Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets
暂无分享,去创建一个
L. Staudt | J. Briones | A. López-Guillermo | L. Colomo | E. Campo | A. Salar | E. González-Barca | S. Mercadal | J. Sancho | L. Escoda | A. Valera | P. Jares | K. Akashi | N. López-Bigas | C. Rubio-Perez | A. Carrió | G. Castellano | G. Clot | D. Costa | A. Enjuanes | A. Navarro | C. Royo | I. Salaverria | D. Tamborero | G. R. Ordóñez | K. Karube | K. Ohshima | K. Ohshima | R. Schmitz | J. Rovira | B. González-Farré | L. Colomo | M. Alcoceba | F. Nadeu | K. Miyawaki | A. Mozos | H. Miyoshi | I. Dlouhy | A. Vaghefi | A. Carrió | K. Kato | J. Rovira | D. Martín-García | Alexandra Valera | Anna Carrió | B. González-Farré
[1] C. Popp,et al. Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis , 2019, Analytical cellular pathology.
[2] M. Katoh,et al. Precision medicine for human cancers with Notch signaling dysregulation (Review) , 2019, International journal of molecular medicine.
[3] W. Wilson,et al. The landscape of new drugs in lymphoma , 2017, Nature Reviews Clinical Oncology.
[4] C. Mamot,et al. Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort , 2017, Journal of Hematology & Oncology.
[5] Christopher A. Miller,et al. Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma. , 2017, Blood.
[6] Shaoping Ling,et al. Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors , 2016, Oncotarget.
[7] L. Staudt,et al. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma , 2016, Proceedings of the National Academy of Sciences.
[8] L. Pasqualucci,et al. Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma , 2016, Leukemia.
[9] C. Ruiz,et al. Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis , 2016, Leukemia.
[10] C. Copie-Bergman,et al. Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study , 2016, Clinical Cancer Research.
[11] M. Kersten,et al. Precision medicine in diffuse large B-cell lymphoma: hitting the target , 2015, Haematologica.
[12] Michael T. Zimmermann,et al. Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma , 2015, Blood Cancer Journal.
[13] A. Valencia,et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia , 2015, Nature.
[14] R. Verhaak,et al. Seek and destroy: relating cancer drivers to therapies. , 2015, Cancer cell.
[15] Michael P. Schroeder,et al. In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities. , 2015, Cancer cell.
[16] W. Klapper,et al. Characterization of genomic imbalances in diffuse large B‐cell lymphoma by detailed SNP‐chip analysis , 2015, International journal of cancer.
[17] Ryan D. Morin,et al. An RCOR1 loss-associated gene expression signature identifies a prognostically significant DLBCL subgroup. , 2015, Blood.
[18] S. Friend,et al. Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors. , 2015, Cancer discovery.
[19] E. Giné,et al. Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours , 2014, The Journal of pathology.
[20] A. Intlekofer,et al. Precision therapy for lymphoma—current state and future directions , 2014, Nature Reviews Clinical Oncology.
[21] Bruce D Cheson,et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[22] Kai Fu,et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. , 2014, Blood.
[23] F. Jardin,et al. Targetable activating mutations are very frequent in GCB and ABC diffuse large B‐cell lymphoma , 2014, Genes, chromosomes & cancer.
[24] M. Calaminici,et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma , 2013, Nature Genetics.
[25] Manel Juan,et al. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma , 2013, Proceedings of the National Academy of Sciences.
[26] David Tamborero,et al. OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes , 2013, Bioinform..
[27] Steven J. M. Jones,et al. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. , 2013, Blood.
[28] F. Jardin,et al. The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B‐cell lymphoma , 2013, Genes, chromosomes & cancer.
[29] G. Lenz,et al. PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma , 2013, Proceedings of the National Academy of Sciences.
[30] T. Haferlach,et al. STAT3 mutations are highly specific for large granular lymphocytic leukemia , 2013, Leukemia.
[31] Steven J. M. Jones,et al. Analysis of FOXO1 mutations in diffuse large B-cell lymphoma. , 2013, Blood.
[32] David Dunson,et al. Genetic heterogeneity of diffuse large B-cell lymphoma , 2013, Proceedings of the National Academy of Sciences.
[33] R. Spang,et al. SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients , 2012, Oncotarget.
[34] R. Spang,et al. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing , 2012, Nature Genetics.
[35] Dereje D. Jima,et al. The genetic landscape of mutations in Burkitt lymphoma , 2012, Nature Genetics.
[36] W. Choi,et al. Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. , 2012, Blood.
[37] Steven J. M. Jones,et al. Recurrent targets of aberrant somatic hypermutation in lymphoma , 2012, Oncotarget.
[38] Stefano Monti,et al. Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. , 2012, Cancer cell.
[39] K. Cibulskis,et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer , 2012, Nature Genetics.
[40] K. Elenitoba-Johnson,et al. Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma , 2012, The Journal of experimental medicine.
[41] S. Pileri,et al. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development , 2012, The Journal of experimental medicine.
[42] K. Hoang-Xuan,et al. Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas , 2012, Clinical Cancer Research.
[43] Ryan D. Morin,et al. BCL2 mutations in diffuse large B-cell lymphoma , 2012, Leukemia.
[44] F. Lang,et al. Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways , 2012, PloS one.
[45] Paul K. Brindle,et al. Is histone acetylation the most important physiological function for CBP and p300? , 2012, Aging.
[46] Eric S. Lander,et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing , 2012, Proceedings of the National Academy of Sciences.
[47] Govind Bhagat,et al. Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. , 2011, Cancer cell.
[48] Steven J. M. Jones,et al. Frequent mutation of histone modifying genes in non-Hodgkin lymphoma , 2011, Nature.
[49] Raul Rabadan,et al. Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma , 2011, Nature Genetics.
[50] Juliane C. Dohm,et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia , 2011, Nature.
[51] C. Sander,et al. Predicting the functional impact of protein mutations: application to cancer genomics , 2011, Nucleic acids research.
[52] J. Sprent,et al. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes , 2011, Nature Immunology.
[53] A. Gonzalez-Perez,et al. Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. , 2011, American journal of human genetics.
[54] Kenneth H. Buetow,et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia , 2011, Nature.
[55] B. Beutler,et al. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow , 2011, Nature Immunology.
[56] Joseph M. Connors,et al. Oncogenically active MYD88 mutations in human lymphoma , 2011, Nature.
[57] F. Lang,et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase , 2011, Journal of Cell Science.
[58] Raul Rabadan,et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma , 2010, Nature.
[59] Govind Bhagat,et al. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. , 2010, Cancer cell.
[60] W. Chan,et al. Genomic lesions associated with a different clinical outcome in diffuse large B‐Cell lymphoma treated with R‐CHOP‐21 , 2010, British journal of haematology.
[61] T. Molina,et al. Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study. , 2010, Blood.
[62] Jana Marie Schwarz,et al. MutationTaster evaluates disease-causing potential of sequence alterations , 2010, Nature Methods.
[63] P. Bork,et al. A method and server for predicting damaging missense mutations , 2010, Nature Methods.
[64] J. Soulier,et al. Mutation in TET2 in myeloid cancers. , 2009, The New England journal of medicine.
[65] A. Mottok,et al. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities. , 2009, Blood.
[66] H. Tagawa,et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. , 2009, Blood.
[67] Leyla Isik,et al. Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. , 2009, Cancer research.
[68] K. Owzar,et al. Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[69] L. Staudt,et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways , 2008, Proceedings of the National Academy of Sciences.
[70] L. Staudt,et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma. , 2008, Blood.
[71] T. Golub,et al. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas , 2008, Oncogene.
[72] G. Cattoretti,et al. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. , 2007, Blood.
[73] A. Look,et al. Mechanisms of transcription factor deregulation in lymphoid cell transformation , 2007, Oncogene.
[74] B. Coiffier. Rituximab therapy in malignant lymphoma , 2007, Oncogene.
[75] M. Bhasin,et al. Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc , 2006, Molecular and Cellular Biology.
[76] J. Aster,et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. , 2006, Genes & development.
[77] Stefano Monti,et al. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma , 2006, The Journal of experimental medicine.
[78] L. Staudt,et al. Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. , 2005, Blood.
[79] H. Tagawa,et al. Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. , 2005, Blood.
[80] Katia Basso,et al. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. , 2003, Blood.
[81] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[82] Meland,et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. , 2002, The New England journal of medicine.
[83] D. Hossfeld. E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues , 2002 .
[84] Gouri Nanjangud,et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas , 2001, Nature.
[85] Ash A. Alizadeh,et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.
[86] E. Campo,et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. , 1998, Blood.
[87] Steven A. Roberts,et al. Mutational heterogeneity in cancer and the search for new cancer genes , 2014 .
[88] Ryan D. Morin,et al. Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma. , 2012, Blood.
[89] S. Henikoff,et al. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm , 2009, Nature Protocols.
[90] L. Staudt,et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. , 2004, Blood.
[91] Emili Montserrat,et al. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. , 2003, Blood.
[92] E. Campo,et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. , 1998, Blood.