The Anticancer Activity of Indazole Compounds: A Mini Review.

The incidence and mortality of cancer continue to grow since the current medical treatments often fail to produce a complete and durable tumor response, and ultimately give rise to therapy resistance and tumor relapse. Heterocycles with potential therapeutic values are of great pharmacological importance, and among them, indazole moiety is privileged struc-ture in medicinal chemistry. Indazole compounds possess potential anticancer activity, and the indazole-based agents Ax-itinib, Lonidamine and Pazopanib have already been applied for cancer therapy, demonstrating indazole compounds are useful templates for the development of novel anticancer agents. The aim of this review is to present the main aspects of exploring anticancer properties, such as the structural modifications, the structure-activity relationship and mechanisms of action, making an effort to highlight the importance and therapeutic potentials of the indazole compounds in the present anticancer agents.