The induction of prostatic hypertrophy in the dog with androstanediol.

The effects of androstanediol and estradiol on prostatic growth were investigated in castrate dogs. Estrogens along resulted in no significant change in prostatic weight, whereas androstanediol produced growth comparable to that in uncastrated controls. Androstanediol plus estradiol resulted in an even more striking increase in prostate growth. Approximately half the animals receiving androstanediol alone and all of those receiving androstanediol plus estradiol fulfill the weight and histological criteria for prostatic hypertrophy in the dog. Since both these steroid hormones are presumed to be normal secretory products of the testis, it is possible that they are involved in the pathogenesis of prostatic hypertrophy in the dog.

[1]  P. Siiteri,et al.  Androgen metabolism in the hypertrophic prostate , 1975 .

[2]  Ronald J. Moore,et al.  The Effect of Androgenic Hormones on the Reduced Nicotinamide Adenine Dinucleotide Phosphate: Δ4-3-Ketosteroid 5α-Oxidoreductase of Rat Ventral Prostate* , 1973 .

[3]  M. Jenner,et al.  Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome. , 1972, The Journal of clinical investigation.

[4]  C. Mackenzie,et al.  The signs and results of treatment of prostatic disease in dogs , 1971, Veterinary Record.

[5]  J. Wilson,et al.  Dihydrotestosterone in prostatic hypertrophy. II. The formation and content of dihydrotestosterone in the hypertrophic canine prostate and the effect of dihydrotestosterone on prostate growth in the dog. , 1970, The Journal of clinical investigation.

[6]  J. Wilson,et al.  Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man. , 1970, The Journal of clinical investigation.

[7]  O. Berg.  Parenchymatous hypertrophy of the canine prostate gland. , 1958, Acta endocrinologica.

[8]  O. Berg.  The normal prostate gland of the dog. , 1958, Acta endocrinologica.

[9]  W. Scott.  THE PHYSIOLOGY OF THE PROSTATE GLAND , 1945, Bulletin of the Johns Hopkins Hospital.

[10]  C. Schlotthauer.  Observations on the Prostate Gland of the Dog , 1932 .

[11]  J. Wilson,et al.  The intranuclear metabolism of testosterone in the accessory organs of reproduction. , 1970, Recent progress in hormone research.

[12]  P. Ofner.  Effects and metabolism of hormones in normal and neoplastic prostate tissue. , 1968, Vitamins and hormones.

[13]  J. O'Shea.  Studies on the canine prostate gland. I. Factors influencing its size and weight. , 1962, Journal of comparative pathology.

[14]  S. Zuckerman,et al.  The ætiology of benign enlargement of the prostate in the dog , 1937 .