Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions

[1]  John P. Rice,et al.  Identification of common genetic risk variants for autism spectrum disorder , 2019, Nature Genetics.

[2]  Luís A. Nunes Amaral,et al.  Large-scale investigation of the reasons why potentially important genes are ignored , 2018, PLoS biology.

[3]  David J. Anderson,et al.  The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress , 2018, Cell.

[4]  Aviv Regev,et al.  Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq , 2018, Current Biology.

[5]  Warren W. Kretzschmar,et al.  Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression , 2017, Nature Genetics.

[6]  Jakob Grove,et al.  Common risk variants identified in autism spectrum disorder , 2017, bioRxiv.

[7]  Summer B. Thyme,et al.  Kctd13 deletion reduces synaptic transmission via increased RhoA , 2017, Nature.

[8]  P. Visscher,et al.  10 Years of GWAS Discovery: Biology, Function, and Translation. , 2017, American journal of human genetics.

[9]  H. Stefánsson,et al.  Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits , 2017, Nature Genetics.

[10]  G. Massicotte,et al.  Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice , 2017, Front. Mol. Neurosci..

[11]  Zev N. Kronenberg,et al.  De novo genic mutations among a Chinese autism spectrum disorder cohort , 2016, Nature Communications.

[12]  Xiaofeng Zhu,et al.  Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits , 2016, Nature Genetics.

[13]  Daning Lu,et al.  Chromosome conformation elucidates regulatory relationships in developing human brain , 2016, Nature.

[14]  G. Griebel,et al.  The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia , 2016, Scientific Reports.

[15]  Giulio Genovese,et al.  Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia , 2016, Nature Neuroscience.

[16]  M. Hattori,et al.  CUB and Sushi multiple domains 3 regulates dendrite development , 2016, Neuroscience Research.

[17]  F. Dautry,et al.  Post-transcriptional gene silencing activity of human GIGYF2. , 2016, Biochemical and biophysical research communications.

[18]  Tessa G Montague,et al.  Internal guide RNA interactions interfere with Cas9-mediated cleavage , 2016, Nature Communications.

[19]  Benjamin A. Logsdon,et al.  Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia , 2016, Nature Neuroscience.

[20]  Alessandro Filosa,et al.  Feeding State Modulates Behavioral Choice and Processing of Prey Stimuli in the Zebrafish Tectum , 2016, Neuron.

[21]  S. Horvath,et al.  Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap , 2016, Science.

[22]  Joseph M. Fernandez,et al.  Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2 , 2016, Neuron.

[23]  Giulio Genovese,et al.  Schizophrenia risk from complex variation of complement component 4 , 2016, Nature.

[24]  M. Owen,et al.  Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders , 2015, Progress in Neurobiology.

[25]  Christian Rosenmund,et al.  Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission , 2015, Neuron.

[26]  James E. Fitzgerald,et al.  Whole-brain activity mapping onto a zebrafish brain atlas , 2015, Nature Methods.

[27]  Florian Engert,et al.  A high-throughput assay for quantifying appetite and digestive dynamics. , 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

[28]  M. Gerstein,et al.  FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders , 2015, Cell.

[29]  Emily E Conklin,et al.  VideoHacking: Automated Tracking and Quantification of Locomotor Behavior with Open Source Software and Off-the-Shelf Video Equipment. , 2015, Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience.

[30]  Wenbin Gao,et al.  Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end? , 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[31]  M. Krebs,et al.  Mutation Burden of Rare Variants in Schizophrenia Candidate Genes , 2015, PloS one.

[32]  A. Regev,et al.  Spatial reconstruction of single-cell gene expression , 2015, Nature Biotechnology.

[33]  Randall T Peterson,et al.  15 years of zebrafish chemical screening. , 2015, Current opinion in chemical biology.

[34]  A. Schier,et al.  The study of psychiatric disease genes and drugs in zebrafish , 2015, Current Opinion in Neurobiology.

[35]  H. Baier,et al.  A dedicated visual pathway for prey detection in larval zebrafish , 2014, eLife.

[36]  S. Hyman,et al.  Improving and Accelerating Drug Development for Nervous System Disorders , 2014, Neuron.

[37]  Kathryn Roeder,et al.  De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. , 2014, Cell reports.

[38]  Herwig Baier,et al.  The Retinal Projectome Reveals Brain-Area-Specific Visual Representations Generated by Ganglion Cell Diversity , 2014, Current Biology.

[39]  Hiroyuki Miyamoto,et al.  Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures , 2014, Nature Communications.

[40]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[41]  B. Dias,et al.  A Role for Tac2, NkB, and Nk3 Receptor in Normal and Dysregulated Fear Memory Consolidation , 2014, Neuron.

[42]  Oriane Trouillard,et al.  De novo mutations in HCN1 cause early infantile epileptic encephalopathy , 2014, Nature Genetics.

[43]  E. van Wijk,et al.  CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia , 2014, PLoS genetics.

[44]  Bruce N Cuthbert,et al.  The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology , 2014, World psychiatry : official journal of the World Psychiatric Association.

[45]  M. Rossner,et al.  Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective , 2014, Cellular and Molecular Life Sciences.

[46]  Isabel Gauthier,et al.  Reduced habituation in patients with schizophrenia , 2013, Schizophrenia Research.

[47]  Chunyu Liu,et al.  A rare mutation of CACNA1C in a patient with Bipolar disorder, and decreased gene expression associated with a Bipolar-associated common SNP of CACNA1C in brain , 2013, Molecular Psychiatry.

[48]  W. Jiang,et al.  The novel complement inhibitor human CUB and Sushi multiple domains 1 (CSMD1) protein promotes factor I‐mediated degradation of C4b and C3b and inhibits the membrane attack complex assembly , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  M. Groudine,et al.  Molecular basis for chromatin binding and regulation of MLL5 , 2013, Proceedings of the National Academy of Sciences.

[50]  M. Daly,et al.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.

[51]  K. Hammerschmidt,et al.  A single gene defect causing claustrophobia , 2013, Translational Psychiatry.

[52]  Steven A. Harvey,et al.  A systematic genome-wide analysis of zebrafish protein-coding gene function , 2013, Nature.

[53]  Y. Nishimura,et al.  A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening , 2012, PloS one.

[54]  F. McKenzie,et al.  14q12 microdeletions excluding FOXG1 give rise to a congenital variant Rett syndrome-like phenotype , 2012, European Journal of Human Genetics.

[55]  A. Gingras,et al.  A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development , 2012, Molecular and Cellular Biology.

[56]  F. Rivier,et al.  14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements , 2012, European Journal of Human Genetics.

[57]  Thomas Brox,et al.  ViBE-Z: a framework for 3D virtual colocalization analysis in zebrafish larval brains , 2012, Nature Methods.

[58]  S. Lok,et al.  Increased exonic de novo mutation rate in individuals with schizophrenia , 2011, Nature Genetics.

[59]  M. Granato,et al.  Chemical modulation of memory formation in larval zebrafish , 2011, Proceedings of the National Academy of Sciences.

[60]  Joachim Wittbrodt,et al.  One for All—A Highly Efficient and Versatile Method for Fluorescent Immunostaining in Fish Embryos , 2011, PloS one.

[61]  Jai Y. Yu,et al.  Sexual Dimorphism in the Fly Brain , 2010, Current Biology.

[62]  N. Papalopulu,et al.  FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation , 2010, Development.

[63]  F. Beuschlein,et al.  Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits , 2010, Molecular Psychiatry.

[64]  S. Haggarty,et al.  Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation , 2010, Science.

[65]  Christian Laggner,et al.  Rapid behavior—based identification of neuroactive small molecules in the zebrafish , 2009, Nature chemical biology.

[66]  I. Guella,et al.  Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene , 2009, Neurobiology of Aging.

[67]  C. Schwarzer 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. , 2009, Pharmacology & therapeutics.

[68]  A. Sawa,et al.  Schizophrenia and epilepsy: Is there a shared susceptibility? , 2009, Neuroscience Research.

[69]  D. Rujescu,et al.  Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia , 2008, European Neuropsychopharmacology.

[70]  S. Nelson,et al.  The Fezf2–Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex , 2008, Proceedings of the National Academy of Sciences.

[71]  Alessandra Renieri,et al.  FOXG1 is responsible for the congenital variant of Rett syndrome. , 2008, American journal of human genetics.

[72]  A. Cao,et al.  Two patients with balanced translocations and autistic disorder: CSMD3 as a candidate gene for autism found in their common 8q23 breakpoint area , 2008, European Journal of Human Genetics.

[73]  E. Ahrens,et al.  Disruption of Foxg1 expression by knock-in of Cre recombinase: Effects on the development of the mouse telencephalon , 2007, Neuroscience.

[74]  H. Burgess,et al.  Modulation of locomotor activity in larval zebrafish during light adaptation , 2007, Journal of Experimental Biology.

[75]  Michael Granato,et al.  Sensorimotor Gating in Larval Zebrafish , 2007, The Journal of Neuroscience.

[76]  L. Luo,et al.  Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation , 2007, Cell.

[77]  Allan R. Jones,et al.  Genome-wide atlas of gene expression in the adult mouse brain , 2007, Nature.

[78]  Joyce Sprock,et al.  Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function. , 2006, Archives of general psychiatry.

[79]  Sonja M. Wojcik,et al.  A Shared Vesicular Carrier Allows Synaptic Corelease of GABA and Glycine , 2006, Neuron.

[80]  Michael R. Taylor,et al.  Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression , 2005, Neuroscience.

[81]  E. Courchesne,et al.  When Is the Brain Enlarged in Autism? A Meta-Analysis of All Brain Size Reports , 2005, Biological Psychiatry.

[82]  T. Ludwig,et al.  Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size , 2005, Molecular and Cellular Biology.

[83]  Stephan C. Schuster,et al.  Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells , 2004, Nature.

[84]  Euphrosyne Gouzoulis-Mayfrank,et al.  Sensitization and habituation of the acoustic startle reflex in patients with schizophrenia , 2004, Psychiatry Research.

[85]  S. Minoshima,et al.  A novel giant gene CSMD3 encoding a protein with CUB and sushi multiple domains: a candidate gene for benign adult familial myoclonic epilepsy on human chromosome 8q23.3-q24.1. , 2003, Biochemical and biophysical research communications.

[86]  A. B. Silva-Gómez,et al.  Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats , 2003, Brain Research.

[87]  Torsten Rohlfing,et al.  Nonrigid image registration in shared-memory multiprocessor environments with application to brains, breasts, and bees , 2003, IEEE Transactions on Information Technology in Biomedicine.

[88]  David J. Calkins,et al.  High‐resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons , 2002, The Journal of comparative neurology.

[89]  M. Hatten,et al.  Mice that lack astrotactin have slowed neuronal migration. , 2002, Development.

[90]  L. Breiman Random Forests , 2001, Machine Learning.

[91]  N. Klugbauer,et al.  Functional Embryonic Cardiomyocytes after Disruption of the L-type α1C (Ca v 1.2) Calcium Channel Gene in the Mouse* , 2000, The Journal of Biological Chemistry.

[92]  Alexander F. Schier,et al.  Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects , 2000, Nature Genetics.

[93]  Jerilyn A. Walker,et al.  Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). , 2000, BioTechniques.

[94]  Stephen L. Johnson,et al.  nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. , 1999, Development.

[95]  D. Fisher,et al.  Involvement of Microphthalmia in the Inhibition of Melanocyte Lineage Differentiation and of Melanogenesis by Agouti Signal Protein* , 1998, The Journal of Biological Chemistry.

[96]  V. Giguère,et al.  Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer , 1998, Mechanisms of Development.

[97]  D A Kane,et al.  The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. , 1996, Development.

[98]  A. Schier,et al.  Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. , 1996, Development.

[99]  A. Schier,et al.  A genetic screen for mutations affecting embryogenesis in zebrafish. , 1996, Development.

[100]  홀덴 데이비드윌리암,et al.  Identification of genes , 1995 .

[101]  R. Sidman,et al.  Staggerer, a New Mutation in the Mouse Affecting the Cerebellum , 1962, Science.

[102]  Joseph M. Fernandez,et al.  Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene , CNTNAP 2 Highlights , 2016 .

[103]  M. Hibi,et al.  Function of strawberry notch family genes in the zebrafish brain development. , 2011, The Kobe journal of medical sciences.

[104]  Geoffrey E. Hinton,et al.  Visualizing Data using t-SNE , 2008 .

[105]  K. Holubar Two patients. , 2006, Journal of the American Academy of Dermatology.

[106]  T. Ludwig,et al.  Role for Akt3/protein kinase Bgamma in attainment of normal brain size. , 2005, Molecular and cellular biology.

[107]  J. Eisen,et al.  Patterning the zebrafish central nervous system. , 2002, Results and problems in cell differentiation.

[108]  D. Lewis,et al.  Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. , 2000, Archives of general psychiatry.

[109]  윤호주 전사인자(transcription factor)와 기관지천식 , 1999 .

[110]  I. Feinberg,et al.  Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? , 1982, Journal of psychiatric research.