Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro

[1]  M. Caroli,et al.  Aspirin Affects Tumor Angiogenesis and Sensitizes Human Glioblastoma Endothelial Cells to Temozolomide, Bevacizumab, and Sunitinib, Impairing Vascular Endothelial Growth Factor-Related Signaling. , 2018, World neurosurgery.

[2]  Chong Zhang,et al.  Synergistic antitumor activity of aspirin and erlotinib: Inhibition of p38 enhanced aspirin plus erlotinib-induced suppression of metastasis and promoted cancer cell apoptosis. , 2018, Oncology letters.

[3]  J. Saavedra,et al.  ATF3 reduces migration capacity by regulation of matrix metalloproteinases via NFκB and STAT3 inhibition in glioblastoma , 2017, Cell Death Discovery.

[4]  J. Saavedra,et al.  Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme , 2016, Cell Death and Disease.

[5]  G. FitzGerald,et al.  Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells , 2016, OncoTarget.

[6]  T. Das,et al.  Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug , 2016, BMC Cancer.

[7]  Y. Joo,et al.  Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis. , 2014, Oncology reports.

[8]  G. Shurin,et al.  Early growth response-2 signaling mediates immunomodulatory effects of human multipotential stromal cells. , 2014, Stem cells and development.

[9]  Kaiming Xu,et al.  COX-2 overexpression increases malignant potential of human glioma cells through Id1 , 2013, Oncotarget.

[10]  D. Son,et al.  Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells , 2013, Journal of Cancer.

[11]  J. Saavedra,et al.  Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI. , 2013, Nitric oxide : biology and chemistry.

[12]  J. Hung,et al.  Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells , 2013, Evidence-based complementary and alternative medicine : eCAM.

[13]  P. Rothwell,et al.  Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials , 2012, The Lancet.

[14]  Oliver P. T. Barrett,et al.  Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target , 2012, The Biochemical journal.

[15]  A. Papazoglou,et al.  Growth‐inhibitory and chemosensitizing effects of the glutathione‐S‐transferase‐π‐activated nitric oxide donor PABA/NO in malignant gliomas , 2012, International journal of cancer.

[16]  A. Papazoglou,et al.  JS-K, a Glutathione S-Transferase–Activated Nitric Oxide Donor With Antineoplastic Activity in Malignant Gliomas , 2012, Neurosurgery.

[17]  E. Oldfield,et al.  Differential effects of nitric oxide on blood-brain barrier integrity and cerebral blood flow in intracerebral C6 gliomas. , 2011, Neuro-Oncology.

[18]  G. Heusch,et al.  Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion , 2010, Basic Research in Cardiology.

[19]  M. A. Ajmone-Cat,et al.  Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions , 2010, Pharmaceuticals.

[20]  P. Bernardi,et al.  Signal transduction to the permeability transition pore , 2010, FEBS letters.

[21]  K. Kashfi,et al.  Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. , 2009, Biochemical pharmacology.

[22]  J. Saavedra,et al.  JS-K, an arylating nitric oxide (NO) donor, has synergistic anti-leukemic activity with cytarabine (ARA-C). , 2009, Leukemia research.

[23]  G. Molema,et al.  COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature. , 2009, Translational oncology.

[24]  I. Stratford,et al.  iNOS as a therapeutic target for treatment of human tumors. , 2008, Nitric oxide : biology and chemistry.

[25]  B. Cillero-Pastor,et al.  Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. , 2008, Arthritis and rheumatism.

[26]  M. Lai,et al.  Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. , 2008, World journal of gastroenterology.

[27]  J. Garthwaite.  Concepts of neural nitric oxide-mediated transmission , 2008, The European journal of neuroscience.

[28]  J. Streibig,et al.  An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments , 2007, Environmental and Ecological Statistics.

[29]  C. Trautwein,et al.  Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. , 2006, Cancer research.

[30]  S. Snyder,et al.  Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2 , 2005, Science.

[31]  Martin J. van den Bent,et al.  Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. , 2005, The New England journal of medicine.

[32]  A. Contestabile,et al.  Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation , 2004, Neurochemistry International.

[33]  P. Bernardi,et al.  Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-XL- and PKB/AKT-independent fashion , 2004, Cell Death and Differentiation.

[34]  S. Krauss,et al.  Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. , 2003, Arthritis and rheumatism.

[35]  J. García-Sancho,et al.  Calcium Influx through Receptor-operated Channel Induces Mitochondria-triggered Paraptotic Cell Death* 210 , 2003, The Journal of Biological Chemistry.

[36]  Yusuke Nakamura,et al.  EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK , 2003, Oncogene.

[37]  K. M. Davies,et al.  JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. , 2003, Molecular cancer therapeutics.

[38]  A. Scovassi,et al.  Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update , 2002, Apoptosis.

[39]  N. Maggiano,et al.  Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. , 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

[40]  R. Tallarida.  The interaction index: a measure of drug synergism , 2002, Pain.

[41]  J. Masferrer,et al.  Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. , 2002, Cancer research.

[42]  I. Roninson,et al.  If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. , 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[43]  K. M. Davies,et al.  The secondary amine/nitric oxide complex ion R(2)N[N(O)NO](-) as nucleophile and leaving group in S9N)Ar reactions. , 2001, The Journal of organic chemistry.

[44]  M. Duchen.  Mitochondria and calcium: from cell signalling to cell death , 2000, The Journal of physiology.

[45]  F. Lang,et al.  Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[46]  K. Seibert,et al.  Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. , 2000, Cancer research.

[47]  H. Hsieh,et al.  Nitric oxide regulates shear stress-induced early growth response-1. Expression via the extracellular signal-regulated kinase pathway in endothelial cells. , 1999, Circulation research.

[48]  M Crompton,et al.  The mitochondrial permeability transition pore and its role in cell death. , 1999, The Biochemical journal.

[49]  M. Currie,et al.  Nitric oxide activates cyclooxygenase enzymes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[50]  L. Ignarro.  Biosynthesis and metabolism of endothelium-derived nitric oxide. , 1990, Annual review of pharmacology and toxicology.