[Detection of hepatitis delta virus (HDV) markers in HBV carriers].

To investigate the prevalence and clinical features of hepatitis delta virus (HDV) superinfection in hepatitis B virus (HBV) carriers, antibody to hepatitis delta antigen (anti-HD) was determined in the sera of 328 HBV carriers in Japan. 1) Of the 328 HBV carriers, six (1.8%) were seropositive for anti-HD by enzyme linked immunosorbent assay. IgM-antibody to hepatitis delta antigen was detected in 2/6 patients with a high anti-HDV titer. None of the patients was positive for hepatitis dealt antigen. 2) HBV carriers with chronic liver disease had a greater frequency of seropositivity of anti-HD than asymptomatic HBV carriers. These data indicate that HDV superinfection may be an etiologic agent of chronic liver disease in HBV carriers.

[1]  E. Takezaki,et al.  A Long-Term Follow-Up of Five Patients with Hepatitis Delta Virus in Japan , 1991, The Journal of international medical research.

[2]  B. Portmann,et al.  Significance of IgM anti‐hepatitis D virus (HDV) in chronic HDV infection , 1991, Journal of medical virology.

[3]  G. Fattovich,et al.  Hepatitis C virus infection in chronic hepatitis B virus carriers. , 1991, The Journal of infectious diseases.

[4]  F. Imazeki,et al.  Heterogeneity and evolution rates of delta virus RNA sequences , 1990, Journal of virology.

[5]  H. Ichimura,et al.  Hepatitis δ virus infection in different time periods in Japan , 1990 .

[6]  M. Morris,et al.  The serology of delta hepatitis and the detection of IgM anti-HD by EIA using serum derived delta antigen. , 1989, Journal of virological methods.

[7]  T. Kurimura,et al.  Influence of hepatitis delta virus superinfection on the clearance of hepatitis B virus (HBV) markers in HBV carriers in Japan , 1988, Journal of medical virology.

[8]  T. Kurimura,et al.  Prevalence of antibody to delta antigen among HBV carriers in Japan , 1987, Journal of medical virology.

[9]  I. Gust,et al.  Detection of IgM Antibodies to Delta Antigen After Coinfection and Superinfection With the Delta Virus , 1986, Journal of medical virology.

[10]  M. Rizzetto,et al.  Diagnostic and prognostic significance of the IgM antibody to the hepatitis delta virus. , 1986, JAMA.

[11]  O. Yokosuka,et al.  Delta infection in Japan: Immunohistological and immuno‐electron microscopic study of delta antigen in liver tissue , 1986 .

[12]  D. Vergani,et al.  INFLUENCE OF DELTA INFECTION ON SEVERITY OF HEPATITIS B , 1982, The Lancet.

[13]  R. Purcell,et al.  EPIDEMIOLOGY OF HBV-ASSOCIATED DELTA AGENT: GEOGRAPHICAL DISTRIBUTION OF ANTI-DELTA AND PREVALENCE IN POLYTRANSFUSED HBsAg CARRIERS , 1980, The Lancet.

[14]  R. Purcell,et al.  Transmission of the hepatitis B virus-associated delta antigen to chimpanzees. , 1980, The Journal of infectious diseases.

[15]  R. Purcell,et al.  INCIDENCE AND SIGNIFICANCE OF ANTIBODIES TO DELTA ANTIGEN IN HEPATITIS B VIRUS INFECTION , 1979, The Lancet.