论文信息 - 4‐Picolyl Chloride Hydrochloride

4‐Picolyl Chloride Hydrochloride

[1822-51-1] C6H7Cl2N (MW 164.04) InChI = 1S/C6H6ClN.ClH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H InChIKey = ZDHKVKPZQKYREU-UHFFFAOYSA-N (protection of alcohols,1, 2 phenols,3 thiols,3, 4 and carboxylic acids5) Alternate Name: 4-(chloromethyl)pyridine hydrochloride. Physical Data: mp 160–163 °C. Solubility: sol H2O, EtOH; insol CH2Cl2, acetone. Form Supplied in: white or off-white crystalline solid; available from several commercial sources. Handling, Storage, and Precautions: the free base is reported to be unstable,1 and should be generated shortly before use.

P. Ham

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[3] H. Kunz,et al. The 2‐(2‐Pyridyl)ethoxycarbonyl‐(Pyoc) Residue—An Acid‐ and Base‐Stable, Hydrophilic Protecting Group for the Amino Function in Peptide Synthesis , 1983 .

[4] D. Veber,et al. Isonicotinyloxycarbonyl, a novel amino protecting group for peptide synthesis. , 1977, The Journal of organic chemistry.

[5] H. Kessler,et al. 2-(2-pyridyl-)ethyl esters A new carboxyl protecting group in peptide synthesis , 1984 .

[6] D. Stevenson,et al. Protection of thiol and phenolic hydroxy-groups as their 4-picolyl ethers, cleaved by electrolytic reduction , 1972 .