论文信息 - Performance of Large-Volume versus Small-Volume Holding Chambers with Chlorofluorocarbon-Albuterol and Hydrofluoroalkane-Albuterol Sulfate

Performance of Large-Volume versus Small-Volume Holding Chambers with Chlorofluorocarbon-Albuterol and Hydrofluoroalkane-Albuterol Sulfate

BACKGROUND:The recent development of non-chlorofluorocarbon propellant formulations for pressurized metered-dose inhalers prompts the need for the comparative evaluation of dose delivery by small- versus large-volume holding chambers (HCs). The performance of 2 representative largeand small-volume HCs has been investigated with chlorofluorocarbon-formulated albuterol (Ventolin) and hydrofluoroalkane-formulated albuterol sulfate (Airomir) with the objective of studying the influence of chamber capacity on so-called “fine-particle” dose and total dose. Three AeroChamber and a similar number of Volumatic HCs were tested with each formulation. METHODS: An 8-stage Andersen cascade impactor was used to determine mass-weighted size distributions of drug delivered at the mouthpiece of each HC. The mass of albuterol (Ventolin) or albuterol sulfate (Airomir) collected in the impactor was assayed by high performance liquid chromatography with ultraviolet detection in order to measure both fine-particle dose ( 95% of fine

J. L. Rau | M. Nagel | J. Mitchell

[1] N. Klinger,et al. Proventil HFA provides protection from exercise-induced bronchoconstriction comparable to proventil and ventolin. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[2] P. Barry,et al. In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices. , 1997, The European respiratory journal.

[3] J. Wildhaber,et al. Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. , 1996, The European respiratory journal.

[4] D. Tashkin,et al. Cumulative dose-response study of non-CFC propellant HFA 134a salbutamol sulfate metered-dose inhaler in patients with asthma. , 1996, Chest.

[5] M Lippmann,et al. Deposition, retention, and clearance of inhaled particles. , 1980, British journal of industrial medicine.

[6] F. Morén. Drug deposition of pressurized inhalation aerosols I. Influence of actuator tube design , 1978 .

[7] J. Wildhaber,et al. Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilator circuits: an in vitro study. , 1998, Chest.

[8] C. O’Callaghan,et al. The Optimum Size and Shape of Spacer Devices for Inhalational Therapy , 1995 .

[9] M. Dolovich,et al. Lung dose, distribution, and clinical response to therapeutic aerosols , 1993 .