Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms.

[1]  I. Weissman,et al.  Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? , 2002, Oncogene.

[2]  Soyoung Lee,et al.  A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy , 2002, Cell.

[3]  J. Hendry,et al.  Role of damage-sensing/processing genes in the radiation response of haemopoietic in vitro colony-forming cells , 2002, International journal of radiation biology.

[4]  E. Hellström-Lindberg,et al.  The pharmacodynamic effect of busulfan in the P39 myeloid cell line in vitro , 2001, Leukemia.

[5]  F. Zindy,et al.  Differential effects of p19Arf and p16Ink4a loss on senescence of murine bone marrow-derived preB cells and macrophages , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D. Fisher,et al.  Key targets for the execution of radiation-induced tumor cell apoptosis: the role of p53 and caspases. , 2001, International journal of radiation oncology, biology, physics.

[7]  O. Pradier,et al.  In vitro response of human dermal fibroblasts to X-irradiation: relationship between radiation-induced clonogenic cell death, chromosome aberrations and markers of proliferative senescence or differentiation , 2001, International journal of radiation biology.

[8]  E. Medrano,et al.  Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes , 2000, Experimental Gerontology.

[9]  B. Dontje,et al.  Distinct functional properties of highly purified hematopoietic stem cells from mouse strains differing in stem cell numbers. , 2000, Blood.

[10]  A. Silva,et al.  Involvement of p53 and interleukin 3 in the up-regulation of CD95 (APO-1/Fas) by X-ray irradiation , 2000, Oncogene.

[11]  J. H. Meerwaldt,et al.  A new four-color flow cytometric assay to detect apoptosis in lymphocyte subsets of cultured peripheral blood cells. , 2000, Cytometry.

[12]  Z. Darżynkiewicz,et al.  Analysis of apoptotic cells by flow and laser scanning cytometry. , 2000, Methods in enzymology.

[13]  J. Hendry,et al.  Effect of bcl-2 deficiency on the radiation response of clonogenic cells in small and large intestine, bone marrow and testis. , 2000, International journal of radiation biology.

[14]  C. Print,et al.  Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[15]  S. Grant,et al.  Follicular dendritic cells protect malignant B cells from apoptosis induced by anti-Fas and antineoplastic agents. , 1999, Journal of immunology.

[16]  P. Buehler,et al.  Permanent cell cycle arrest in asynchronously proliferating normal human fibroblasts treated with doxorubicin or etoposide but not camptothecin. , 1999, Biochemical pharmacology.

[17]  S. Goud,et al.  Effects of sublethal radiation on bone marrow cells: induction of apoptosis and inhibition of antibody formation. , 1999, Toxicology.

[18]  S H Kaufmann,et al.  Mammalian caspases: structure, activation, substrates, and functions during apoptosis. , 1999, Annual review of biochemistry.

[19]  Y. Fujiwara,et al.  ZK1, a novel Krüppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. , 1998, Biochemical and biophysical research communications.

[20]  I. Weissman,et al.  Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation , 1998 .

[21]  G. Adami,et al.  Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts , 1998, Oncogene.

[22]  D. Harrison,et al.  Hematopoietic precursor cell exhaustion is a cause of proliferative defect in primitive hematopoietic stem cells (PHSC) after chemotherapy. , 1997, Experimental hematology.

[23]  V. Diehl,et al.  Apoptosis and proliferation (PCNA labelling) in CML—a comparative immunohistological study on bone marrow biopsies following interferon and busulfan therapy , 1997, The Journal of pathology.

[24]  P. Nicotera,et al.  Radiation induced apoptosis. , 1996, Mutation research.

[25]  G. Santos.  Preparative Regimens: Chemotherapy versus Chemoradiotherapy , 1995 .

[26]  J Sullivan,et al.  Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. , 1995, International journal of radiation oncology, biology, physics.

[27]  D. Goodhead,et al.  Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. , 1995, International journal of radiation biology.

[28]  G. Majno,et al.  Apoptosis, oncosis, and necrosis. An overview of cell death. , 1995, The American journal of pathology.

[29]  I. Weissman,et al.  The biology of hematopoietic stem cells. , 1995, Annual review of cell and developmental biology.

[30]  M. Newton,et al.  Behavior of Feline Hematopoietic Stem Cells Years After Busulfan Exposure , 1993 .

[31]  J. Down,et al.  Transient and permanent engraftment potential of murine hematopoietic stem cell subsets: differential effects of host conditioning with gamma radiation and cytotoxic drugs. , 1993, Experimental hematology.

[32]  J. M. Lee,et al.  p53 mutations increase resistance to ionizing radiation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[33]  S. Nishikawa,et al.  In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. , 1992, Blood.

[34]  J. Down,et al.  Murine haemopoietic stem cells with long-term engraftment and marrow repopulating ability are more resistant to gamma-radiation than are spleen colony forming cells. , 1992, International journal of radiation biology.

[35]  Der,et al.  An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. , 1989, Blood.

[36]  A. Marshak‐Rothstein,et al.  The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice. , 1987, Journal of immunology.

[37]  R. Storb,et al.  Allogeneic Bone‐Marrow Transplantation , 1983, Immunological reviews.

[38]  D. Harrison,et al.  Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure , 1982, The Journal of experimental medicine.