Cevimeline-induced anti-inflammatory effect through upregulations of mucins in the ocular surface of a dry eye mouse model.

[1]  H. Kleinman,et al.  RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model , 2018, Scientific Reports.

[2]  K. Tsubota,et al.  Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency , 2018, Scientific Reports.

[3]  B. Ahn,et al.  Anti-inflammatory effect of hydroxyproline-GQDGLAGPK in desiccation stress-induced experimental dry eye mouse , 2017, Scientific Reports.

[4]  J. Lee,et al.  Effects of silk fibroin in murine dry eye , 2017, Scientific Reports.

[5]  Haeshin Lee,et al.  Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model. , 2017, Investigative ophthalmology & visual science.

[6]  Ik-Soo Lee,et al.  Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse , 2016, Nutrients.

[7]  I. Gipson Goblet cells of the conjunctiva: A review of recent findings , 2016, Progress in Retinal and Eye Research.

[8]  S. Saika,et al.  Ocular surface mucins and local inflammation—studies in genetically modified mouse lines , 2015, BMC Ophthalmology.

[9]  W. Ridder,et al.  New drugs for the treatment of dry eye disease , 2015 .

[10]  J. Lee,et al.  Effects of Quercetin in a Mouse Model of Experimental Dry Eye , 2015, Cornea.

[11]  D. Corry,et al.  IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. , 2015, Investigative ophthalmology & visual science.

[12]  P. Asbell,et al.  Clinical guidelines for management of dry eye associated with Sjögren disease. , 2015, The ocular surface.

[13]  J. Lee,et al.  Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model , 2015, Molecular vision.

[14]  D. Dartt,et al.  Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation , 2014, Current opinion in allergy and clinical immunology.

[15]  K. Tsubota,et al.  The effects of 3% diquafosol sodium application on the tear functions and ocular surface of the Cu,Zn-superoxide dismutase-1 (Sod1)–knockout mice , 2014, Molecular Vision.

[16]  S. Saika,et al.  Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice. , 2014, Investigative ophthalmology & visual science.

[17]  D. Dartt,et al.  Modulation of Conjunctival Goblet Cell Function by Inflammatory Cytokines , 2013, Mediators of inflammation.

[18]  S. Pflugfelder,et al.  T helper cytokines in dry eye disease. , 2013, Experimental eye research.

[19]  H. Clevers,et al.  Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. , 2013, The American journal of pathology.

[20]  F. Chaves,et al.  Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. , 2011, Investigative ophthalmology & visual science.

[21]  D. Corry,et al.  Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13 , 2011, Mucosal Immunology.

[22]  I. Gipson,et al.  Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells. , 2010, Experimental eye research.

[23]  F. Mantelli,et al.  Functions of ocular surface mucins in health and disease , 2008, Current opinion in allergy and clinical immunology.

[24]  S. Sel,et al.  Regulation of MUC16 by inflammatory mediators in ocular surface epithelial cell lines. , 2008, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[25]  X. Chen,et al.  MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients. , 2008, Experimental eye research.

[26]  De-Quan Li,et al.  Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. , 2007, Investigative ophthalmology & visual science.

[27]  Terry Kim,et al.  Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren's syndrome. , 2007, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[28]  J. Meijerink,et al.  Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. , 2006, Gastroenterology.

[29]  T. Medsger,et al.  Successful Treatment of Dry Mouth and Dry Eye Symptoms in Sjögren's Syndrome Patients With Oral Pilocarpine: A Randomized, Placebo-Controlled, Dose-Adjustment Study , 2004, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

[30]  I. Gipson,et al.  Character of ocular surface mucins and their alteration in dry eye disease. , 2004, The ocular surface.

[31]  P. Voulgari,et al.  Oral pilocarpine for the treatment of ocular symptoms in patients with Sjögren’s syndrome: a randomised 12 week controlled study , 2003, Annals of the rheumatic diseases.

[32]  J. Milbrandt,et al.  Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. , 2003, Investigative ophthalmology & visual science.

[33]  R. Dana,et al.  Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren syndrome. , 2002, Investigative ophthalmology & visual science.

[34]  K. Fukui,et al.  General Pharmacological Profile of the Novel Muscarinic Receptor Agonist SNI-2011, a Drug for Xerostomia in Sjögren’s Syndrome , 2002, Arzneimittelforschung.

[35]  M. Miyazaki,et al.  Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. , 2001, The Journal of nutrition.

[36]  I. Gipson,et al.  Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. , 2000, Archives of ophthalmology.

[37]  B. Reis,et al.  Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease1 , 2000 .

[38]  F. Vivino,et al.  Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. , 1999, Archives of internal medicine.

[39]  I. Gipson,et al.  Alteration of mucin in human conjunctival epithelia in dry eye. , 1998, Investigative ophthalmology & visual science.

[40]  T. Inatomi,et al.  Cellular origin of mucins of the ocular surface tear film. , 1998, Advances in experimental medicine and biology.

[41]  P. Agre,et al.  Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. , 1987, The Journal of biological chemistry.

[42]  E. Cadman,et al.  Sjögren's Syndrome , 1953, Medicine illustrated.