The nature of tremor circuits in parkinsonian and essential tremor

See Arkadir et al. (doi:10.1093/brain/awu285) for a scientific commentary on this article. The mechanisms underlying tremor generation remain unclear. Cagnan et al. use deep brain stimulation of the thalamus or subthalamic nucleus at/near a patient's own tremor frequency to investigate the networks responsible for parkinsonian and essential tremor. The results reveal differences in the circuitry underlying these two tremor types.

[1]  Christian Hauptmann,et al.  Coordinated reset has sustained aftereffects in Parkinsonian monkeys , 2012, Annals of neurology.

[2]  Antonio Daniele,et al.  Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation , 2012, The Lancet Neurology.

[3]  Peter A. Tass,et al.  Long-term anti-kindling effects of desynchronizing brain stimulation: a theoretical study , 2005, Biological Cybernetics.

[4]  M. Hallett,et al.  Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? , 2012, Brain : a journal of neurology.

[5]  J. B. Gao,et al.  Analysis of amplitude and frequency variations of essential and Parkinsonian tremors , 2004, Medical and Biological Engineering and Computing.

[6]  D Curran-Everett,et al.  Multiple comparisons: philosophies and illustrations. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[7]  P. Brown,et al.  Tremor Suppression by Rhythmic Transcranial Current Stimulation , 2013, Current Biology.

[8]  Suzanne N Haber,et al.  Dopamine Replacement Therapy Does Not Restore the Full Spectrum of Normal Pallidal Activity in the 1-Methyl-4-Phenyl-1,2,3,6-Tetra-Hydropyridine Primate Model of Parkinsonism , 2006, The Journal of Neuroscience.

[9]  L. Oliver.  Surgery in Parkinson's Disease , 1955, Postgraduate medical journal.

[10]  G. Deuschl,et al.  The Pathophysiology of Essential Tremor and Parkinson’s Tremor , 2013, Current Neurology and Neuroscience Reports.

[11]  E. Vaadia,et al.  Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates , 1998, Trends in Neurosciences.

[12]  H. Kwan,et al.  Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. , 1994, Brain : a journal of neurology.

[13]  P. Thompson,et al.  Assessing tremor severity. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[14]  Joseph Jankovic,et al.  Comprar Parkinson's Disease and Movement Disorders, 6ª Ed. | Joseph Jankovic | 9781608311767 | Lippincott Williams & Wilkins , 2015 .

[15]  L. Tremblay,et al.  Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism , 1991, Brain Research.

[16]  R. Llinás.  Rebound excitation as the physiological basis for tremor: a biophysical study of the oscillatory pro , 1984 .

[17]  M. Hallett.  Overview of Human Tremor Physiology , 2008, Movement disorders : official journal of the Movement Disorder Society.

[18]  A. Morel,et al.  Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients , 2000, Neuroscience.

[19]  S. Groiss,et al.  Characterisation of tremor‐associated local field potentials in the subthalamic nucleus in Parkinson’s disease , 2009, The European journal of neuroscience.

[20]  R. Llinás,et al.  Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect , 2005, Trends in Neurosciences.

[21]  J. Penney,et al.  The functional anatomy of basal ganglia disorders , 1989, Trends in Neurosciences.

[22]  H. Freund,et al.  The cerebral oscillatory network of parkinsonian resting tremor. , 2003, Brain : a journal of neurology.

[23]  R. Llinás,et al.  Central motor loop oscillations in parkinsonian resting tremor revealed magnetoencephalography , 1996, Neurology.

[24]  R. Llinás.  The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. , 1988, Science.

[25]  G. Percheron,et al.  The primate motor thalamus , 1996, Brain Research Reviews.

[26]  M. Butz,et al.  A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease. , 2013, Brain : a journal of neurology.

[27]  W. Weiner.  Parkinson’s Disease and Movement Disorders , 2000, Current Clinical Practice.

[28]  R. Kristeva-Feige,et al.  Tremor-correlated cortical activity detected by electroencephalography , 2000, Clinical Neurophysiology.

[29]  A. Benabid,et al.  Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus , 1991, The Lancet.

[30]  L. Findley,et al.  Movement Disorders: Tremor , 1984, Palgrave Macmillan UK.

[31]  H. Kwan,et al.  Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor , 1995, Movement disorders : official journal of the Movement Disorder Society.

[32]  L. Oliver.  Surgery in Parkinson's disease; division of lateral pyramidal tract for tremor; report on 48 operations. , 1949, Lancet.

[33]  Germán Mato,et al.  Synchrony in Excitatory Neural Networks , 1995, Neural Computation.

[34]  P. Strick,et al.  The cerebellum communicates with the basal ganglia , 2005, Nature Neuroscience.

[35]  J. Vitek,et al.  Stimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons , 2003, The Journal of Neuroscience.

[36]  G. S. Russo,et al.  Subthalamic Nucleus Stimulation Modulates Thalamic Neuronal Activity , 2008, The Journal of Neuroscience.

[37]  John-Stuart Brittain,et al.  The many roads to tremor , 2013, Experimental Neurology.

[38]  W. Oyen,et al.  Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor , 2011, Annals of neurology.

[39]  A. E. Lang,et al.  Identification and characterization of neurons with tremor-frequency activity in human globus pallidus , 1997, Experimental Brain Research.

[40]  C. Gray,et al.  Dynamics of tremor-related oscillations in the human globus pallidus: a single case study. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[41]  P. Brown,et al.  Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation , 2013, Brain : a journal of neurology.

[42]  Andreea C. Bostan,et al.  The basal ganglia communicate with the cerebellum , 2010, Proceedings of the National Academy of Sciences.

[43]  K. Mewes,et al.  The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics. , 2001, Brain : a journal of neurology.

[44]  Bard Ermentrout,et al.  Type I Membranes, Phase Resetting Curves, and Synchrony , 1996, Neural Computation.

[45]  A L Benabid,et al.  Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation , 1998, Movement disorders : official journal of the Movement Disorder Society.

[46]  J. Matsumoto,et al.  Time-frequency analysis of tremors. , 1998, Brain : a journal of neurology.

[47]  G Bard Ermentrout,et al.  Phase-response curves and synchronized neural networks , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[48]  Charles J. Wilson,et al.  Activity Patterns in a Model for the Subthalamopallidal Network of the Basal Ganglia , 2002, The Journal of Neuroscience.

[49]  F. Lenz,et al.  Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits. , 2005, Journal of neurophysiology.