-deprived hybridoma and myeloma cells: evidence from 1H/15N NMR. , 1998, Biotechnology and bioengineering.
[122] D. Spitz,et al. Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells* , 1998, The Journal of Biological Chemistry.
[123] B Chance,et al. Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.
[124] J. Folkman,et al. TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION , 1972, The Journal of experimental medicine.