PCBs and the precautionary principle

Polychlorinated biphenyls (PCBs) are chlorinated organic compounds that were first synthesised in the laboratory in 1881. By 1899 a pathological condition named chloracne had been identified, a painful disfiguring skin disease that affected people employed in the chlorinated organic industry. Mass production of PCBs for commercial use started in 1929. Thirty-seven years elapsed before PCBs became a major public issue, recognised as environmental pollutants, and a danger to animals and humans. Large-scale production worldwide, and in particular in some eastern European countries, continued until the mid-1980s. PCBs are the first obvious example of a substance that was not intentionally spread into the environment, but nevertheless became widespread and bioaccumulated to high concentrations.

[1]  V. Fidler,et al.  Neurological condition in 42-month-old children in relation to pre- and postnatal exposure to polychlorinated biphenyls and dioxins. , 1998, Early Human Development.

[2]  J. Jacobson,et al.  Effects of exposure to PCBs and related compounds on growth and activity in children. , 1990, Neurotoxicology and teratology.

[3]  S. Schantz,et al.  Neurochemical and Behavioral Sequelae of Exposure to Dioxins and PCBs , 1994 .

[4]  A. Bernard,et al.  Food contamination by PCBs and dioxins , 1999, Nature.

[5]  Abraham Brouwer,et al.  Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants , 1994, Pediatric Research.

[6]  C. Lanting Effects of perinatal PCB and dioxin exposure and early feeding mode on child development , 1999 .

[7]  D. Stalling,et al.  Are polychlorinated biphenyl residues adequately described by Aroclor mixture equivalents? Isomer-specific principal components analysis of such residues in fish and turtles , 1987 .

[8]  C. Koopman‐Esseboom,et al.  Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins. , 1995, Early human development.

[9]  J. Jacobson,et al.  Intellectual impairment in children exposed to polychlorinated biphenyls in utero. , 1996, The New England journal of medicine.

[10]  F. Muskiet,et al.  Polychlorinated Biphenyls in Adipose Tissue, Liver, and Brain from Nine Stillborns of Varying Gestational Ages , 1998, Pediatric Research.

[11]  Barry G. Oliver,et al.  Trophodynamic analysis of polychlorinated biphenyl congeners and other chlorinated hydrocarbons in the Lake Ontario ecosystem , 1988 .

[12]  J. Koppe,et al.  6. PCBs and the precautionary principle , 2000 .

[13]  R. Aulerich,et al.  Feeding Great Lakes fish to mink: effects on mink and accumulation and elimination of PCBS by mink. , 1983, Journal of toxicology and environmental health.

[14]  H. B. Mathews,et al.  Effect of chlorination on the distribution and excretion of polychlorinated biphenyls. , 1975, Drug metabolism and disposition: the biological fate of chemicals.

[15]  Y. Masuda The Yusho Rice Oil Poisoning Incident , 1994 .

[16]  D. Cibula,et al.  Cord blood levels of potentially neurotoxic pollutants (polychlorinated biphenyls, lead and cadmium) in the areas of Prague (Czech Republic) and Katowice (Poland). Comparison with reference values in The Netherlands. The Czech/Polish/Dutch/German Research Team. , 1994, Central European journal of public health.

[17]  C. Koopman‐Esseboom,et al.  Effects of perinatal exposure to PCBs and dioxins on early human development , 1995 .

[18]  G. J. Mellenbergh,et al.  Prenatal Exposure to Anticonvulsants and Psychosexual Development , 1999, Archives of sexual behavior.