Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231
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A. Aceto | A. Simi | S. Thellung | T. Florio | C. Russo | F. Raggi | D. Paludi | A. Corsaro | V. Villa | K. Chiovitti | Federica Raggi
[1] David R. Brown,et al. Resistance of cell lines to prion toxicity aided by phospho‐ERK expression , 2008, Journal of neurochemistry.
[2] G. Forloni,et al. The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection , 2008, PloS one.
[3] J. Bussink,et al. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. , 2008, The Lancet. Oncology.
[4] S. Mok,et al. Evaluation of drugs for treatment of prion infections of the central nervous system. , 2008, The Journal of general virology.
[5] Wei Liu,et al. A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia , 2008, Brain, Behavior, and Immunity.
[6] A. Aceto,et al. Intracellular accumulation of a mild‐denatured monomer of the human PrP fragment 90–231, as possible mechanism of its neurotoxic effects , 2007, Journal of neurochemistry.
[7] H. Kretzschmar,et al. Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants , 2007, Journal of neurochemistry.
[8] A. Aceto,et al. ERK1/2 and p38 MAP kinases control prion protein fragment 90–231‐induced astrocyte proliferation and microglia activation , 2007, Glia.
[9] I. Zerr,et al. Therapeutic approaches for prion disorders , 2007, Expert review of anti-infective therapy.
[10] J. Grosclaude,et al. In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers , 2007, PLoS pathogens.
[11] A. Aguzzi,et al. Insights into prion strains and neurotoxicity , 2007, Nature Reviews Molecular Cell Biology.
[12] N. Bhat,et al. p38α MAP Kinase Mediates Hypoxia-Induced Motor Neuron Cell Death: A Potential Target of Minocycline’s Neuroprotective Action , 2007, Neurochemical Research.
[13] David R. Brown,et al. Modelling neurodegeneration in prion disease – applications for drug development , 2007, Expert opinion on drug discovery.
[14] A. Aceto,et al. Amino‐Terminally Truncated Prion Protein PrP90‐231 Induces Microglial Activation in Vitro , 2007, Annals of the New York Academy of Sciences.
[15] E. Langella,et al. Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and α helix 2 human prion protein fragments , 2006, Proteins.
[16] A. Aceto,et al. Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231. , 2006, Annals of the New York Academy of Sciences.
[17] J. Collinge,et al. A systematic review of prion therapeutics in experimental models. , 2006, Brain : a journal of neurology.
[18] A. Aguzzi. Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis , 2006, Journal of neurochemistry.
[19] A. Aceto,et al. Conformation Dependent Pro-Apoptotic Activity of the Recombinant Human Prion Protein Fragment 90-231 , 2006, International journal of immunopathology and pharmacology.
[20] P. Peters,et al. Emerging pharmacotherapies for Creutzfeldt-Jakob disease. , 2006, Archives of neurology.
[21] J. Steeves,et al. Minocycline as a Neuroprotective Agent , 2005, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
[22] M. Duddy,et al. Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease. , 2005, The Journal of infection.
[23] C. Power,et al. For Personal Use. Only Reproduce with Permission from Elsevier Ltd Minocycline and Neurological Diseases Minocycline in Animal Models the Promise of Minocycline in Neurology , 2022 .
[24] Ming-tao Li,et al. Minocycline prevents glutamate‐induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways , 2004, Journal of neurochemistry.
[25] A. Sobel,et al. Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1‐7 neuronal cells , 2004, FEBS letters.
[26] P. Caplazi,et al. Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use , 2004, Journal of Clinical Pathology.
[27] D. Hess,et al. Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria* , 2004, Journal of Biological Chemistry.
[28] M. Salmona,et al. Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity* , 2004, Journal of Biological Chemistry.
[29] D. Hess,et al. Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection , 2004, Experimental Neurology.
[30] E. Irle,et al. Efficacy of flupirtine on cognitive function in patients with CJD , 2004, Neurology.
[31] M. E. Eichler,et al. Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[32] Tatsuo Yamada,et al. Results of Quinacrine Administration to Patients with Creutzfeldt-Jakob Disease , 2004, Dementia and Geriatric Cognitive Disorders.
[33] G. Damonte,et al. Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation , 2003, Annals of the New York Academy of Sciences.
[34] Carla Perrone-Capano,et al. Chronic activation of ERK and neurodegenerative diseases , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.
[35] J. Castilla,et al. Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein , 2003, The EMBO journal.
[36] G. Forloni,et al. Prion Diseases: Time for a Therapy ? , 2003 .
[37] G. Damonte,et al. Contribution of two conserved glycine residues to fibrillogenesis of the 106–126 prion protein fragment. Evidence that a soluble variant of the 106–126 peptide is neurotoxic , 2003, Journal of neurochemistry.
[38] G. Forloni,et al. Tetracyclines affect prion infectivity , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[39] G. Damonte,et al. Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein , 2002, Neurochemistry International.
[40] G. Damonte,et al. p38 MAP Kinase Mediates the Cell Death Induced by PrP106–126 in the SH-SY5Y Neuroblastoma Cells , 2002, Neurobiology of Disease.
[41] T. Cotter,et al. Prion Protein Fragment PrP-(106–126) Induces Apoptosis via Mitochondrial Disruption in Human Neuronal SH-SY5Y Cells* , 2001, The Journal of Biological Chemistry.
[42] S. Prusiner,et al. Shattuck lecture--neurodegenerative diseases and prions. , 2001, The New England journal of medicine.
[43] B. Fiebich,et al. Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia , 2001, The Journal of Neuroscience.
[44] Y. Kawaoka,et al. Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice , 2000, Nature Medicine.
[45] G. Forloni,et al. Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro. , 2000, Journal of molecular biology.
[46] G. Forloni,et al. Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106–126 , 2000, International Journal of Developmental Neuroscience.
[47] S. Hersch,et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease , 2000, Nature Medicine.
[48] M. Comalada,et al. The Differential Time-course of Extracellular-regulated Kinase Activity Correlates with the Macrophage Response toward Proliferation or Activation* , 2000, The Journal of Biological Chemistry.
[49] O. Khorkova,et al. α2-macroglobulin associates with β-amyloid peptide and prevents fibril formation , 1998 .
[50] J Collinge,et al. Human prion diseases and bovine spongiform encephalopathy (BSE). , 1997, Human molecular genetics.
[51] Michael E. Greenberg,et al. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.
[52] C. Marshall,et al. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.
[53] R J Fletterick,et al. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[54] A. Aguzzi,et al. Approaches to therapy of prion diseases. , 2005, Annual review of medicine.
[55] J. Collinge. Prion diseases of humans and animals: their causes and molecular basis. , 2001, Annual review of neuroscience.
[56] O. Khorkova,et al. Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[57] E. Nånberg,et al. Differentiation and survival influences of growth factors in human neuroblastoma. , 1995, European journal of cancer.