Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
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Goberdhan P Dimri | K. Itahana | J. Campisi | M. Acosta | G P Dimri | M Acosta | J Campisi | K Itahana
[1] W. Krek,et al. Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation. , 1999, Nucleic acids research.
[2] Goberdhan P Dimri,et al. Molecular and cell biology of replicative senescence. , 1994, Cold Spring Harbor symposia on quantitative biology.
[3] Peter A. Jones,et al. The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53 , 1998, Molecular and Cellular Biology.
[4] N. Dyson. The regulation of E2F by pRB-family proteins. , 1998, Genes & development.
[5] J. Barrett,et al. Investigation of the role of G1/S cell cycle mediators in cellular senescence. , 1993, Experimental cell research.
[6] H. Land,et al. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. , 1990, Nucleic acids research.
[7] G. Peters,et al. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence , 1996, Molecular and cellular biology.
[8] A. J. Millis,et al. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. , 1992, Experimental cell research.
[9] Yue Xiong,et al. ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways , 1998, Cell.
[10] D. Lowy,et al. Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins , 1994, Molecular and cellular biology.
[11] Miller Ad,et al. Improved Retroviral Vectors for Gene Transfer and Expression , 1989 .
[12] A. Jetten,et al. Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells. , 1993, Biochemical and biophysical research communications.
[13] J. Trent,et al. WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.
[14] R. Sager. Senescence as a mode of tumor suppression. , 1991, Environmental health perspectives.
[15] A. Levine,et al. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[16] T. Jacks,et al. Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 , 1996, Cell.
[17] A. Levine,et al. Functions of the MDM2 oncoprotein , 1999, Cellular and Molecular Life Sciences CMLS.
[18] V. Dulic,et al. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts , 1999, Molecular and Cellular Biology.
[19] S. Lowe,et al. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. , 1998, Genes & development.
[20] N. Dyson,et al. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. , 1998, Molecular cell.
[21] B. Howard,et al. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent , 1996, Molecular and cellular biology.
[22] C. Blattner,et al. Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53 , 1999, Molecular and Cellular Biology.
[23] J. Nevins,et al. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[24] G. Demers,et al. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells , 1991, Journal of virology.
[25] R. DePinho,et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus , 1999, Nature.
[26] J. Handa,et al. Senescence-associated β-galactosidase histochemistry for the primate eye , 1999 .
[27] W. Kaelin,et al. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[28] W. Lee,et al. Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[29] K. Helin,et al. Regulation of cell proliferation by the E2F transcription factors. , 1998, Current opinion in genetics & development.
[30] W. Sellers,et al. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter , 1994, Molecular and cellular biology.
[31] N. Holbrook,et al. Cellular aging and cell death , 1996 .
[32] K. Tsai,et al. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. , 1998, Molecular cell.
[33] G. Demers,et al. The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells , 1992, Journal of virology.
[34] J. R. Smith,et al. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. , 1994, Experimental cell research.
[35] Goberdhan P Dimri,et al. Replicative senescence, aging and growth-regulatory transcription factors. , 1996, Biological signals.
[36] J. Campisi,et al. Aging and Cancer: The Double‐Edged Sword of Replicative Senescence , 1997, Journal of the American Geriatrics Society.
[37] C. Sherr,et al. Tumor surveillance via the ARF-p53 pathway. , 1998, Genes & development.
[38] M. Greenberg,et al. E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation , 1996, Cell.
[39] G. Peters,et al. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts , 1998, Current Biology.
[40] Marc Vidal,et al. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F , 1992, Cell.
[41] P. Atadja,et al. Increased activity of p53 in senescing fibroblasts. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[42] Arnold J. Levine,et al. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 , 1990, Cell.
[43] Richard A. Ashmun,et al. Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.
[44] A. Miller,et al. Improved retroviral vectors for gene transfer and expression. , 1989, BioTechniques.
[45] H. Lovec,et al. E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. , 1994, Oncogene.
[46] Goberdhan P Dimri,et al. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. , 1994, The Journal of biological chemistry.
[47] J. Nevins,et al. Expression of transcription factor E2F1 induces quiescent cells to enter S phase , 1993, Nature.
[48] A. Look,et al. Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. , 1995, Genomics.
[49] J. Nevins,et al. Distinct roles for E2F proteins in cell growth control and apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[50] C. Harley,et al. Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.
[51] J. Nevins,et al. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes , 1995, Molecular and cellular biology.
[52] J. R. Smith,et al. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein , 1996, Molecular and cellular biology.
[53] C B Harley,et al. Telomere loss: mitotic clock or genetic time bomb? , 1991, Mutation research.
[54] C Roskelley,et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[55] A. Levine,et al. p53 and E2F-1 cooperate to mediate apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[56] M. Waring,et al. Footprinting at low temperatures: evidence that ethidium and other simple intercalators can discriminate between different nucleotide sequences. , 1987, Nucleic acids research.
[57] J. Sedivy. Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[58] L. Hayflick. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.
[59] J. Campisi. Replicative Senescence: An Old Lives' Tale? , 1996, Cell.
[60] J. Handa,et al. Senescence-associated beta-galactosidase histochemistry for the primate eye. , 1999, Investigative ophthalmology & visual science.
[61] B. Ames,et al. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. , 1998, The Biochemical journal.
[62] G. Roth,et al. Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta) , 1999, Journal of cellular physiology.
[63] Ken Chen,et al. The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 , 1998, Cell.
[64] J L Cleveland,et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. , 1998, Genes & development.
[65] G. Adami,et al. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts , 1998, Oncogene.
[66] J. R. Smith,et al. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. , 1989, Experimental cell research.
[67] J. McDougall,et al. Telomerase activation by the E6 gene product of human papillomavirus type 16 , 1996, Nature.
[68] O. Pereira-smith,et al. Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression , 1996, Science.
[69] S. Lowe,et al. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.
[70] M. Sherman,et al. Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72 , 1998, The Journal of Biological Chemistry.
[71] Kevin Ryan,et al. The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2 , 1998, The EMBO journal.
[72] D. Johnson,et al. Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[73] W. Lee,et al. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis , 1994, Molecular and cellular biology.
[74] W. Krek,et al. Increased levels of E2F-1-dependent DNA binding activity after UV- or γ-irradiation , 1999 .
[75] G. Wahl,et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. , 1994, Genes & development.
[76] T. Jacks,et al. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice , 1998, Nature Genetics.
[77] D. Woods,et al. Senescence of human fibroblasts induced by oncogenic Raf. , 1998, Genes & development.
[78] G. Hannon,et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[79] G. Nolan,et al. Production of high-titer helper-free retroviruses by transient transfection. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[80] Karen H. Vousden,et al. p14ARF links the tumour suppressors RB and p53 , 1998, Nature.