Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles.

[1]  J. Vennerstrom,et al.  Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. , 2000, Biochimica et biophysica acta.

[2]  Peter W. Stephens,et al.  The structure of malaria pigment β-haematin , 2000, Nature.

[3]  K. Kirk,et al.  Transport and trafficking in the malaria-infected erythrocyte. , 1999, Parasitology today.

[4]  D. Taramelli,et al.  A Novel Endogenous Antimalarial: Fe(II)-Protoporphyrin IXα (Heme) Inhibits Hematin Polymerization to β-Hematin (Malaria Pigment) and Kills Malaria Parasites† , 1999 .

[5]  H. Ginsburg,et al.  Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum , 1999, The Journal of cell biology.

[6]  D. Taramelli,et al.  Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by β‐haematin (malaria pigment) , 1998, FEBS letters.

[7]  G. Elder.  Update on enzyme and molecular defects in porphyria , 1998 .

[8]  H. Matile,et al.  An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. , 1998, Biochemical pharmacology.

[9]  X. Shen,et al.  Effects of additional iron-chelators on Fe(2+)-initiated lipid peroxidation: evidence to support the Fe2+ ... Fe3+ complex as the initiator. , 1997, Journal of inorganic biochemistry.

[10]  T. Egan,et al.  Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX. , 1997, Journal of inorganic biochemistry.

[11]  K. Kuželová,et al.  Kinetics of heme interaction with heme-binding proteins: the effect of heme aggregation state. , 1997, Biochimica et biophysica acta.

[12]  P. Arese,et al.  Malarial pigment (haemozoin): a very active 'inert' substance. , 1997, Annals of tropical medicine and parasitology.

[13]  D. Taramelli,et al.  Non‐iron porphyrins inhibit β‐haematin (malaria pigment) polymerisation , 1997 .

[14]  R. Dinnebier,et al.  Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction* , 1997, The Journal of Biological Chemistry.

[15]  D. Sullivan,et al.  On the molecular mechanism of chloroquine's antimalarial action. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  P. Kremsner,et al.  Effects of Plasmodium vinckei hemozoin on the production of oxygen radicals and nitrogen oxides in murine macrophages. , 1996, The American journal of tropical medicine and hygiene.

[17]  D. Taramelli,et al.  The heme moiety of malaria pigment (β-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-α production by lipopolysaccharide-stimulated macrophages , 1995 .

[18]  H. Ginsburg,et al.  Heme Degradation in the Presence of Glutathione , 1995, The Journal of Biological Chemistry.

[19]  L. Barclay,et al.  Partitioning and antioxidant action of the water-soluble antioxidant, Trolox, between the aqueous and lipid phases of phosphatidylcholine membranes: 14C tracer and product studies. , 1995, Biochimica et biophysica acta.

[20]  D. Ferguson,et al.  Intraleucocytic malaria pigment and prognosis in severe malaria. , 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[21]  T. Egan,et al.  Quinoline anti‐malarial drugs inhibit spontaneous formation of β‐haematin (malaria pigment) , 1994 .

[22]  J. Nourooz-Zadeh,et al.  Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. , 1994, Analytical biochemistry.

[23]  S. Schreier,et al.  Hemin-induced lipid membrane disorder and increased permeability: a molecular model for the mechanism of cell lysis. , 1993, Archives of biochemistry and biophysics.

[24]  B. S. Robinson,et al.  Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei. , 1992, The Journal of clinical investigation.

[25]  M. Suzuki,et al.  The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation. , 1991, Biochimica et biophysica acta.

[26]  D. Goldberg,et al.  An iron-carboxylate bond links the heme units of malaria pigment. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[27]  U. Muller-eberhard,et al.  The influence of heme-binding proteins in heme-catalyzed oxidations. , 1988, Archives of biochemistry and biophysics.

[28]  M. Davies,et al.  Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with heme-proteins by electron spin resonance spectroscopy. , 1988, Biochimica et biophysica acta.

[29]  C. D. Fitch,et al.  The state of ferriprotoporphyrin IX in malaria pigment. , 1987, The Journal of biological chemistry.

[30]  L. Marnett,et al.  Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin. , 1985, The Journal of biological chemistry.

[31]  L. Marnett,et al.  Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides. , 1985, The Journal of biological chemistry.

[32]  H. Ginsburg,et al.  Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers. , 1984, Chemistry and physics of lipids.

[33]  U. Muller-eberhard,et al.  Kinetics of the interaction of hemin liposomes with heme binding proteins. , 1984, Biochemistry.

[34]  E. Wheeler.  Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen. A proposed method for P-450 kinetic studies. , 1983, Biochemical and biophysical research communications.

[35]  M. Pfaller,et al.  Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex , 1982, Antimicrobial Agents and Chemotherapy.

[36]  A. Chou,et al.  Mechanism of hemolysis induced by ferriprotoporphyrin IX. , 1981, The Journal of clinical investigation.

[37]  A. Chou,et al.  Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. , 1980, The Journal of clinical investigation.

[38]  B. Ketterer,et al.  Interactions of small molecules with phospholipid bilayers. Binding to egg phosphatidylcholine of some organic anions (bromosulphophthalein, oestrone sulphate, haem and bilirubin) that bind to ligandin and aminoazo-dye-binding protein A. , 1979, The Biochemical journal.

[39]  Y. Hatefi,et al.  Lipid oxidation in biological membranes. Electron transfer proteins as initiators of lipid autoxidation. , 1975, Archives of biochemistry and biophysics.

[40]  S. B. Brown,et al.  Aggregation of ferrihaems. Dimerization and protolytic equilibria of protoferrihaem and deuteroferrihaem in aqueous solution. , 1970, The Biochemical journal.

[41]  D. Vance,et al.  Quantitative determination of the neutral glycosyl ceramides in human blood. , 1967, Journal of lipid research.

[42]  G. R. Bartlett.  Phosphorus assay in column chromatography. , 1959, The Journal of biological chemistry.

[43]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[44]  D. Sullivan,et al.  Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. , 1997, Annual review of microbiology.

[45]  O. Augusto,et al.  Inhibitory effect of chloroquine on the peroxidase activity of ferriprotoporphyrin IX , 1995 .

[46]  J. Golenser,et al.  The survival of Plasmodium Under oxidant stress. , 1991, Parasitology today.

[47]  R. Hebbel.  The sickle erythrocyte in double jeopardy: autoxidation and iron decompartmentalization. , 1990, Seminars in hematology.

[48]  S. Aust,et al.  Microsomal lipid peroxidation. , 1978, Methods in enzymology.

[49]  E. Work,et al.  Laboratory techniques in biochemistry and molecular biology , 1969 .