Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals.

[1]  Hironori Katoh,et al.  RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo , 2003, Nature.

[2]  S. Baksh,et al.  Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal , 2003, Cell.

[3]  Swathi Arur,et al.  Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. , 2003, Developmental cell.

[4]  A. Rosengarth,et al.  A calcium-driven conformational switch of the N-terminal and core domains of annexin A1. , 2003, Journal of molecular biology.

[5]  G. Laurent,et al.  Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36. , 2003, The American journal of pathology.

[6]  P. Williamson,et al.  Transbilayer phospholipid movement and the clearance of apoptotic cells. , 2002, Biochimica et biophysica acta.

[7]  A. Hall,et al.  Rho GTPases in cell biology , 2002, Nature.

[8]  John Savill,et al.  A blast from the past: clearance of apoptotic cells regulates immune responses , 2002, Nature Reviews Immunology.

[9]  M. Walport,et al.  Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex1 , 2002, The Journal of Immunology.

[10]  N. Brot,et al.  I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation , 2002, The Journal of experimental medicine.

[11]  Gerald R. Fink,et al.  Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex , 2002, Nature Cell Biology.

[12]  O. Witte,et al.  Lysophosphatidylcholine as a ligand for immunoregulation. , 2002, Biochemical pharmacology.

[13]  John Savill,et al.  Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment , 2002, Nature.

[14]  Keiko Miwa,et al.  Identification of a factor that links apoptotic cells to phagocytes , 2002, Nature.

[15]  N. Franc PHAGOCYTOSIS OF APOPTOTIC CELLS IN MAMMALS, CAENORHABDITIS ELEGANS AND DROSOPHILA MELANOGASTER: MOLECULAR MECHANISMS AND PHYSIOLOGICAL CONSEQUENCES , 2002 .

[16]  H. Su,et al.  Interaction of CED-6/GULP, an Adapter Protein Involved in Engulfment of Apoptotic Cells with CED-1 and CD91/Low Density Lipoprotein Receptor-related Protein (LRP)* , 2002, The Journal of Biological Chemistry.

[17]  S. Moss,et al.  Annexins: from structure to function. , 2002, Physiological reviews.

[18]  M. Barcinski,et al.  Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity , 2001, Current Biology.

[19]  A. Ridley,et al.  Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells , 2001, The Journal of cell biology.

[20]  O. Witte,et al.  Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4* , 2001, The Journal of Biological Chemistry.

[21]  M. Hengartner,et al.  CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration , 2001, Cell.

[22]  V. Fadok,et al.  Apoptotic cell removal , 2001, Current Biology.

[23]  H. Horvitz,et al.  The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. , 2001, Developmental cell.

[24]  M. Tsai,et al.  C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. , 2001, Developmental cell.

[25]  V. Fadok,et al.  Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. , 2001, The Journal of clinical investigation.

[26]  V. Fadok,et al.  C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells , 2001, The Journal of experimental medicine.

[27]  V. Fadok,et al.  The phosphatidylserine receptor: a crucial molecular switch? , 2001, Nature Reviews Molecular Cell Biology.

[28]  O. Witte,et al.  Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A , 2001, Science.

[29]  R. Schnabel,et al.  Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans , 2001, Nature.

[30]  H. Horvitz,et al.  Phagocytosis promotes programmed cell death in C. elegans , 2001, Nature.

[31]  P. Williamson,et al.  Phosphatidylserine, a death knell , 2001, Cell Death and Differentiation.

[32]  V. Fadok,et al.  If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer , 2001, Cell Death and Differentiation.

[33]  R. Scott,et al.  Phagocytosis and clearance of apoptotic cells is mediated by MER , 2001, Nature.

[34]  A. Rosengarth,et al.  Folding energetics of ligand binding proteins II. Cooperative binding of Ca2+ to annexin I. , 2001, Journal of molecular biology.

[35]  V. Fadok,et al.  Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts* , 2001, The Journal of Biological Chemistry.

[36]  Zheng Zhou,et al.  CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans , 2001, Cell.

[37]  W. Wood,et al.  Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos. , 2000, Development.

[38]  Matthew L. Albert,et al.  αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells , 2000, Nature Cell Biology.

[39]  W. Cho,et al.  Mechanism of annexin I-mediated membrane aggregation. , 2000, Biochemistry.

[40]  P. Taylor,et al.  A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo , 2000, The Journal of experimental medicine.

[41]  J. Scholes,et al.  Differences between the clearance of apoptotic cells by professional and non-professional phagocytes , 2000, Current Biology.

[42]  C. Lagenaur,et al.  Role of CD47 as a marker of self on red blood cells. , 2000, Science.

[43]  Yannick Hamon,et al.  ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. , 2000, Nature Cell Biology.

[44]  V. Fadok,et al.  A receptor for phosphatidylserine-specific clearance of apoptotic cells , 2000, Nature.

[45]  V. Gerke,et al.  A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. , 2000, Molecular cell.

[46]  L. Shultz,et al.  Defective macrophage recruitment and clearance of apoptotic cells in the uterus of osteopetrotic mutant mice lacking macrophage colony-stimulating factor (M-CSF). , 2000, Journal of submicroscopic cytology and pathology.

[47]  H. Horvitz,et al.  CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans , 2000, Nature Cell Biology.

[48]  C. Gregory CD14-dependent clearance of apoptotic cells: relevance to the immune system. , 2000, Current opinion in immunology.

[49]  H. Castro-Faria-Neto,et al.  Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages , 2000, Nature.

[50]  M. Hengartner,et al.  Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6 , 1999, Current Biology.

[51]  R. Klemke,et al.  Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells , 1999, The Journal of cell biology.

[52]  B. Krammer,et al.  Cutting edge: differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities. , 1999, Journal of immunology.

[53]  A. Devitt,et al.  Macrophage recognition of ICAM-3 on apoptotic leukocytes. , 1999, Journal of immunology.

[54]  V. Fadok,et al.  CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3). , 1998, Journal of immunology.

[55]  M. L. Beau,et al.  A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[56]  E. Rodriguez-Boulan,et al.  Morphogenesis of the Retinal Pigment Epithelium: Toward Understanding Retinal Degenerative Diseases a , 1998, Annals of the New York Academy of Sciences.

[57]  V. Fadok,et al.  The role of phosphatidylserine in recognition of apoptotic cells by phagocytes , 1998, Cell Death and Differentiation.

[58]  H. Horvitz,et al.  The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters , 1998, Cell.

[59]  M. Hengartner,et al.  Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans , 1998, Cell.

[60]  H. Horvitz,et al.  C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 , 1998, Nature.

[61]  V. Fadok,et al.  Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.

[62]  R. Voll,et al.  Immunosuppressive effects of apoptotic cells , 1997, Nature.

[63]  R. Lang,et al.  Macrophages induce apoptosis in normal cells in vivo. , 1997, Development.

[64]  H. Hanafusa,et al.  Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases* , 1996, The Journal of Biological Chemistry.

[65]  P. Guyre,et al.  Evidence for specific annexin I-binding proteins on human monocytes. , 1996, The Biochemical journal.

[66]  M. Yamamoto,et al.  Vitamin D‐binding protein (group‐specific component) is the sole serum protein required for macrophage activation after treatment of peritoneal cells with lysophosphatidylcholine , 1993, Immunology and cell biology.

[67]  D. Steinberg,et al.  Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. , 1993, The Journal of clinical investigation.

[68]  V. Fadok,et al.  Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. , 1992, Journal of immunology.

[69]  S. Parthasarathy,et al.  Analysis of the monocyte chemotactic response to lysophosphatidylcholine: role of lysophospholipase C. , 1991, Biochimica et biophysica acta.

[70]  K. Kragballe,et al.  Lysophosphatidylcholine: a chemoattractant to human T lymphocytes , 2004, Archives of Dermatological Research.

[71]  V. Fadok,et al.  Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. , 2002, The Journal of clinical investigation.

[72]  M. Lagarde,et al.  Characterization of plasma unsaturated lysophosphatidylcholines in human and rat. , 2000, The Biochemical journal.

[73]  M. Hengartner Programmed cell death in the nematode C. elegans. , 1999, Recent progress in hormone research.

[74]  M. Mochizuki,et al.  Serum proteins neutralize the toxic effect of lysophosphatidyl choline. , 1982, Current eye research.