Second Near-Infrared Conjugated Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy.

Photothermal conversion in the second near-infrared (NIR-II) window allows deeper penetration and higher exposure to lasers, but examples of NIR-II photothermal agents are mainly formulated by inorganic compounds. In view of the underlying influence of inorganic materials, a novel NIR-II photothermal nanoagent based on a narrow band gap D-A conjugated polymer (TBDOPV-DT) with 2,2-bithiophene as the donor and thiophene-fused benzodifurandione-based oligo( p-phenylenevinylene) as the acceptor has been developed. More importantly, TBDOPV-DT nanoparticles (TBDOPV-DT NPs) are demonstrated to combine excellent photoacoustic imaging (PAI) and photothermal therapy (PTT) ability. TBDOPV-DT NPs exhibit dramatic photostability and heating reproducibility with a photothermal conversion efficiency of 50%. Especially, the NPs possess a remarkable PTT effect toward cancer cells in vitro and can eliminate tumor cells completely in vivo under 1064 nm laser irradiation, while no appreciable side effects have been observed. This study achieves PAI-guided cancer therapy and sheds light on the future of using organic polymer NPs for the NIR-II PTT of cancer.

[1]  Zhanfang Ma,et al.  PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window. , 2015, Biomaterials.

[2]  M. Melancon,et al.  Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. , 2011, Accounts of chemical research.

[3]  Qun-li Lei,et al.  Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging , 2017 .

[4]  Zhigang Xie,et al.  Nanoprodrug of retinoic acid-modified paclitaxel. , 2017, Organic & biomolecular chemistry.

[5]  H. Choi,et al.  In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes. , 2009, ACS Nano.

[6]  Xin Cai,et al.  Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. , 2013, ACS nano.

[7]  Xuesi Chen,et al.  Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. , 2017, Acta biomaterialia.

[8]  Renu Malhotra,et al.  In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer. , 2015, Nano letters.

[9]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[10]  Jun Ma,et al.  Constructing Uniform Core-Shell PPy@PANI Composites with Tunable Shell Thickness toward Enhancement in Microwave Absorption. , 2015, ACS applied materials & interfaces.

[11]  Chi‐Kuang Sun,et al.  Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures. , 2009, Journal of the American Chemical Society.

[12]  Rebecca Richards-Kortum,et al.  Self-assembly synthesis, tumor cell targeting, and photothermal capabilities of antibody-coated indocyanine green nanocapsules. , 2010, Journal of the American Chemical Society.

[13]  Shaoqin Liu,et al.  Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent. , 2015, Biomaterials.

[14]  Kai Yang,et al.  Organic stealth nanoparticles for highly effective in vivo near-infrared photothermal therapy of cancer. , 2012, ACS nano.

[15]  H. Dai,et al.  High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes , 2010, Nano research.

[16]  X. Jing,et al.  Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers , 2016, Advanced materials.

[17]  Kinam Kim,et al.  Full surface embedding of gold clusters on silicon nanowires for efficient capture and photothermal therapy of circulating tumor cells. , 2012, Nano letters.

[18]  Kai Yang,et al.  In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles , 2012, Advanced materials.

[19]  Li Wan,et al.  Photoacoustic Imaging Guided Near‐Infrared Photothermal Therapy Using Highly Water‐Dispersible Single‐Walled Carbon Nanohorns as Theranostic Agents , 2014 .

[20]  D. Carroll,et al.  Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes , 2009, ACS nano.

[21]  Kyung-Hwa Yoo,et al.  Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. , 2011, Angewandte Chemie.

[22]  Ming-Fong Tsai,et al.  Au nanorod design as light-absorber in the first and second biological near-infrared windows for in vivo photothermal therapy. , 2013, ACS nano.

[23]  Yan Lyu,et al.  Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons. , 2016, Journal of the American Chemical Society.

[24]  Yuliang Zhao,et al.  Smart Albumin‐Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation , 2015, Advanced materials.

[25]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[26]  Mengya Liu,et al.  Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window. , 2014, Journal of the American Chemical Society.

[27]  Yun Gao,et al.  A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy. , 2017, Chemical communications.

[28]  Shiming Zhang,et al.  Highly Efficient NIR-II Photothermal Conversion Based on an Organic Conjugated Polymer , 2017 .

[29]  Xiaoyuan Chen,et al.  Synergistic thermoradiotherapy based on PEGylated Cu3BiS3 ternary semiconductor nanorods with strong absorption in the second near-infrared window. , 2017, Biomaterials.

[30]  Xuesi Chen,et al.  Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates. , 2009, Journal of biomedical materials research. Part A.

[31]  Huan Xu,et al.  Iron oxide @ polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect. , 2013, ACS nano.

[32]  Xuesi Chen,et al.  Receptor and Microenvironment Dual-Recognizable Nanogel for Targeted Chemotherapy of Highly Metastatic Malignancy. , 2017, Nano letters.

[33]  Duyang Gao,et al.  Robust ICG theranostic nanoparticles for folate targeted cancer imaging and highly effective photothermal therapy. , 2014, ACS applied materials & interfaces.

[34]  Emily B. Ehlerding,et al.  Bioresponsive Polyoxometalate Cluster for Redox-Activated Photoacoustic Imaging-Guided Photothermal Cancer Therapy. , 2017, Nano letters.

[35]  X. Qu,et al.  New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide , 2013, Advanced materials.

[36]  Xiaogang Qu,et al.  Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease , 2012, Advanced materials.

[37]  Chen-Sheng Yeh,et al.  Near-infrared light-responsive nanomaterials in cancer therapeutics. , 2014, Chemical Society reviews.

[38]  Chen-Sheng Yeh,et al.  Rattle‐Type Fe3O4@CuS Developed to Conduct Magnetically Guided Photoinduced Hyperthermia at First and Second NIR Biological Windows , 2015 .

[39]  S. Wise.  Nanocarriers as an emerging platform for cancer therapy , 2007 .

[40]  Han‐Gon Choi,et al.  Rabies Virus‐Inspired Silica‐Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors , 2017, Advanced materials.

[41]  Kai Yang,et al.  Nano-Graphene in Biomedicine: Theranostic Applications , 2013 .

[42]  Wei Huang,et al.  Diketopyrrolopyrrole-Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy. , 2017, ACS nano.

[43]  Xiaodi Zhang,et al.  Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging-Guided Tumor Photothermal Therapy. , 2016, ACS nano.

[44]  赵鹏飞,et al.  IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy , 2013 .

[45]  V. Zharov,et al.  Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. , 2009, Nature nanotechnology.

[46]  M. C. Mancini,et al.  Bioimaging: second window for in vivo imaging. , 2009, Nature nanotechnology.

[47]  Mingyuan Gao,et al.  Light‐Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo , 2017, Advanced materials.

[48]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[49]  Lev Dykman,et al.  Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. , 2011, Chemical Society reviews.

[50]  X. Jing,et al.  Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents. , 2015, Colloids and surfaces. B, Biointerfaces.

[51]  Zhuang Liu,et al.  Mesoporous Silica Coated Single‐Walled Carbon Nanotubes as a Multifunctional Light‐Responsive Platform for Cancer Combination Therapy , 2015 .

[52]  O. Farokhzad,et al.  Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics. , 2015, Angewandte Chemie.

[53]  Kai Yang,et al.  Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy. , 2017, ACS nano.

[54]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .

[55]  龚萍,et al.  Single-Step Assembly of DOX/ICG Loaded Lipid Polymer Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy , 2013 .

[56]  Fuyou Li,et al.  NIR photothermal therapy using polyaniline nanoparticles. , 2013, Biomaterials.

[57]  Hui-Fen Wu,et al.  Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells. , 2013, Biomaterials.

[58]  Zhishen Ge,et al.  Ultrastable Near‐Infrared Conjugated‐Polymer Nanoparticles for Dually Photoactive Tumor Inhibition , 2017, Advanced materials.

[59]  Zhuang Liu,et al.  Photosensitizer-Conjugated Albumin-Polypyrrole Nanoparticles for Imaging-Guided In Vivo Photodynamic/Photothermal Therapy. , 2015, Small.

[60]  N. Thakor,et al.  Biocompatible conjugated polymer nanoparticles for efficient photothermal tumor therapy. , 2015, Small.

[61]  Liang Cheng,et al.  Functional nanomaterials for phototherapies of cancer. , 2014, Chemical reviews.

[62]  Qiushi Ren,et al.  Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells , 2013, Advanced materials.

[63]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[64]  X. Qu,et al.  Tumor Microenvironment Activated Photothermal Strategy for Precisely Controlled Ablation of Solid Tumors upon NIR Irradiation , 2015 .