Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations

Outdoor air pollution is a major contributor to the burden of disease worldwide. Most of the global population resides in places where air pollution levels, because of emissions from industry, power generation, transportation, and domestic burning, considerably exceed the World Health Organization's health‐based air‐quality guidelines. Outdoor air pollution poses an urgent worldwide public health challenge because it is ubiquitous and has numerous serious adverse human health effects, including cancer. Currently, there is substantial evidence from studies of humans and experimental animals as well as mechanistic evidence to support a causal link between outdoor (ambient) air pollution, and especially particulate matter (PM) in outdoor air, with lung cancer incidence and mortality. It is estimated that hundreds of thousands of lung cancer deaths annually worldwide are attributable to PM air pollution. Epidemiological evidence on outdoor air pollution and the risk of other types of cancer, such as bladder cancer or breast cancer, is more limited. Outdoor air pollution may also be associated with poorer cancer survival, although further research is needed. This report presents an overview of outdoor air pollutants, sources, and global levels, as well as a description of epidemiological evidence linking outdoor air pollution with cancer incidence and mortality. Biological mechanisms of air pollution‐derived carcinogenesis are also described. This report concludes by summarizing public health/policy recommendations, including multilevel interventions aimed at individual, community, and regional scales. Specific roles for medical and health care communities with regard to prevention and advocacy and recommendations for further research are also described.

[1]  P. Laktionov,et al.  Long interspersed nuclear element-1 methylation status in the circulating DNA from blood of patients with malignant and chronic inflammatory lung diseases. , 2020, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[2]  J. Christensen,et al.  Long-term exposure to PM2.5 and its constituents and risk of Non-Hodgkin lymphoma in Denmark: A population-based case-control study. , 2020, Environmental research.

[3]  Joshua D. Higbee,et al.  Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults , 2020, Cancer Causes & Control.

[4]  C. A. Pope,et al.  Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients , 2020, Cancer Epidemiology, Biomarkers & Prevention.

[5]  R. Burnett,et al.  Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort , 2020, International journal of cancer.

[6]  J. Christensen,et al.  Long-Term Exposure to Air Pollution and Risk of Non-Hodgkin lymphoma in Denmark: A Population-based Case-Control Study. , 2020, International journal of cancer.

[7]  D. Jiang,et al.  Alu Methylation and Risk of Cancer: A Meta-analysis. , 2020, The American journal of the medical sciences.

[8]  G. Leikauf,et al.  Mechanisms of ultrafine particle-induced respiratory health effects , 2020, Experimental & Molecular Medicine.

[9]  E. Bezirtzoglou,et al.  Environmental and Health Impacts of Air Pollution: A Review , 2020, Frontiers in Public Health.

[10]  J. Manjourides,et al.  The impact of long-term PM2.5 exposure on specific causes of death: exposure-response curves and effect modification among 53 million U.S. Medicare beneficiaries , 2020, Environmental Health.

[11]  Sun-young Kim,et al.  Air Pollution and Incidence of Lung Cancer by Histological Type in Korean Adults: A Korean National Health Insurance Service Health Examinee Cohort Study , 2020, International journal of environmental research and public health.

[12]  A. Whittemore,et al.  Association between ambient air pollution and breast cancer risk: The multiethnic cohort study , 2019, International journal of cancer.

[13]  C. Guda,et al.  Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability , 2020, Cancers.

[14]  G. Severi,et al.  Chronic long‐term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort , 2020, International journal of cancer.

[15]  Thomas C. Chen,et al.  Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study , 2020, JNCI cancer spectrum.

[16]  E. Rehfuess,et al.  Interventions to reduce ambient air pollution and their effects on health: An abridged Cochrane systematic review. , 2019, Environment international.

[17]  L. Morawska,et al.  The nexus between air pollution, green infrastructure and human health. , 2019, Environment international.

[18]  T. To,et al.  Associations between incident breast cancer and ambient concentrations of nitrogen dioxide from a national land use regression model in the Canadian National Breast Screening Study. , 2019, Environment international.

[19]  J. Christensen,et al.  Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort. , 2019, Environment international.

[20]  D. Wuebbles,et al.  Health Benefits of Air Pollution Reduction. , 2019, Annals of the American Thoracic Society.

[21]  B. Brunekreef,et al.  Surrounding green, air pollution, traffic noise exposure and non-accidental and cause-specific mortality. , 2019, Environment international.

[22]  S. Rajagopalan,et al.  Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice , 2019, Scientific Reports.

[23]  C. Flowers,et al.  Residential ambient benzene exposure in the United States and subsequent risk of hematologic malignancies , 2019, International journal of cancer.

[24]  Richard T Burnett,et al.  Fine particulate air pollution and human mortality: 25+ years of cohort studies. , 2019, Environmental research.

[25]  R. Burnett,et al.  Within-city Spatial Variations in Ambient Ultrafine Particle Concentrations and Incident Brain Tumors in Adults , 2019, Epidemiology.

[26]  Benjamin Bowe,et al.  Burden of Cause-Specific Mortality Associated With PM2.5 Air Pollution in the United States , 2019, JAMA network open.

[27]  Joshua P. Keller,et al.  Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort , 2019, Environmental health perspectives.

[28]  A. Keil,et al.  Airborne mammary carcinogens and breast cancer risk in the Sister Study. , 2019, Environment international.

[29]  Antonella Zanobetti,et al.  Long-term exposure to PM2.5 and ozone and hospital admissions of Medicare participants in the Southeast USA. , 2019, Environment international.

[30]  Joshua D. Higbee,et al.  Mortality Risk and Fine Particulate Air Pollution in a Large, Representative Cohort of U.S. Adults , 2019, Environmental health perspectives.

[31]  S. Horvath,et al.  Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation , 2019, Environment international.

[32]  J. Manjourides,et al.  Long-term ozone exposures and cause-specific mortality in a US Medicare cohort , 2019, Journal of Exposure Science & Environmental Epidemiology.

[33]  K. Rothman,et al.  Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose–Response Meta-Analysis , 2019, Environmental health perspectives.

[34]  B. Fisher,et al.  Breathing the same air? Socioeconomic disparities in PM2.5 exposure and the potential benefits from air filtration. , 2019, The Science of the total environment.

[35]  H. Khreis,et al.  Transforming Our Cities: Best Practices Towards Clean Air and Active Transportation , 2019, Current Environmental Health Reports.

[36]  C. Reche,et al.  Effectiveness of commercial face masks to reduce personal PM exposure. , 2019, The Science of the total environment.

[37]  N. Malats,et al.  Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study , 2019, International journal of cancer.

[38]  P. Kraft,et al.  Particulate Matter and Traffic-Related Exposures in Relation to Breast Cancer Survival , 2019, Cancer Epidemiology, Biomarkers & Prevention.

[39]  Virgil Pavlu,et al.  Long-term NO2 exposures and cause-specific mortality in American older adults , 2019, Environment international.

[40]  Young Kee Shin,et al.  Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview , 2018, Cellular Physiology and Biochemistry.

[41]  B. Brunekreef,et al.  Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE). , 2018, Environment international.

[42]  M. Tucker,et al.  Outdoor particulate matter (PM10) exposure and lung cancer risk in the EAGLE study , 2018, PloS one.

[43]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[44]  Chris C. Lim,et al.  Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter , 2018, Proceedings of the National Academy of Sciences.

[45]  T. To,et al.  Residential exposure to fine particulate matter air pollution and incident breast cancer in a cohort of Canadian women , 2018, Environmental Epidemiology.

[46]  P. Villeneuve,et al.  Occupational Exposure to Diesel and Gasoline Engine Exhausts and the Risk of Kidney Cancer in Canadian Men , 2018, Annals of work exposures and health.

[47]  B. Brunekreef,et al.  Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE) , 2018, International journal of cancer.

[48]  H. R. Anderson,et al.  Long-term Concentrations of Nitrogen Dioxide and Mortality , 2018, Epidemiology.

[49]  Kurt Straif,et al.  Identifying occupational carcinogens: an update from the IARC Monographs , 2018, Occupational and Environmental Medicine.

[50]  H. Solleiro-Villavicencio,et al.  Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases , 2018, Front. Cell. Neurosci..

[51]  Trang VoPham,et al.  Ambient PM2.5 air pollution exposure and hepatocellular carcinoma incidence in the United States , 2018, Cancer Causes & Control.

[52]  D. Pencheon,et al.  Local action on outdoor air pollution to improve public health , 2018, International Journal of Public Health.

[53]  M. Alves-Correia,et al.  Multiple Victims of Carbon Monoxide Poisoning in the Aftermath of a Wildfire: A Case Series. , 2018, Acta medica portuguesa.

[54]  R. Tamimi,et al.  Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses’ health study II , 2018, Environmental Health.

[55]  P. Bradshaw,et al.  Air Pollution and Breast Cancer: a Review , 2018, Current Epidemiology Reports.

[56]  Heather E. Danysh,et al.  Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring , 2018, International journal of environmental research and public health.

[57]  Lidia Morawska,et al.  Mobile phones as monitors of personal exposure to air pollution: Is this the future? , 2018, PloS one.

[58]  A. Puisieux,et al.  Cellular Pliancy and the Multistep Process of Tumorigenesis. , 2018, Cancer cell.

[59]  É. Lavigne,et al.  Associations between long-term PM2.5 and ozone exposure and mortality in the Canadian Census Health and Environment Cohort (CANCHEC), by spatial synoptic classification zone. , 2018, Environment international.

[60]  I. Annesi-Maesano.  The air of Europe: where are we going? , 2017, European Respiratory Review.

[61]  P. Kraft,et al.  Residential particulate matter and distance to roadways in relation to mammographic density: results from the Nurses’ Health Studies , 2017, Breast Cancer Research.

[62]  Peng Yin,et al.  Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men , 2017, Environmental health perspectives.

[63]  Michael Brauer,et al.  Associations between fine particulate matter and mortality in the 2001 Canadian Census Health and Environment Cohort , 2017, Environmental research.

[64]  Justin Manjourides,et al.  Long-Term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults , 2017, American journal of epidemiology.

[65]  Álvaro R. Osornio-Vargas,et al.  Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis. , 2017, Environmental pollution.

[66]  S. Günther,et al.  Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion , 2017, Epigenetics.

[67]  Gunn Marit Aasvang,et al.  Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE) , 2017, Neuro-oncology.

[68]  F. Lurmann,et al.  Particulate matter air pollution and liver cancer survival , 2017, International journal of cancer.

[69]  R. Burnett,et al.  Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II , 2017, Environmental health perspectives.

[70]  S. Soret,et al.  The association between ambient fine particulate matter and incident adenocarcinoma subtype of lung cancer , 2017, Environmental Health.

[71]  Eva Steliarova-Foucher,et al.  International incidence of childhood cancer, 2001–10: a population-based registry study , 2017, The Lancet. Oncology.

[72]  B. Sprague,et al.  Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium , 2017, Breast Cancer Research.

[73]  B. Brunekreef,et al.  Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project , 2017, Environmental research.

[74]  Division on Earth.  Using 21st Century Science to Improve Risk-Related Evaluations , 2017 .

[75]  Lin Xie,et al.  Maternal exposure to ambient air pollution and risk of early childhood cancers: A population-based study in Ontario, Canada. , 2017, Environment international.

[76]  Haidong Kan,et al.  Long-term exposure to ambient air pollution and mortality in a Chinese tuberculosis cohort. , 2017, The Science of the total environment.

[77]  B. Qian,et al.  PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells. , 2017, Biochimica et biophysica acta. General subjects.

[78]  Audrey de Nazelle,et al.  Comparison of air pollution exposures in active vs. passive travel modes in European cities: A quantitative review. , 2017, Environment international.

[79]  P. Pauwels,et al.  Deep sequencing of the TP53 gene reveals a potential risk allele for non–small cell lung cancer and supports the negative prognostic value of TP53 variants , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[80]  Z. Andersen,et al.  Long-term Exposure to Fine Particulate Matter and Breast Cancer Incidence in the Danish Nurse Cohort Study , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[81]  B. Brunekreef,et al.  Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts. , 2016, European urology focus.

[82]  I. Kloog,et al.  Association between ambient air pollution and proliferation of umbilical cord blood cells. , 2016, Environmental research.

[83]  W. Guan,et al.  Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action , 2016, The Lancet.

[84]  Mark Stevenson,et al.  City planning and population health: a global challenge , 2016, The Lancet.

[85]  F. Bull,et al.  Use of science to guide city planning policy and practice: how to achieve healthy and sustainable future cities , 2016, The Lancet.

[86]  Gunn Marit Aasvang,et al.  Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts , 2016, International journal of cancer.

[87]  J. Leem,et al.  Long-term residential exposure to air pollution and lung cancer in Korea , 2016 .

[88]  Samuel Soret,et al.  The Association between Ambient Fine Particulate Air Pollution and Lung Cancer Incidence: Results from the AHSMOG-2 Study , 2016, Environmental health perspectives.

[89]  F. Lurmann,et al.  Air pollution affects lung cancer survival , 2016, Thorax.

[90]  R. Martin,et al.  Long‐term exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study , 2016, International journal of cancer.

[91]  Z. Andersen,et al.  Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort. , 2016, Neurotoxicology.

[92]  Daniel Krewski,et al.  Long-Term Ozone Exposure and Mortality in a Large Prospective Study. , 2016, American journal of respiratory and critical care medicine.

[93]  P. Gosset,et al.  In vitro short-term exposure to air pollution PM2.5-0.3 induced cell cycle alterations and genetic instability in a human lung cell coculture model. , 2016, Environmental research.

[94]  T. Lam,et al.  Cancer Mortality Risks from Long-term Exposure to Ambient Fine Particle , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[95]  R. Chen,et al.  microRNA-802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure , 2016, Oncotarget.

[96]  R. Burnett,et al.  Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). , 2016, Environmental research.

[97]  O. Raaschou-Nielsen,et al.  Traffic‐related air pollution and risk for leukaemia of an adult population , 2016, International journal of cancer.

[98]  Chien-Jen Chen,et al.  Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV). , 2016, Journal of the National Cancer Institute.

[99]  O. Raaschou-Nielsen,et al.  Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark , 2016, Cancer Causes & Control.

[100]  Michael Brauer,et al.  Risk estimates of mortality attributed to low concentrations of ambient fine particulate matter in the Canadian community health survey cohort , 2016, Environmental Health.

[101]  B. Brunekreef,et al.  Particulate matter air pollution components and risk for lung cancer. , 2016, Environment international.

[102]  M. Egger,et al.  Childhood cancer and residential exposure to highways: a nationwide cohort study , 2015, European Journal of Epidemiology.

[103]  Michael Brauer,et al.  Ambient PM2.5, O3, and NO2 Exposures and Associations with Mortality over 16 Years of Follow-Up in the Canadian Census Health and Environment Cohort (CanCHEC) , 2015, Environmental health perspectives.

[104]  B. Ritz,et al.  In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA , 2015, Environmental health perspectives.

[105]  K. He,et al.  Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells , 2015, PloS one.

[106]  J. Lelieveld,et al.  The contribution of outdoor air pollution sources to premature mortality on a global scale , 2015, Nature.

[107]  P. Villeneuve,et al.  Exposure to ambient air pollution in Canada and the risk of adult leukemia. , 2015, The Science of the total environment.

[108]  Heather E. Danysh,et al.  Traffic‐related air pollution and the incidence of childhood central nervous system tumors: Texas, 2001–2009 , 2015, Pediatric blood & cancer.

[109]  Mingming Shao,et al.  Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells , 2015, Oncotarget.

[110]  R. Martin,et al.  Long-Term Trends Worldwide in Ambient NO2 Concentrations Inferred from Satellite Observations , 2015, Environmental health perspectives.

[111]  Teresa To,et al.  Long-term Exposure to Fine Particulate Matter Air Pollution and Mortality Among Canadian Women , 2015, Epidemiology.

[112]  J. Schwartz,et al.  Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study , 2015, Epigenetics.

[113]  D. J. Carlin,et al.  Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[114]  A. Cohen,et al.  Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis , 2015, Environmental health perspectives.

[115]  Ping Wang,et al.  Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer , 2015, EBioMedicine.

[116]  A. Tjønneland,et al.  Long-term exposure to air pollution and mammographic density in the Danish Diet, Cancer and Health cohort , 2015, Environmental Health.

[117]  N. Rothman,et al.  Household air pollution and cancers other than lung: a meta-analysis , 2015, Environmental Health.

[118]  C. Demetriou,et al.  Carcinogenicity of ambient air pollution: use of biomarkers, lessons learnt and future directions. , 2015, Journal of thoracic disease.

[119]  M. Vinceti,et al.  A Review and Meta-Analysis of Outdoor Air Pollution and Risk of Childhood Leukemia , 2015, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

[120]  H. Najmabadi,et al.  Evaluation of chromosomal aberrations caused by air pollutants in some taxi drivers from two polluted districts of urban Tehran and its comparison with drivers from rural areas of Lahijan: a pilot study , 2014, Journal of Environmental Health Science and Engineering.

[121]  A. Cohen,et al.  Interactions between cigarette smoking and fine particulate matter in the Risk of Lung Cancer Mortality in Cancer Prevention Study II. , 2014, American journal of epidemiology.

[122]  Keywan Riahi,et al.  Household Cooking with Solid Fuels Contributes to Ambient PM2.5 Air Pollution and the Burden of Disease , 2014, Environmental health perspectives.

[123]  Xiaoling Ma,et al.  No association between traffic density and risk of childhood leukemia: a meta-analysis. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[124]  Hongbing Shen,et al.  Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China. , 2014, Toxicology letters.

[125]  C. la Vecchia,et al.  Occupational exposures to polycyclic aromatic hydrocarbons and respiratory and urinary tract cancers: an updated systematic review and a meta-analysis to 2014 , 2014, Archives of Toxicology.

[126]  Paolo Vineis,et al.  Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis , 2014, Environmental health perspectives.

[127]  Molin Wang,et al.  Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort , 2014, Environmental health perspectives.

[128]  J. Schwartz,et al.  Effects of short‐term exposure to inhalable particulate matter on DNA methylation of tandem repeats , 2014, Environmental and molecular mutagenesis.

[129]  Arthur M. Wendel,et al.  Residential traffic exposure and childhood leukemia: a systematic review and meta-analysis. , 2014, American journal of preventive medicine.

[130]  Kurt Straif,et al.  The carcinogenicity of outdoor air pollution. , 2013, The Lancet Oncology.

[131]  B. Ritz,et al.  Prenatal exposure to traffic-related air pollution and risk of early childhood cancers. , 2013, American journal of epidemiology.

[132]  Kazuhiko Ito,et al.  National Particle Component Toxicity (NPACT) Initiative: integrated epidemiologic and toxicologic studies of the health effects of particulate matter components. , 2013, Research report.

[133]  M. Brauer,et al.  Long-term Residential Exposure to Air Pollution and Lung Cancer Risk , 2013, Epidemiology.

[134]  Daniel Krewski,et al.  Spatial analysis of air pollution and mortality in California. , 2013, American journal of respiratory and critical care medicine.

[135]  B. Brunekreef,et al.  Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). , 2013, The Lancet. Oncology.

[136]  Tjeerd van Staa,et al.  Mortality associations with long-term exposure to outdoor air pollution in a national English cohort. , 2013, American journal of respiratory and critical care medicine.

[137]  Jun Wu,et al.  Abstract 2531: Childhood cancer and traffic-related air pollution exposure in pregnancy and early life. , 2013 .

[138]  M. Stafoggia,et al.  Long-Term Exposure to Urban Air Pollution and Mortality in a Cohort of More than a Million Adults in Rome , 2013, Environmental health perspectives.

[139]  Andrew W. Correia,et al.  Effect of Air Pollution Control on Life Expectancy in the United States: An Analysis of 545 U.S. Counties for the Period from 2000 to 2007 , 2013, Epidemiology.

[140]  A. Wiczkowski,et al.  Oxidative damage and carcinogenesis , 2012, Contemporary oncology.

[141]  Joel Schwartz,et al.  Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009 , 2012, Environmental health perspectives.

[142]  D. Prada,et al.  Satellite 2 demethylation induced by 5-azacytidine is associated with missegregation of chromosomes 1 and 16 in human somatic cells. , 2012, Mutation research.

[143]  Kurt Straif,et al.  Preventable exposures associated with human cancers. , 2011, Journal of the National Cancer Institute.

[144]  C. Pope,et al.  Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. , 2011, American journal of respiratory and critical care medicine.

[145]  Michael Jerrett,et al.  Long-term exposure to air pollution and cardiorespiratory disease in the California teachers study cohort. , 2011, American journal of respiratory and critical care medicine.

[146]  T. Ohsaka,et al.  Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment , 2011, Gut.

[147]  Daniel Krewski,et al.  Lung Cancer and Cardiovascular Disease Mortality Associated with Ambient Air Pollution and Cigarette Smoke: Shape of the Exposure–Response Relationships , 2011, Environmental health perspectives.

[148]  Martin Hvidberg,et al.  Air pollution from traffic and cancer incidence: a Danish cohort study , 2011, Environmental health : a global access science source.

[149]  Jie Cao,et al.  Ambient Temperature and Mortality: An International Study in 13 Cities of East Asia , 2010, The Science of the total environment.

[150]  Kiyoshi Tanabe,et al.  An Association Between Long-Term Exposure to Ambient Air Pollution and Mortality From Lung Cancer and Respiratory Diseases in Japan , 2011, Journal of epidemiology.

[151]  Majid Ezzati,et al.  Fine-particulate air pollution and life expectancy in the United States. , 2009, The New England journal of medicine.

[152]  Z. Meng,et al.  Effect of sulfur dioxide on expression of proto‐oncogenes and tumor suppressor genes from rats , 2009, Environmental toxicology.

[153]  R. Burnett,et al.  Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality. , 2009, Research report.

[154]  Antonella Zanobetti,et al.  Rapid DNA methylation changes after exposure to traffic particles. , 2009, American journal of respiratory and critical care medicine.

[155]  Stanley T. Omaye,et al.  Air pollutants, oxidative stress and human health. , 2009, Mutation research.

[156]  J. Schwartz,et al.  Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation , 2008, Environmental health perspectives.

[157]  Paride Mantecca,et al.  Organic compounds in tire particle induce reactive oxygen species and heat-shock proteins in the human alveolar cell line A549. , 2008, Environment international.

[158]  Bert Brunekreef,et al.  Long-Term Effects of Traffic-Related Air Pollution on Mortality in a Dutch Cohort (NLCS-AIR Study) , 2007, Environmental health perspectives.

[159]  N. Malats,et al.  Air pollution and risk of urinary bladder cancer in a case-control study in Spain , 2007, Occupational and Environmental Medicine.

[160]  P. Gosset,et al.  Activation of different pathways of apoptosis by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture. , 2006, Toxicology.

[161]  J. Schwartz,et al.  Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. , 2006, American journal of respiratory and critical care medicine.

[162]  R. Burnett,et al.  Spatial Analysis of Air Pollution and Mortality in Los Angeles , 2005, Epidemiology.

[163]  V. Arlt.  3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. , 2005, Mutagenesis.

[164]  F Kauffmann,et al.  Twenty five year mortality and air pollution: results from the French PAARC survey , 2005, Occupational and Environmental Medicine.

[165]  L. Claxton,et al.  The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity. , 2004, Mutation research.

[166]  P. Kyyrönen,et al.  Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among finnish workers exposed to diesel or gasoline engine exhaust , 2004, International journal of cancer.

[167]  N. Malats,et al.  Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution , 2004, Occupational and Environmental Medicine.

[168]  P. Reynolds,et al.  Residential Exposure to Traffic in California and Childhood Cancer , 2004, Epidemiology.

[169]  F. Lipfert,et al.  Commentary on the HEI Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality , 2003, Journal of toxicology and environmental health. Part A.

[170]  Paul A. White,et al.  Air pollution induces heritable DNA mutations , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[171]  Susan J Clark,et al.  DNA methylation and gene silencing in cancer: which is the guilty party? , 2002, Oncogene.

[172]  R. Burnett,et al.  Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. , 2002, JAMA.

[173]  M. Brauer,et al.  Air pollution and retained particles in the lung. , 2001, Environmental health perspectives.

[174]  M. Ceppi,et al.  Analysis of 13 (32)P-DNA postlabeling studies on occupational cohorts exposed to air pollution. , 2001, American journal of epidemiology.

[175]  W. Mcdonnell,et al.  Relationships of mortality with the fine and coarse fractions of long-term ambient PM10 concentrations in nonsmokers , 2000, Journal of Exposure Analysis and Environmental Epidemiology.

[176]  J. Matschullat.  Arsenic in the geosphere--a review. , 2000, The Science of the total environment.

[177]  G. Casetta,et al.  White blood cell DNA adducts, smoking, and NAT2 and GSTM1 genotypes in bladder cancer: a case-control study. , 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[178]  F P Perera,et al.  A molecular epidemiological case-control study of lung cancer. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[179]  D. Dockery,et al.  Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. , 1995, American journal of respiratory and critical care medicine.

[180]  D. Dockery,et al.  An association between air pollution and mortality in six U.S. cities. , 1993, The New England journal of medicine.

[181]  H C Pitot,et al.  The molecular biology of carcinogenesis , 1993, Cancer.

[182]  B. Dunn,et al.  Carcinogen adducts as an indicator for the public health risks of consuming carcinogen-exposed fish and shellfish. , 1991, Environmental health perspectives.

[183]  P. Cerutti,et al.  Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[184]  W. Lowrance,et al.  Of Acceptable Risk: Science and the Determination of Safety , 1976 .

[185]  R. Doll,et al.  Smoking and Carcinoma of the Lung , 1950, Acta - Unio Internationalis Contra Cancrum.

[186]  Mark Payne,et al.  Health and Human Services , 2020, Congress and the Nation 2013-2016, Volume XIV: Politics and Policy in the 113th and 114th Congresses.

[187]  Mohammad Hosein Farzaei,et al.  Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2018, Lancet.

[188]  W J Fisk,et al.  Health benefits and costs of filtration interventions that reduce indoor exposure to PM2.5 during wildfires , 2017, Indoor air.

[189]  Luoping Zhang,et al.  Systematic Reviews and Meta- and Pooled Analyses Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis , 2015 .

[190]  Thomas J. Smith,et al.  Long-term ambient multipollutant exposures and mortality. , 2011, American journal of respiratory and critical care medicine.

[191]  Iarc Monographs,et al.  Household use of solid fuels and high-temperature frying. , 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

[192]  J. Stockman,et al.  Fine-Particulate Air Pollution and Life Expectancy in the United States , 2010 .

[193]  George D. Thurston,et al.  Outdoor Air Pollution: Sources, Atmospheric Transport, and Human Health Effects , 2008 .

[194]  Barry Halliwell,et al.  Oxidative stress and cancer: have we moved forward? , 2007, The Biochemical journal.

[195]  A. Baulig,et al.  Fine urban atmospheric particulate matter modulates inflammatory gene and protein expression in human bronchial epithelial cells. , 2007, Frontiers in bioscience : a journal and virtual library.

[196]  G. Thurston,et al.  Identifying and quantifying transported vs. local sources of New York City PM2.5 fine particulate matter air pollution , 2006 .

[197]  Hiroyuki Tsuda,et al.  WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , 2005 .

[198]  Daniel Krewski,et al.  Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air , 2000 .

[199]  M. Benarie.  Estimating human exposure to air pollutants. , 1982, WHO offset publication.

[200]  J. Higginson.  International Agency for Research on Cancer. , 1968, WHO chronicle.

[201]  S. Vardoulakis,et al.  Environmental Research and Public Health Air Quality Strategies on Public Health and Health Equity in Europe—a Systematic Review , 2022 .