Nuclear transport and cancer: from mechanism to intervention

[1]  U. Brinkmann,et al.  CSE1L/CAS: Its role in proliferation and apoptosis , 2004, Apoptosis.

[2]  Jiandong Chen,et al.  Nuclear exclusion of p53 in a subset of tumors requires MDM2 function , 2000, Oncogene.

[3]  Carlos L. Arteaga,et al.  PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization , 2002, Nature Medicine.

[4]  T. Hunter,et al.  Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. Biegel,et al.  Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  M. Fornerod,et al.  Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. , 1995, Oncogene.

[7]  Thomas Henkel,et al.  Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit , 1992, Cell.

[8]  C. Maki,et al.  The MDM2 RING-finger domain is required to promote p53 nuclear export , 2000, Nature Cell Biology.

[9]  Y. Nishizuka,et al.  Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P. Cohen,et al.  Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B* , 1999, The Journal of Biological Chemistry.

[11]  W. Sellers,et al.  Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[12]  W. Greene,et al.  I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. , 1992, Molecular biology of the cell.

[13]  B. Henderson,et al.  Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. , 2003, Experimental cell research.

[14]  M. Cleary,et al.  CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity , 1999, Molecular and Cellular Biology.

[15]  I. Mattaj,et al.  Nucleocytoplasmic transport: the soluble phase. , 1998, Annual review of biochemistry.

[16]  B. Gumbiner,et al.  Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin , 1998, Current Biology.

[17]  J. Qin,et al.  Parc A Cytoplasmic Anchor for p53 , 2003, Cell.

[18]  A. Sakurada,et al.  PTEN1 is frequently mutated in primary endometrial carcinomas , 1997, Nature Genetics.

[19]  B. Henderson.  Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover , 2000, Nature Cell Biology.

[20]  M. Goldberg,et al.  High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores , 1992, The Journal of cell biology.

[21]  R. Krumlauf.  Hox genes in vertebrate development , 1994, Cell.

[22]  Geert J. P. L. Kops,et al.  Direct control of the Forkhead transcription factor AFX by protein kinase B , 1999, Nature.

[23]  U. Scherf,et al.  The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Rayet,et al.  Aberrant rel/nfkb genes and activity in human cancer , 1999, Oncogene.

[25]  J. Vonesch,et al.  Negative cross‐talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells , 2000, The EMBO journal.

[26]  V. Rotter,et al.  Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis , 1990, Molecular and cellular biology.

[27]  Su-mi Han,et al.  Truncated Form of Importin α Identified in Breast Cancer Cell Inhibits Nuclear Import of p53* , 2000, The Journal of Biological Chemistry.

[28]  S Ichii,et al.  Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. , 1992, Human molecular genetics.

[29]  Pamela A. Silver,et al.  A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. , 2003, Cancer cell.

[30]  Mariann Bienz,et al.  Nuclear export of the APC tumour suppressor controls β‐catenin function in transcription , 2003, The EMBO journal.

[31]  I. Macara,et al.  Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX , 2001, Molecular and Cellular Biology.

[32]  S. R. Wente,et al.  The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. , 2000, Current opinion in cell biology.

[33]  C. Dargemont,et al.  Evidence for a role of CRM1 in signal-mediated nuclear protein export. , 1997, Science.

[34]  J. Bruce,et al.  Somatic mutations of PTEN in glioblastoma multiforme. , 1997, Cancer research.

[35]  N. Perkins.  The Rel/NF-κB family: friend and foe , 2000 .

[36]  Tomohiko Maehama,et al.  The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.

[37]  John Saunders,et al.  Friend and Foe , 1890, The Hospital.

[38]  M. Clarke,et al.  Cooperation of a Single Lysine Mutation and a C-terminal Domain in the Cytoplasmic Sequestration of the p53 Protein* , 1998, The Journal of Biological Chemistry.

[39]  M. Loda,et al.  Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN , 2000, Molecular and Cellular Biology.

[40]  L. Peso,et al.  Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt , 1999, Oncogene.

[41]  R. Mirimanoff,et al.  Clinical implications of the p53 tumor-suppressor gene. , 1994, The New England journal of medicine.

[42]  U. Kutay,et al.  The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus , 1997, The EMBO journal.

[43]  U. Scherf,et al.  Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. , 1996, Biochemistry.

[44]  W. Greene,et al.  Regulation of distinct biological activities of the NF-κB transcription factor complex by acetylation , 2003, Journal of Molecular Medicine.

[45]  DH Lam,et al.  NUP98 gene fusions in hematologic malignancies , 2001, Leukemia.

[46]  P. Cohen,et al.  Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion , 2002, The EMBO journal.

[47]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[48]  M. Yanagida,et al.  Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. , 1998, Experimental cell research.

[49]  Karsten Weis,et al.  Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor , 1997, Cell.

[50]  N. Kudo,et al.  Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[51]  A. Harris,et al.  Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer. , 1991, Oncogene.

[52]  Matthew W. Strobeck,et al.  Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1arrest associated with induction of p16ink4a and activation of RB , 2002, Oncogene.

[53]  D. Wiederschain,et al.  Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export , 2001, Molecular and Cellular Biology.

[54]  S. Horinouchi,et al.  A Role for Hsc70 in Regulating Nucleocytoplasmic Transport of a Temperature-sensitive p53 (p53Val-135)* , 2001, Journal of Biological Chemistry.

[55]  M. Polymeropoulos,et al.  The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. , 1996, Genome research.

[56]  P. Cohen,et al.  Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. , 2001, The Biochemical journal.

[57]  K. Shinomiya,et al.  Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells , 2002, Oncogene.

[58]  J. Slingerland,et al.  PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest , 2002, Nature Medicine.

[59]  F. Fagotto,et al.  The ins and outs of APC and β‐catenin nuclear transport , 2002 .

[60]  J. Barrett,et al.  Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[61]  D. Woods,et al.  C-Terminal Ubiquitination of p53 Contributes to Nuclear Export , 2001, Molecular and Cellular Biology.

[62]  B. Chait,et al.  Proteomic analysis of the mammalian nuclear pore complex , 2002, The Journal of cell biology.

[63]  N. Imamoto,et al.  beta-catenin can be transported into the nucleus in a Ran-unassisted manner. , 1999, Molecular biology of the cell.

[64]  J. Massagué,et al.  Breast cancer banishes p27 from nucleus , 2002, Nature Medicine.

[65]  Liang Zhu,et al.  Cell Cycle Arrest and Repression of Cyclin D1 Transcription by INI1/hSNF5 , 2002, Molecular and Cellular Biology.

[66]  G. Blobel,et al.  The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex , 1995, Cell.

[67]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[68]  G. Wahl,et al.  A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking , 1999, The EMBO journal.

[69]  M. Okada,et al.  Chromosome banding studies in 106 cases of chronic myelogenous leukemia , 1982, Japanese Journal of Human Genetics.

[70]  F. Bischoff,et al.  Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor , 1997, Cell.

[71]  P. Cohen,et al.  The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. , 2001, The Biochemical journal.

[72]  U. Moll,et al.  Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage , 1996, Molecular and cellular biology.

[73]  G. Kalpana,et al.  A masked NES in INI1/hSNF5 mediates hCRM1‐dependent nuclear export: implications for tumorigenesis , 2002, The EMBO journal.

[74]  Y. Nagashima,et al.  PTEN/MMAC1/TEP1 mutations in human primary renal‐cell carcinomas and renal carcinoma cell lines , 2001, International journal of cancer.

[75]  P. Polakis.  Wnt signaling and cancer. , 2000, Genes & development.

[76]  Bert Vogelstein,et al.  APC mutations occur early during colorectal tumorigenesis , 1992, Nature.

[77]  I. Pastan,et al.  Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells. , 1997, Biochemistry.

[78]  B. Gumbiner,et al.  Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins. , 2003, Experimental cell research.

[79]  Brian A. Hemmings,et al.  Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a) , 2001, Molecular and Cellular Biology.

[80]  M. Rout,et al.  The Nuclear Pore Complex as a Transport Machine* , 2001, The Journal of Biological Chemistry.

[81]  Raymond L. White,et al.  APC‐mediated downregulation of β‐catenin activity involves nuclear sequestration and nuclear export , 2000, EMBO reports.

[82]  Keisuke Toyama,et al.  The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9 , 1996, Nature Genetics.

[83]  Michael B. Yaffe,et al.  14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport , 2002, The Journal of cell biology.

[84]  U. Moll,et al.  Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[85]  Y. Xiong,et al.  A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation , 2001, Science.

[86]  Minoru Yoshida,et al.  CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals , 1997, Cell.

[87]  U. Brinkmann,et al.  CSE 1 L / CAS : Its role in proliferation and apoptosis , 2022 .

[88]  Minoru Yoshida,et al.  Nuclear Export of Human β-Catenin Can Occur Independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppressor* , 2001, The Journal of Biological Chemistry.

[89]  D. Dilworth,et al.  The dynamics of karyopherin-mediated nuclear transport. , 2001, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[90]  Alfonso Bellacosa,et al.  Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer , 2002, Nature Medicine.

[91]  M. Ohtsubo,et al.  Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene , 1990, Molecular and cellular biology.

[92]  M. Radermacher,et al.  Architecture of the Xenopus nuclear pore complex revealed by three- dimensional cryo-electron microscopy , 1993, The Journal of cell biology.

[93]  K. Hoang-Xuan,et al.  Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations. , 1999, Human molecular genetics.

[94]  K. Vousden,et al.  Regulation and function of the p53 tumor suppressor protein. , 2001, Current opinion in cell biology.

[95]  K. Tsai,et al.  An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 , 2000, Nature Cell Biology.

[96]  Ronald A. Milligan,et al.  Architecture and design of the nuclear pore complex , 1992, Cell.

[97]  B. Cullen,et al.  Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[98]  D. Forbes,et al.  Purification of the vertebrate nuclear pore complex by biochemical criteria. , 2000, Traffic.

[99]  I. Pastan,et al.  High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. , 2001, International journal of molecular medicine.

[100]  R. Kreienberg,et al.  Subcellular localization of accumulated p53 in ovarian cancer cells. , 1996, Gynecologic oncology.

[101]  S. Ruben,et al.  I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. , 1992, Genes & development.

[102]  A. Feinberg,et al.  Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia , 1996, Nature Genetics.

[103]  K. Guan,et al.  Negative Regulation of the Forkhead Transcription Factor FKHR by Akt* , 1999, The Journal of Biological Chemistry.

[104]  C. L. Schlamp,et al.  Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells. , 1997, Journal of the National Cancer Institute.

[105]  C. Feldherr,et al.  Signal-mediated nuclear transport in proliferating and growth-arrested BALB/c 3T3 cells , 1991, The Journal of cell biology.

[106]  U Aebi,et al.  The nuclear pore complex: from molecular architecture to functional dynamics. , 1999, Current opinion in cell biology.

[107]  U. Kutay,et al.  Transport between the cell nucleus and the cytoplasm. , 1999, Annual review of cell and developmental biology.

[108]  Yusuke Nakamura,et al.  Mutations of the APC adenomatous polyposis coli) gene , 1993, Human mutation.

[109]  Michael Karin,et al.  NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.

[110]  R. Medema,et al.  AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.

[111]  Olivier Delattre,et al.  Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer , 1998, Nature.

[112]  Rakesh Kumar,et al.  Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells , 2003, FEBS letters.

[113]  Minoru Yoshida,et al.  CRM1 is responsible for intracellular transport mediated by the nuclear export signal , 1997, Nature.

[114]  U. Scherf,et al.  The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS. , 1998, Biochemical and biophysical research communications.

[115]  G. Curigliano,et al.  Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis. , 1996, European journal of cancer.

[116]  Mariann Bienz,et al.  The APC tumour suppressor has a nuclear export function , 2000, Nature.

[117]  M. Rosbash,et al.  The NES–Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae , 1999, The EMBO journal.

[118]  W. Sellers,et al.  The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. , 2000, Biochimica et biophysica acta.

[119]  I. Pastan,et al.  Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[120]  O. Delattre,et al.  A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle , 2002, Oncogene.

[121]  Hans Clevers,et al.  Caught up in a Wnt storm: Wnt signaling in cancer. , 2003, Biochimica et biophysica acta.

[122]  横屋 史彦.  β-catenin can be transported into the nucleus in a Ran-unassisted manner , 1999 .

[123]  E. Newlands,et al.  Phase I trial of elactocin. , 1996, British Journal of Cancer.

[124]  A. Levine,et al.  Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[125]  U. Brinkmann,et al.  Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development. , 2001, Anticancer research.

[126]  D. Goldfarb,et al.  Evolutionary specialization of the nuclear targeting apparatus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[127]  Olivier Delattre,et al.  Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 , 2001, Nature Medicine.

[128]  A. Levine,et al.  Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. , 1992, Proceedings of the National Academy of Sciences of the United States of America.