Adverse effects of antihistamines.

PreviewAntihistamines are in widespread use in clinical medicine, and their potential for side effects raises therapeutic concerns. What effects might the drugs have in children? In adults? What is the mechanism of action of the antihistamines? What factors define whether or not adverse effects will occur? Drs Schuller and Turkewitz address these and other questions in the following review.

[1]  J. Kemp,et al.  Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. , 1985, Annals of allergy.

[2]  R. N. Brogden,et al.  Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. , 1984, Drugs.

[3]  T. Betts,et al.  Effects of two antihistamine drugs on actual driving performance. , 1984, British medical journal.

[4]  F. Simons,et al.  H1 receptor antagonists: clinical pharmacology and use in allergic disease. , 1983, Pediatric clinics of North America.

[5]  D. Schuller.  Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children. , 1983, The Journal of allergy and clinical immunology.

[6]  D. Schuller.  235 The spectrum of antihistamines adversely affecting pulmonary function in asthmatic children , 1983 .

[7]  K. Simons,et al.  The pharmacokinetics and antihistaminic effects of brompheniramine. , 1982, The Journal of allergy and clinical immunology.

[8]  S. C. Hurley,et al.  Possible interactions of antihistamines and antibiotics with oral contraceptive effectiveness. , 1982, Fertility and sterility.

[9]  F. Simons,et al.  Pharmacokinetics and efficacy of chlorpheniramine in children. , 1982, The Journal of allergy and clinical immunology.

[10]  K. Leighton.  Paranoid psychosis after abuse of Actifed. , 1982, British medical journal.

[11]  J. Leysen,et al.  In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole. , 1982, Molecular pharmacology.

[12]  B. Stone,et al.  Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine. , 1982, British journal of clinical pharmacology.

[13]  R. Hook,et al.  Pharmacokinetics and biotransformation studies of terfenadine in man. , 1982, Arzneimittel-Forschung.

[14]  J. Triginer,et al.  THE I ANTIGEN AS AN IMMUNE COMPLEX RECEPTOR IN A CASE OF HAEMOLYTIC ANAEMIA INDUCED BY AN ANTIHISTAMINIC AGENT , 1981, British journal of haematology.

[15]  A. Levinson,et al.  Hypersensitivity reactions to ethylenediamine in aminophylline. , 1981, The American review of respiratory disease.

[16]  D. Weiner,et al.  Bioavailability of terfenadine in man. , 1981, Biopharmaceutics & drug disposition.

[17]  V. Popa.  Effect of an H1 blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma. , 1980, Chest.

[18]  M. Church,et al.  INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS , 1980, British journal of pharmacology.

[19]  Neil Massound.  Hypersensitivity to Vistaril in a child with asthma. , 1978 .

[20]  R. Evans,et al.  Further studies on the mechanism of human histamine-induced asthma: the effect of an aerosolized H1 receptor antagonist (diphenhydramine). , 1977, The Journal of allergy and clinical immunology.

[21]  B. Prenner.  Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride. , 1977, American journal of diseases of children.

[22]  V. Popa.  Bronchodilating activity of an H1 blocker, chlorpheniramine. , 1977, The Journal of allergy and clinical immunology.

[23]  P. Marriott.  Mandies are not dandy: another adverse drug interaction with methaqualone. , 1976, Comprehensive psychiatry.

[24]  B. Lavenstein,et al.  Acute Dystonia: An Unusual Reaction to Diphenhydramine , 1976 .

[25]  Favis Gr.  Letter: Facial dyskinesia related to antihistamine? , 1976 .

[26]  A. Maniatis,et al.  CHLORPHENIRAMINE-INDUCED BONE-MARROW SUPPRESSION , 1976, The Lancet.

[27]  H. Turndorf,et al.  Physostigmine reversal of antihistamine-induced excitement and depression. , 1975, Anesthesiology.

[28]  J. Bosma,et al.  Oral facial dyskinesia accociated with prolonged use of antihistaminic decongestants. , 1975, The New England journal of medicine.

[29]  I. Saxén.  CLEFT PALATE AND MATERNAL DIPHENHYDRAMINE INTAKE , 1974 .

[30]  Hyde Js,et al.  Theophylline and chlorpheniramine in childhood asthma. Dose requirements for children 6 to 12 years (therapeutic orphans) and young adults 13 to 18 years of age receiving cromolyn sodium prophylaxis. , 1974 .

[31]  D. Roman.  Schizophrenia-like Psychosis Following ‘Mandrax’ Overdose , 1972, British Journal of Psychiatry.

[32]  Karlin Jm.  The use of antihistamines in asthma. , 1972 .

[33]  Meisner Lf,et al.  Chemically-induced chromosome changes in human cells in vitro. , 1972 .

[34]  K. Fuxe,et al.  Effect of some antiparkinsonian drugs on catecholamine neurons , 1970, The Journal of pharmacy and pharmacology.

[35]  P. Gott.  Cyclizine Toxicity — Intentional Drug Abuse of a Proprietary Antihistamine , 1968 .

[36]  R. Markello,et al.  Circulatory and Respiratory Effects of Hydroxyzine in Volunteers and Geriatric Patients , 1968, Anesthesia and analgesia.

[37]  S. Nigro.  Toxic psychosis due to diphenhydramine hydrochloride. , 1968, JAMA.

[38]  J. Howell,et al.  Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. , 1966, American journal of obstetrics and gynecology.

[39]  G. King,et al.  PYRIBENZAMINE ACTIVATION OF THE ELECTROENCEPHALOGRAM. , 1965, Electroencephalography and clinical neurophysiology.

[40]  L. Lasagna,et al.  Effect of cyproheptadine on asthmatic children. Study of appetite, weight gain, and linear growth. , 1962, JAMA.

[41]  Crews Sj.  Toxic effects on the eye and visual apparatus resulting from the systemic absorption of recently introduced chemical agents. , 1962 .

[42]  J. Wyngaarden,et al.  THE TOXIC EFFECTS OF ANTI-HISTAMINIC DRUGS , 1951 .

[43]  J. Crumbley.  Anemia following use of antihistaminic drugs. , 1950, Journal of the American Medical Association.

[44]  H. S. Martland,et al.  Agranulocytosis after antihistaminic therapy; report of a case following the prolonged use of tripelennamine (pyribenzamine) hydrochloride. , 1950, Journal of the American Medical Association.

[45]  W. Peterson,et al.  Sensitization to antistine. , 1950, The Journal of investigative dermatology.

[46]  T. Aaron,et al.  Thephorin; an experimental and clinical evaluation in allergic states. , 1948, The Journal of allergy.

[47]  B. Sachs.  The toxicity of benadryl; report of a case and review of the literature. , 1948, Annals of internal medicine.

[48]  T. Aaron,et al.  Neohetramine; an experimental and clinical evaluation in allergic states. , 1948, The Journal of allergy.

[49]  J. Seabury,et al.  Spirometric evaluation of benadryl in asthma. , 1947, The Journal of allergy.

[50]  M. C. Borman.  Danger with benadryl of self medication and large dosage. , 1947, Journal of the American Medical Association.