Effects of Exposure to Welding Fume on Lung Function: Results from the German WELDOX Study.

The association between exposure to welding fume and chronic obstructive pulmonary disease (COPD) has been insufficiently clarified. In this study we assessed the influence of exposure to welding fume on lung function parameters. We investigated forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and expiratory flow rates in 219 welders. We measured current exposure to respirable particles and estimated a worker's lifetime exposure considering welding techniques, working conditions and protective measures at current and former workplaces. Multiple regression models were applied to estimate the influence of exposure to welding fume, age, and smoking on lung function. We additionally investigated the duration of working as a welder and the predominant welding technique. The findings were that age- and smoking-adjusted lung function parameters showed no decline with increasing duration, current exposure level, and lifetime exposure to welding fume. However, 15% of the welders had FEV1/FVC below the lower limit of normal, but we could not substantiate the presence of an association with the measures of exposure. Adverse effects of cigarette smoking were confirmed. In conclusion, the study did not support the notion of a possible detrimental effect of exposure to welding fume on lung function in welders.

[1]  Buist As.  Standardization of spirometry. , 1987 .

[2]  P. Blanc.  Occupation and COPD: A Brief Review , 2012, The Journal of asthma : official journal of the Association for the Care of Asthma.

[3]  J E Cotes,et al.  Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. , 1993, The European respiratory journal. Supplement.

[4]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[5]  J. Antonini,et al.  Health Effects of Welding , 2003, Critical reviews in toxicology.

[6]  P. Cullinan,et al.  Welding, longitudinal lung function decline and chronic respiratory symptoms: a systematic review of cohort studies , 2012, European Respiratory Journal.

[7]  I. C. Stevenson,et al.  Longitudinal respiratory survey of shipyard workers: effects of trade and atopic status. , 1990, British journal of industrial medicine.

[8]  C. Porsbjerg,et al.  The value of exhaled nitric oxide to identify asthma in smoking patients with asthma-like symptoms. , 2012, Respiratory Medicine.

[9]  T. Brüning,et al.  Levels and predictors of airborne and internal exposure to manganese and iron among welders , 2012, Journal of Exposure Science and Environmental Epidemiology.

[10]  T. Brüning,et al.  Levels and predictors of airborne and internal exposure to chromium and nickel among welders--results of the WELDOX study. , 2013, International journal of hygiene and environmental health.

[11]  A. Touranchet,et al.  Increased lung function decline in blue-collar workers exposed to welding fumes. , 2012, Chest.

[12]  N. Pearce,et al.  Respiratory symptoms, across-shift lung function changes and lifetime exposures of welders in New Zealand. , 1997, Scandinavian journal of work, environment & health.

[13]  J E Cotes,et al.  Respiratory health of young shipyard welders and other tradesmen studied cross sectionally and longitudinally. , 1995, Occupational and environmental medicine.

[14]  W. Bailey,et al.  Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution , 2023, Medical science monitor : international medical journal of experimental and clinical research.

[15]  S. Gabriel,et al.  The MGU - a monitoring system for the collection and documentation of valid workplace exposure data , 2010 .

[16]  S. Stanojevic,et al.  Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations , 2012, European Respiratory Journal.

[17]  K. Straif,et al.  Welding and lung cancer in a pooled analysis of case-control studies. , 2013, American journal of epidemiology.

[18]  A. Menezes,et al.  The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study , 2012, European Respiratory Journal.

[19]  J Stocks,et al.  Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction , 2008, Thorax.

[20]  S. Hurd,et al.  Global Strategy for the Diagnosis, Management and Prevention of COPD: 2003 update , 2003, European Respiratory Journal.

[21]  John L. Hankinson,et al.  Standardization of Spirometry, 1994 Update. American Thoracic Society. , 1995, American journal of respiratory and critical care medicine.

[22]  P. Boffetta,et al.  Development and use of a welding process exposure matrix in a historical prospective study of lung cancer risk in European welders. , 1993, International journal of epidemiology.

[23]  N. Pearce,et al.  Two year follow up of pulmonary function values among welders in New Zealand. , 1999, Occupational and environmental medicine.

[24]  T. Bernard,et al.  Job-Related Osteoarthritis of the Knee, Foot, Hand, and Cervical Spine , 2010, Journal of occupational and environmental medicine.

[25]  T. Brüning,et al.  Exhaled breath condensate and airway inflammation , 2009, Current opinion in allergy and clinical immunology.

[26]  Markus Berges,et al.  Exposure to Inhalable, Respirable, and Ultrafine Particles in Welding Fume , 2012, The Annals of occupational hygiene.

[27]  T. Brüning,et al.  Reduction in welding fume and metal exposure of stainless steel welders: an example from the WELDOX study , 2013, International Archives of Occupational and Environmental Health.

[28]  J. Cotes,et al.  Longitudinal effects of change in body mass on measurements of ventilatory capacity. , 1996, Thorax.