Retraction: Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J. Cell. Sci. doi: 10.1242/102848

The journal is retracting ‘Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium’ by Ahmed H. K. El-Hashash, Gianluca Turcatel, Saaket Varma, Mohamed Berika, Denise Al Alam and David Warburton (2012). [ J. Cell Sci . 125, 4036-4048 (doi: 10.1242/102848)][1].

[1]  Y. Soini.  Claudins in lung diseases , 2011, Respiratory research.

[2]  H. Tokumitsu,et al.  Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium , 2011, Development.

[3]  S. Dahan,et al.  Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. , 2011, Gastroenterology.

[4]  D. Warburton,et al.  Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. , 2011, Developmental biology.

[5]  R. Hegde,et al.  The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells , 2010, Oncogene.

[6]  S. Muthuswamy,et al.  Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. , 2009, Current opinion in cell biology.

[7]  D. Guidolin,et al.  miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. , 2009, Developmental biology.

[8]  C. Doe,et al.  Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. , 2009, Developmental biology.

[9]  Chris Q. Doe,et al.  Spindle orientation during asymmetric cell division , 2009, Nature Cell Biology.

[10]  Christopher K. Glass,et al.  Tyrosine Dephosphorylation of H2AX Modulates Apoptosis and Survival Decisions , 2009, Nature.

[11]  M. Endo,et al.  Cdc42-mTOR Signaling Pathway Controls Hes5 and Pax6 Expression in Retinoic Acid-dependent Neural Differentiation* , 2009, Journal of Biological Chemistry.

[12]  I. Rebay,et al.  Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. , 2009, Developmental cell.

[13]  A. Hall,et al.  Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis , 2008, The Journal of cell biology.

[14]  Carien M Niessen,et al.  Tight junctions/adherens junctions: basic structure and function. , 2007, The Journal of investigative dermatology.

[15]  E. Mazzon,et al.  Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation , 2007, Respiratory research.

[16]  I. Rebay,et al.  The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. , 2007, Annual review of biochemistry.

[17]  R. Rao,et al.  Protein Phosphatases 2A and 1 Interact with Occludin and Negatively Regulate the Assembly of Tight Junctions in the CACO-2 Cell Monolayer* , 2007, Journal of Biological Chemistry.

[18]  P. Thibault,et al.  aPKC‐mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb , 2007, The EMBO journal.

[19]  H. Vankelecom,et al.  The notch signaling system is present in the postnatal pituitary: marked expression and regulatory activity in the newly discovered side population. , 2006, Molecular endocrinology.

[20]  U. Lendahl,et al.  High levels of Notch signaling down-regulate Numb and Numblike , 2006, The Journal of cell biology.

[21]  J. Sontag,et al.  Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation , 2006, Cellular and Molecular Life Sciences CMLS.

[22]  B. Margolis,et al.  Tight junctions and cell polarity. , 2006, Annual review of cell and developmental biology.

[23]  D. Siderovski,et al.  Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. , 2006, Molecular biology of the cell.

[24]  D. Warburton,et al.  Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. , 2006, Developmental biology.

[25]  D. Warburton,et al.  VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. , 2006, Developmental biology.

[26]  S. Kimber,et al.  PTHrP induces changes in cell cytoskeleton and E-cadherin and regulates Eph/Ephrin kinases and RhoGTPases in murine secondary trophoblast cells. , 2006, Developmental biology.

[27]  D. Warburton,et al.  A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. , 2005, Developmental biology.

[28]  S. Kimber,et al.  PTHrP promotes murine secondary trophoblast giant cell differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types. , 2005, Differentiation; research in biological diversity.

[29]  D. Warburton,et al.  In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[30]  Bernd Fritzsch,et al.  Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes , 2004, Development.

[31]  A. Püschel,et al.  The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity , 2004, Nature Neuroscience.

[32]  G. Dontu,et al.  Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells , 2004, Breast Cancer Research.

[33]  A. Hopkins,et al.  RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. , 2004, American journal of physiology. Cell physiology.

[34]  R. Klein,et al.  Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. , 2004, Developmental biology.

[35]  J. Beckmann,et al.  Six and Eya expression during human somitogenesis and MyoD gene family activation , 2004, Journal of Muscle Research & Cell Motility.

[36]  Takaaki Hirai,et al.  Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. , 2003, Journal of biochemistry.

[37]  D. Warburton,et al.  mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[38]  A. Suzuki,et al.  aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization , 2002, Journal of Cell Science.

[39]  C. White,et al.  Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex , 2002, The Journal of cell biology.

[40]  Susan E. Wert,et al.  Early restriction of peripheral and proximal cell lineages during formation of the lung , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Maas,et al.  Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. , 2002, Development.

[42]  Y. Nagashima,et al.  Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. , 2002, Journal of cell science.

[43]  J. Lipschutz,et al.  Exocytosis: The Many Masters of the Exocyst , 2002, Current Biology.

[44]  S. Ohno.  Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. , 2001, Current opinion in cell biology.

[45]  F. Huang,et al.  Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[46]  Y. Nagai,et al.  PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[47]  O. Farokhzad,et al.  Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms. , 2001, American journal of physiology. Cell physiology.

[48]  Shoichiro Tsukita,et al.  Multifunctional strands in tight junctions , 2001, Nature Reviews Molecular Cell Biology.

[49]  T. Ohnishi,et al.  Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures , 2001, The Journal of cell biology.

[50]  M. Prentki,et al.  Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. , 2001, Diabetes.

[51]  J. M. Mullin,et al.  The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha. , 2000, Experimental cell research.

[52]  D. Sacks,et al.  E-cadherin-mediated Cell-Cell Attachment Activates Cdc42* , 2000, The Journal of Biological Chemistry.

[53]  A. P. Soler,et al.  Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. , 2000, Journal of cell science.

[54]  L. Shoshani,et al.  Molecular physiology and pathophysiology of tight junctions. I. Biogenesis of tight junctions and epithelial polarity. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[55]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors. , 2000, The Biochemical journal.

[56]  Joe C. Adams,et al.  Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia , 1999, Nature Genetics.

[57]  B. Kachar,et al.  Redistribution and Phosphorylation of Occludin During Opening and Resealing of Tight Junctions in Cultured Epithelial Cells , 1999, The Journal of Membrane Biology.

[58]  R. Scheller,et al.  Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. , 1999, Trends in cell biology.

[59]  A. Newton,et al.  Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) , 1998, Current Biology.

[60]  S. Atkinson,et al.  Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. , 1998, American journal of physiology. Cell physiology.

[61]  M. Saitou,et al.  Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation , 1997, The Journal of cell biology.

[62]  R. O. Stuart,et al.  Regulated assembly of tight junctions by protein kinase C. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[63]  L. Lim,et al.  The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts , 1995, Molecular and cellular biology.

[64]  C. Limatola,et al.  Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids. , 1994, The Biochemical journal.

[65]  A. Newton,et al.  In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. , 1994, The Journal of biological chemistry.

[66]  A. Ponce,et al.  Role of calcium in tight junction formation between epithelial cells. , 1990, The American journal of physiology.